Clinical evidence dossier
Melatonin
HbA1c
Evidence signal
Authoritative evidence signal
strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 3
- Supporting studies available for review
- 3
- Randomized trials
- 3
- Reported effects
- 2
Clinical conclusion
Melatonin has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.
The conclusion and evidence-signal classification are distinct authoritative fields and are reproduced as published.
Observed effects
Observed study estimates; not a pooled treatment effect.
Between-group effect
Absolute change
0 to 0 %
Between-group effect
Mean difference
-1.3 to -1.3 %
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 0
- Magnitude-eligible effects
- 2
Consistency
Authoritative consistency classification
mostly_consistent
- Positive
- 1
- No effect
- 2
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 3 of 3 supporting studies. 2 studies described participants with type 2 diabetes. 2 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Adults aged 30-65 with type 2 diabetes
- Patients diagnosed with chronic periodontitis
- Adults diagnosed with type 2 diabetes.
- Participants who were not on melatonin prior to the study.
- Night workers potentially at risk for diabetes.
- Individuals seeking interventions for diabetes risk management.
Limitations
- 1 supporting study does not have a displayable topic-matched quantitative effect.
- 3 of 3 studies with duration data have follow-up of 12 weeks or less.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.