Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Aerobic Exercise and Saffron Improve Insulin Resistance in Obese Women
Última actualización 3 de julio de 2026
Key finding
HOMA-IR showed significant reduction in the ST, PT, and SS groups compared to the P group (p < 0.001).
This study investigated the effects of aerobic exercise and saffron supplementation on insulin resistance and inflammation in obese women with type 2 diabetes, finding significant improvements in several health markers.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of aerobic exercise and saffron supplementation on insulin resistance and inflammation in obese women with type 2 diabetes, finding significant improvements in several health markers.
Clinical relevance
These findings are clinically significant as they suggest that integrating saffron supplementation with aerobic exercise could be an effective strategy for improving metabolic health in obese women with type 2 diabetes. This could lead to better management of diabetes and reduction in related health risks.
Keep in mind
The study's sample size may limit the generalizability of the findings. The long-term effects of saffron supplementation were not assessed. Potential confounding factors were not fully controlled.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Ali R, Ali ANG, Elham M, et al. Effects of Aerobic Exercise and Saffron Supplementation on Hemostasis, Inflammation, and Insulin Resistance in Obese Women with Type 2 Diabetes. European Journal of Sport Science. 2024;24(7):899-906. doi:10.1002/ejsc.12125
Efectos Principales
HOMA-IR showed significant reduction in saffron plus training, placebo plus training, and saffron supplementation groups compared to placebo (p < 0.001).
Serum glucose levels significantly decreased in saffron plus training, placebo plus training, and saffron supplementation groups compared to placebo (p < 0.001).
Inflammatory markers such as interleukin-6 and TNF-alpha significantly reduced in saffron and training groups compared to placebo (p < 0.001).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Exercise therapy and Fibrinogen, Homocysteine, Insulin resistance, and 3 more.
This study contributes evidence to
Primary intervention
Exercise therapy
Primary outcomes
- Fibrinogen
- Homocysteine
- Insulin resistance
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
6
Evidence pairs
615
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Insulin Resistance
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
Prediabetes
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerTumor Necrosis Factor-alpha (TNF-α)
Exercise therapy → Tumor Necrosis Factor-alpha (TNF-α)
Exercise therapy → Tumor Necrosis Factor-alpha (TNF-α)
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerEvidence Library
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Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- HOMA-IR decreased by -1.5 index in saffron and training groups (p < 0.001).
- Serum glucose levels decreased by -2 mmol/L in saffron and training groups (p < 0.001).
- Fibrinogen levels decreased by -0.5 g/L in saffron and training groups (p < 0.001).
A quién se aplica
- Obese women aged 30-60 with type 2 diabetes.
- Individuals seeking alternative methods to manage diabetes.
- Patients interested in combining dietary supplements with exercise.
Tener en Cuenta
- Results may not apply to non-obese individuals or men.
- Further research is needed to confirm long-term benefits.
- The study did not explore the effects of saffron alone without exercise.
Entre Líneas
- The study's sample size may limit the generalizability of the findings.
- The long-term effects of saffron supplementation were not assessed.
- Potential confounding factors were not fully controlled.
Evidence Library
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Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Exercise therapy and Inflammatory Markers, Exercise therapy and Inflammatory Markers.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Exercise therapy → Inflammatory Markers
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Estudios de apoyo: Basado en 4 estudios
View evidencePhysical Activity
Exercise therapy → Inflammatory Markers
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Exercise therapy Evidence Hub
All studies on Exercise therapy
4 studies
intervention_hubContributes to Exercise therapy evidence base.
Inflammatory Markers Evidence Hub
All studies measuring Inflammatory Markers
4 studies
outcome_hubMeasures Inflammatory Markers as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Exercise therapy and Interleukin-6 (IL-6)
Intervention: Exercise therapyOutcome: Interleukin-6 (IL-6)
4 results
All studies on Exercise therapy and Tumor Necrosis Factor-alpha (TNF-α)
Intervention: Exercise therapyOutcome: Tumor Necrosis Factor-alpha (TNF-α)
3 results
All studies on Exercise therapy
Intervention: Exercise therapy
4 results
All studies measuring Interleukin-6 (IL-6)
Outcome: Interleukin-6 (IL-6)
4 results
All studies measuring Tumor Necrosis Factor-alpha (TNF-α)
Outcome: Tumor Necrosis Factor-alpha (TNF-α)
3 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Exercise therapy improve interleukin-6 (il-6)?
Strong Evidence
Exercise therapy appears to improve Interleukin-6 (IL-6).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Interleukin-6 (IL-6)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve tumor necrosis factor-alpha (tnf-α)?
Strong Evidence
Exercise therapy may improve Tumor Necrosis Factor-alpha (TNF-α).
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Tumor Necrosis Factor-alpha (TNF-α)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve insulin resistance?
Moderate Evidence
Exercise therapy appears to improve Insulin resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve fibrinogen?
Emerging Evidence
Exercise therapy appears to improve Fibrinogen.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fibrinogen
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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