Structured population data were available for 3 of 3 supporting studies. 2 studies described participants with type 2 diabetes. 3 studies described adult participants.

Evidence uses heterogeneous comparison contexts: placebo, usual_care.

2 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.

Standard Care

Core clinician-reference fields are available or not applicable.

Participants treated with tirzepatide for weight management.

Tirzepatide Treatment

In SURMOUNT-1, 81.8 % of participants treated with tirzepatide (pooled 10 mg/15 mg) shifted at least one BMI category lower.

Participants receiving standard care for obesity management.

The SURMOUNT clinical trials assessed in these analyses were SURMOUNT-1 (NCT04184622) and SURMOUNT-4 (NCT04660643).

Authoritative quality diagnostic: invalid or missing unit.

Authoritative quality diagnostic: invalid or missing value.

Tirzepatide improves cardiometabolic health in obesity.

Comparator Interventions

Participants received once-weekly tirzepatide treatment.

Participants were randomly assigned to receive once-weekly tirzepatide (5 mg, 10 mg, or 15 mg) or one of the following comparator interventions: semaglutide (1 mg), insulin degludec, or placebo.

Participants received either semaglutide, insulin degludec, or placebo.

Tirzepatide improves glycemic control in early-onset type 2 diabetes

Placebo Control

Participants receiving once weekly tirzepatide treatment for type 2 diabetes.

Baseline characteristics and change from baseline to week 40/42 for efficacy parameters were described and analyzed in treatment-adherent participants (≥75% doses administered and on treatment at week 40/42) receiving once weekly tirzepatide (5 mg, 10 mg, or 15 mg) (N = 3,188).

Participants receiving placebo treatment.

The primary efficacy measure of HbA1c reduction from baseline was superiority of tirzepatide compared with placebo or noninferiority of tirzepatide compared with active comparators.

Tirzepatide × Waist circumference

Available supporting studies

Tirzepatide improves cardiometabolic health in obesity.

Tirzepatide improves glycemic control in early-onset type 2 diabetes

Tirzepatide improves weight loss in adults with type 2 diabetes