Supporting evidence

Dipeptidyl peptidase-4 inhibitors × Body weight

Authoritative support: 4
Available studies: 4
Unavailable support: 0

Available supporting studies

Study 1 · Included

Empagliflozin reduces HbA1c in youth with type 2 diabetes

Rct

Comparison: Drug naïve adolescents receiving empagliflozin for 26 weeks. · Drug naïve adolescents receiving linagliptin for 26 weeks. · Drug naïve adolescents receiving placebo for 26 weeks. · Young adults receiving empagliflozin for 24 weeks. · Young adults receiving sitagliptin for 24 weeks. · Young adults receiving placebo for 24 weeks.
Duration / follow-up: 884 weeks

Relevant effects

Mean difference

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Study 2 · Included

Sitagliptin/Empagliflozin Improves Glycemic Control in Type 2 Diabetes

Rct

Comparison: Participants received metformin + sitagliptin placebo + DW1026C1 + DW1026C2 placebo. · Participants received metformin + sitagliptin placebo + DW1026C2 + DW1026C1 placebo. · Participants received metformin + sitagliptin 100 mg + DW1026C1 placebo + DW1026C2 placebo.
Duration / follow-up: 52 weeks

Relevant effects

Mean difference

2.82 · 0.0001

Mean difference

2.55 · 0.0001

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Study 3 · Included

Vildagliptin and Metformin Improve Glycemic Control in Type 2 Diabetes

Rct

Comparison: Patients received 50 mg of vildagliptin orally twice daily. · Patients received 500 mg of metformin orally twice daily with meals, with dosage adjustable.
Duration / follow-up: 26 weeks

Relevant effects

Absolute change

5.79 · 0.001

Absolute change

2.14 · 0.009

Absolute change

1.02 · 0.001

Absolute change

1.54 · 0.001

Absolute change

5.79 · 0.001

Absolute change

2.14 · 0.009

Absolute change

1.02 · 0.001

Absolute change

1.54 · 0.001

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Study 4 · Limited

Vildagliptin improves insulin resistance and weight in type 2 diabetes

Rct

Comparison: Patients who received gliclazide in combination with metformin. · Patients who received vildagliptin in combination with metformin.
Duration / follow-up: 13 weeks

Relevant effects

Percent change

2.58 · 0.001

Percent change

0 · 0.45

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