Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Canagliflozin with metformin reduces cardiovascular risk in T2DM
Última actualización 6 de julio de 2026
Key finding
The incidence of MACE in the observation group (5.17%) was significantly lower than that in the control group (12.93%).
This study evaluated the effects of canagliflozin combined with metformin on cardiovascular risk in patients with type 2 diabetes mellitus, finding a significant reduction in major adverse cardiovascular events.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
Guarda este estudio en tu Evidence Tracker para encontrarlo facilmente cuando lo necesites.
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the effects of canagliflozin combined with metformin on cardiovascular risk in patients with type 2 diabetes mellitus, finding a significant reduction in major adverse cardiovascular events.
Clinical relevance
These findings are crucial as they suggest that combining canagliflozin with metformin not only helps manage blood sugar levels in type 2 diabetes but also reduces the risk of serious heart problems. This could lead to better long-term health outcomes for patients with diabetes, emphasizing the importance of effective treatment strategies in this population.
Keep in mind
The study's sample size may limit the generalizability of the findings. The long-term effects of the treatment were not assessed. Potential confounding factors were not fully controlled.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Xiaoyu C, Yimin S, Xuebo L. The impact and safety of canagliflozin combined with metformin on reducing cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Diabetology & Metabolic Syndrome. 2024;16:199. doi:10.1186/s13098-024-01438-1
Efectos Principales
The incidence of major adverse cardiovascular events (MACE) was significantly lower in the canagliflozin group (5.17%) compared to the placebo group (12.93%).
Glycated hemoglobin (HbA1c) decreased significantly by 1.09% (p=0.001) from baseline.
Systolic blood pressure (SBP) decreased significantly by 6.15 mmHg (p=0.002) from baseline.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Canagliflozin combined with Metformin, Metformin combined with Placebo and BMI, Composite cardiovascular events (CV death, MI, stroke, HF hospitalization), Diastolic blood pressure, and 10 more.
This study contributes evidence to
Primary intervention
Canagliflozin combined with Metformin
Primary outcomes
- BMI
- Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
- Diastolic blood pressure
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
13
Evidence pairs
13
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
13
Evidence pairs
332
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 13 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Agrega evidencia relacionada a tu Evidence Tracker
Guarda estudios y paginas de evidencia, organiza tu Evidence Tracker y manten en un solo lugar la investigacion que te importa.
Evidencia principal
Tema de evidencia
Cardiovascular Risk
matched_outcome
Evidencia relacionada
Tema de evidencia
HbA1c Reduction
Seguir evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Canagliflozin combined with Metformin → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Canagliflozin combined with Metformin → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerDiastolic blood pressure
Canagliflozin combined with Metformin → Diastolic blood pressure
Canagliflozin combined with Metformin → Diastolic blood pressure
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEstimated glomerular filtration rate
Canagliflozin combined with Metformin → Estimated glomerular filtration rate
Canagliflozin combined with Metformin → Estimated glomerular filtration rate
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerHDL cholesterol
Canagliflozin combined with Metformin → HDL cholesterol
Canagliflozin combined with Metformin → HDL cholesterol
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerLDL cholesterol
Canagliflozin combined with Metformin → LDL cholesterol
Canagliflozin combined with Metformin → LDL cholesterol
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSystolic blood pressure
Canagliflozin combined with Metformin → Systolic blood pressure
Canagliflozin combined with Metformin → Systolic blood pressure
Evidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerAdverse events incidence
Metformin combined with Placebo → Adverse events incidence
Metformin combined with Placebo → Adverse events incidence
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerAll-cause mortality
Metformin combined with Placebo → All-cause mortality
Metformin combined with Placebo → All-cause mortality
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerHospitalization rate
Metformin combined with Placebo → Hospitalization rate
Metformin combined with Placebo → Hospitalization rate
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of non-cardiovascular death
Metformin combined with Placebo → Incidence of non-cardiovascular death
Metformin combined with Placebo → Incidence of non-cardiovascular death
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncidence of severe adverse reactions
Metformin combined with Placebo → Incidence of severe adverse reactions
Metformin combined with Placebo → Incidence of severe adverse reactions
Evidence Intelligence™
- ImpactScore™
- 50
- Neutral
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerBuild your personal Evidence Workspace
Create a free account to save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Today's Activity
Your Evidence Workspace
Saved this study
Your free account becomes your personal diabetes evidence workspace.
Evidence Tracker
12 tracked topics
Saved Studies
48 studies
Research Notes
Coming Soon
Weekly Evidence Digest
Coming Soon
La Evidencia Sugiere
- Canagliflozin reduced MACE incidence by 7.76 percentage points (p=0.05).
- HbA1c levels decreased significantly by 1.09% (p=0.001).
- SBP decreased significantly by 6.15 mmHg (p=0.002).
A quién se aplica
- Adults diagnosed with type 2 diabetes mellitus.
- Patients at risk of cardiovascular events due to diabetes.
Tener en Cuenta
- Results may not apply to populations outside the study sample.
- The study did not include long-term follow-up data.
- Further research is needed to confirm these findings in diverse populations.
Entre Líneas
- The study's sample size may limit the generalizability of the findings.
- The long-term effects of the treatment were not assessed.
- Potential confounding factors were not fully controlled.
Save this study
Keep this study in your Evidence Tracker so you can easily find it again whenever you need it.
Today's Activity
Your Evidence Workspace
Saved this study
Your free account becomes your personal diabetes evidence workspace.
Evidence Tracker
12 tracked topics
Saved Studies
48 studies
Research Notes
Coming Soon
Weekly Evidence Digest
Coming Soon
Already have an account?
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Canagliflozin combined with Metformin and Body Mass Index, Canagliflozin combined with Metformin and Cardiovascular Outcomes.
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceMedications
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceMedications
Detailed evidenceEvidence Intelligence™
- ImpactScore™
- 100
- Very Positive
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Blood Pressure Evidence Hub
All studies measuring Blood Pressure
1 studies
outcome_hubMeasures Blood Pressure as a key outcome.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
1 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Canagliflozin combined with Metformin Evidence Hub
All studies on Canagliflozin combined with Metformin
1 studies
intervention_hubContributes to Canagliflozin combined with Metformin evidence base.
Cardiovascular Outcomes Evidence Hub
All studies measuring Cardiovascular Outcomes
1 studies
outcome_hubMeasures Cardiovascular Outcomes as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en el archivo de evidencia
Jump to pre-filtered views in the evidence archive.
All studies on Canagliflozin combined with Metformin and BMI
Intervention: Canagliflozin combined with MetforminOutcome: BMI
1 results
All studies on Canagliflozin combined with Metformin and Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Intervention: Canagliflozin combined with MetforminOutcome: Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
1 results
All studies on Canagliflozin combined with Metformin
Intervention: Canagliflozin combined with Metformin
1 results
All studies measuring BMI
Outcome: BMI
1 results
All studies measuring Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Outcome: Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Canagliflozin combined with Metformin affect bmi?
Emerging Evidence
Canagliflozin combined with Metformin appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Canagliflozin combined with Metformin improve composite cardiovascular events (cv death, mi, stroke, hf hospitalization)?
Emerging Evidence
Canagliflozin combined with Metformin appears to improve Composite cardiovascular events (CV death, MI, stroke, HF hospitalization).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Canagliflozin combined with Metformin improve diastolic blood pressure?
Emerging Evidence
Canagliflozin combined with Metformin appears to improve Diastolic blood pressure.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Diastolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Canagliflozin combined with Metformin improve estimated glomerular filtration rate?
Emerging Evidence
Canagliflozin combined with Metformin appears to improve Estimated glomerular filtration rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
Continue your research
Choose a next path through related evidence topics, archive views, and research summaries.
Evidence topics
Follow the topics this study contributes to.
Explore in archive
Open broader archive views for this relationship.
All studies on Canagliflozin combined with Metformin and Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)All studies on Canagliflozin combined with Metformin and BMIAll studies on Canagliflozin combined with Metformin and Diastolic blood pressureAll studies on Canagliflozin combined with Metformin and Estimated glomerular filtration rate
Related research
Read related research summaries.
Mediterranean ketogenic eating matched VLCKD for weight loss over 3 monthsCombined Antioxidant and Prebiotic Supplementation Improves T2 Diabetes OutcomesEarly use of effective therapies may improve diabetes outcomesGLP-1 agonists reduce heart fat thickness in diabetes.Mobile health intervention improves kidney function in diabetes
No ads. No tracking.
Focused on evidence, not advertising.
Secure & private
Your data is always protected.
Always up to date
New studies added every day.