Clinical Reference
Metformin
Metformin → BMI
Metformin shows a moderate positive evidence signal for improving BMI across the studied comparisons.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 3 supporting studies
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Weight Loss
Choose an intervention dossier to evaluate the supplied synthesis and supporting evidence.
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
24 dossiers110 included studies36 limited studies
24 of 24 dossiers shown
Clinical Reference
Tirzepatide
Tirzepatide → Body weight
Tirzepatide shows a strong positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 11 supporting studies
Open dossierClinical Reference
Dapagliflozin
Dapagliflozin → BMI
Dapagliflozin shows a strong positive evidence signal for improving BMI across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Aerobic exercise
Aerobic exercise → BMI
Aerobic exercise shows a moderate positive evidence signal for improving BMI across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Calorie restriction
Calorie restriction → Waist circumference
Calorie restriction shows a strong positive evidence signal for improving Waist circumference across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Liraglutide
Liraglutide → Body weight
Liraglutide shows a strong positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 5 supporting studies
Open dossierClinical Reference
Lifestyle intervention for prediabetes
Lifestyle intervention for prediabetes → Waist circumference
Lifestyle intervention for prediabetes has a small positive evidence signal for Waist circumference, but the clinical interpretation is limited.
- ConsistencyScore™
- consistent
Supporting studies: 4 supporting studies
Open dossierClinical Reference
Lifestyle intervention for prediabetes
Lifestyle intervention for prediabetes → BMI
Lifestyle intervention for prediabetes has a small positive evidence signal for BMI, but the clinical interpretation is limited.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Very-low-calorie ketogenic diet
Very-low-calorie ketogenic diet → Waist circumference
Very-low-calorie ketogenic diet shows a strong positive evidence signal for improving Waist circumference across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Dulaglutide
Dulaglutide → BMI
Dulaglutide has a small positive evidence signal for BMI, but the clinical interpretation is limited.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Liraglutide
Liraglutide → BMI
Liraglutide shows a moderate positive evidence signal for improving BMI across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Empagliflozin
Empagliflozin → Body weight
Empagliflozin shows a moderate positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 5 supporting studies
Open dossierClinical Reference
Calorie restriction
Calorie restriction → Body weight
Calorie restriction shows a moderate positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 5 supporting studies
Open dossierClinical Reference
Lifestyle intervention for prediabetes
Lifestyle intervention for prediabetes → Body weight
Lifestyle intervention for prediabetes has a small positive evidence signal for Body weight, but the clinical interpretation is limited.
- ConsistencyScore™
- consistent
Supporting studies: 9 supporting studies
Open dossierClinical Reference
Dipeptidyl peptidase-4 inhibitors
Dipeptidyl peptidase-4 inhibitors → Body weight
Dipeptidyl peptidase-4 inhibitors shows a strong positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 4 supporting studies
Open dossierClinical Reference
Resistance training
Resistance training → Lean body mass
Resistance training shows a moderate positive evidence signal for improving Lean body mass across the studied comparisons.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Exercise therapy
Exercise therapy → Lean body mass
Exercise therapy has not shown a clear effect on Lean body mass in the available evidence.
- ConsistencyScore™
- mixed
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Very-low-calorie ketogenic diet
Very-low-calorie ketogenic diet → Body weight
Very-low-calorie ketogenic diet shows a strong positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Tirzepatide
Tirzepatide → Waist circumference
Tirzepatide shows a moderate positive evidence signal for improving Waist circumference across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Usual care
Usual care → Body weight
Usual care has not shown a clear effect on Body weight in the available evidence.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Metformin
Metformin → Body weight
Metformin has a small positive evidence signal for Body weight, but the clinical interpretation is limited.
- ConsistencyScore™
- mostly_consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Time-Restricted Eating (TRE)
Time-Restricted Eating (TRE) → Body weight
Time-Restricted Eating (TRE) shows a strong positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 3 supporting studies
Open dossierClinical Reference
Semaglutide
Semaglutide → BMI
Semaglutide shows a moderate positive evidence signal for improving BMI across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 4 supporting studies
Open dossierClinical Reference
Semaglutide
Semaglutide → Body weight
Semaglutide shows a moderate positive evidence signal for improving Body weight across the studied comparisons.
- ConsistencyScore™
- consistent
Supporting studies: 9 supporting studies
Open dossier