Clinical evidence dossier
Insulin therapy
Glucose iAUC (OGTT)
Evidence signal
Authoritative evidence signal
strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 3
- Supporting studies available for review
- 3
- Randomized trials
- 3
- Reported effects
- 9
Clinical conclusion
Insulin therapy shows a moderate positive evidence signal for improving Glucose iAUC (OGTT) across the studied comparisons.
The conclusion and evidence-signal classification are distinct authoritative fields and are reproduced as published.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Mean difference
-21.01 to 18.58 %
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 0
- Magnitude-eligible effects
- 2
Consistency
Authoritative consistency classification
mostly_consistent
- Positive
- 2
- No effect
- 0
- Mixed
- 0
- Negative
- 1
Population and applicability
Structured population data were available for 3 of 3 supporting studies. Diabetes type was heterogeneous: 2 studies with type 2 diabetes, 1 studies with type 1 diabetes. 2 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Participants using hybrid closed-loop insulin therapy.
- Elderly patients aged 65 and older with type 2 diabetes.
- Patients requiring insulin therapy for diabetes management.
- Adults diagnosed with type 2 diabetes
- Patients currently on premixed insulin therapy
Limitations
- 1 of 2 studies with duration data have follow-up of 12 weeks or less.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.