Browse by outcome

HbA1c Reduction

Choose an intervention dossier to evaluate the supplied synthesis and supporting evidence.

This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.

41 dossiers195 included studies54 limited studies

41 of 41 dossiers shown

Clinical Reference

Low-carbohydrate diet

Low-carbohydrate diet → HbA1c

Low-carbohydrate diet shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Structured multidisciplinary case management

Structured multidisciplinary case management → HbA1c

Structured multidisciplinary case management shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

SRP + OHI

SRP + OHI → HbA1c

SRP + OHI has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Lifestyle intervention for prediabetes

Lifestyle intervention for prediabetes → HbA1c

Lifestyle intervention for prediabetes shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 8 supporting studies
Open dossier
Clinical Reference

Metformin + glimepiride

Metformin + glimepiride → HbA1c

Metformin + glimepiride shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Dulaglutide

Dulaglutide → HbA1c

Dulaglutide shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Calorie restriction

Calorie restriction → HbA1c

Calorie restriction shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Instructional WhatsApp group for diabetes self-care

Instructional WhatsApp group for diabetes self-care → HbA1c

Instructional WhatsApp group for diabetes self-care shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Metformin

Metformin → HbA1c

Metformin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 11 supporting studies
Open dossier
Clinical Reference

Empagliflozin

Empagliflozin → HbA1c

Empagliflozin shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 8 supporting studies
Open dossier
Clinical Reference

Hybrid closed-loop system

Hybrid closed-loop system → HbA1c

Hybrid closed-loop system shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

DSMES

DSMES → HbA1c

DSMES has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 8 supporting studies
Open dossier
Clinical Reference

Exercise therapy

Exercise therapy → HbA1c

Exercise therapy shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 8 supporting studies
Open dossier
Clinical Reference

Aerobic exercise

Aerobic exercise → HbA1c

Aerobic exercise shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Liraglutide

Liraglutide → HbA1c

Liraglutide shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Glimepiride

Glimepiride → HbA1c

Glimepiride has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Multispecies probiotic supplementation

Multispecies probiotic supplementation → HbA1c

Multispecies probiotic supplementation shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Non-surgical periodontal treatment

Non-surgical periodontal treatment → HbA1c

Non-surgical periodontal treatment shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
mixed
Supporting studies: 13 supporting studies
Open dossier
Clinical Reference

Time-Restricted Eating (TRE)

Time-Restricted Eating (TRE) → HbA1c

Time-Restricted Eating (TRE) has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Resistance training

Resistance training → HbA1c

Resistance training shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Tirzepatide

Tirzepatide → HbA1c

Tirzepatide shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 12 supporting studies
Open dossier
Clinical Reference

Dipeptidyl peptidase-4 inhibitors

Dipeptidyl peptidase-4 inhibitors → HbA1c

Dipeptidyl peptidase-4 inhibitors shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Melatonin

Melatonin → HbA1c

Melatonin has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi)

Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) → HbA1c

Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Usual care

Usual care → HbA1c

Usual care has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
consistent
Supporting studies: 10 supporting studies
Open dossier
Clinical Reference

Mobile app for diabetes self-management

Mobile app for diabetes self-management → HbA1c

Mobile app for diabetes self-management shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Remote multiprofessional educational program

Remote multiprofessional educational program → HbA1c

Remote multiprofessional educational program shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Basal insulin

Basal insulin → HbA1c

Basal insulin has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mostly_consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Sitagliptin

Sitagliptin → HbA1c

Sitagliptin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Pioglitazone

Pioglitazone → HbA1c

Pioglitazone shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Semaglutide

Semaglutide → HbA1c

Semaglutide shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 11 supporting studies
Open dossier
Clinical Reference

Intermittent Fasting (IF)

Intermittent Fasting (IF) → HbA1c

Intermittent Fasting (IF) shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Dapagliflozin

Dapagliflozin → HbA1c

Dapagliflozin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 6 supporting studies
Open dossier
Clinical Reference

Insulin therapy

Insulin therapy → HbA1c

Insulin therapy shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 4 supporting studies
Open dossier
Clinical Reference

Rama Diabetes Care app

Rama Diabetes Care app → HbA1c

Rama Diabetes Care app has not shown a clear effect on HbA1c in the available evidence.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Continuous glucose monitoring

Continuous glucose monitoring → HbA1c

Continuous glucose monitoring shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 7 supporting studies
Open dossier
Clinical Reference

SMS text messaging behavioral intervention for health promotion

SMS text messaging behavioral intervention for health promotion → HbA1c

SMS text messaging behavioral intervention for health promotion shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 5 supporting studies
Open dossier
Clinical Reference

Insulin degludec

Insulin degludec → HbA1c

Insulin degludec shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

mHealth diabetes support intervention

mHealth diabetes support intervention → HbA1c

mHealth diabetes support intervention has a small positive evidence signal for HbA1c, but the clinical interpretation is limited.

ConsistencyScore™
mixed
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Multi-species synbiotic (12 probiotic strains + FOS prebiotic)

Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c

Multi-species synbiotic (12 probiotic strains + FOS prebiotic) shows a strong positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
consistent
Supporting studies: 3 supporting studies
Open dossier
Clinical Reference

Vitamin D supplementation

Vitamin D supplementation → HbA1c

Vitamin D supplementation shows a moderate positive evidence signal for improving HbA1c across the studied comparisons.

ConsistencyScore™
mostly_consistent
Supporting studies: 5 supporting studies
Open dossier