Clinical evidence dossier
Tirzepatide
Body weight
Evidence signal
Evidence signal
Strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 12
- Supporting studies available for review
- 12
- Randomized trials
- 11
- Reported effects
- 30
Clinical conclusion
Tirzepatide shows a strong positive evidence signal for improving Body weight across the studied comparisons.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Absolute change
−6.8% to −6.8%
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 1
- Magnitude-eligible effects
- 3
Consistency
Consistency classification
Consistent
- Positive
- 12
- No effect
- 0
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 12 of 12 supporting studies. Diabetes type was heterogeneous: 10 studies with type 2 diabetes, 1 studies with type 1 diabetes. 11 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Adults diagnosed with type 2 diabetes.
- Patients currently using dulaglutide for diabetes management.
- Adults aged 18 and older with obesity or overweight.
- Individuals seeking pharmacological interventions for weight management.
- Bangladeshi patients with Type 2 diabetes.
- Individuals observing Ramadan fasting.
- Patients seeking improved glycemic control and weight management.
- Patients seeking alternatives to insulin therapy.
- Patients seeking effective weight management solutions.
- Adults with early-onset Type 2 diabetes.
- Individuals seeking effective weight management strategies.
- Korean patients diagnosed with type 2 diabetes.
Limitations
- Evidence uses heterogeneous comparison contexts: active_comparator, baseline_within_group, placebo, usual_care.
- 10 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.