Clinical evidence dossier
Sitagliptin
HbA1c
Evidence signal
Authoritative evidence signal
strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 3
- Supporting studies available for review
- 3
- Randomized trials
- 2
- Reported effects
- 14
Clinical conclusion
Sitagliptin shows a strong positive evidence signal for improving HbA1c across the studied comparisons.
Observed effects
Observed study estimates; not a pooled treatment effect.
Between-group effect
Mean difference
-0.159 to -0.159 %
Change from baseline
Mean difference
-11 to -2 mmol/mol
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 1
- Magnitude-eligible effects
- 5
Consistency
Authoritative consistency classification
consistent
- Positive
- 3
- No effect
- 0
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 3 of 3 supporting studies. 3 studies described participants with type 2 diabetes. 3 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Korean adults aged 18-75 with type 2 diabetes.
- Individuals not achieving glycemic control with other treatments.
- Adults with type 2 diabetes inadequately controlled with metformin.
- Patients seeking alternative oral medications for diabetes management.
- Adults diagnosed with type 2 diabetes.
- Patients receiving conventional diabetes therapy.
Limitations
- 1 relevant study has unresolved authoritative design evidence and does not contribute to design-specific or RoB-specific claims.
- Evidence uses heterogeneous comparison contexts: active_comparator, usual_care.
- 2 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.