Última actualización 1 de julio de 2026
Key finding
Carnosine supplementation resulted in improvement of depressive symptoms assessed by total PHQ-8 score (mean difference = -2.0; 95% CI: -3.9, -0.2; p = 0.03).
This study investigated the effects of carnosine supplementation on depressive symptoms in individuals with prediabetes and well-controlled type 2 diabetes, finding a significant reduction in depressive symptoms.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of carnosine supplementation on depressive symptoms in individuals with prediabetes and well-controlled type 2 diabetes, finding a significant reduction in depressive symptoms.
Depressive symptoms are common in individuals with diabetes and can significantly impact their quality of life and disease management. This study suggests that carnosine supplementation could be a beneficial adjunctive treatment for reducing depressive symptoms in this population, potentially improving overall mental health and adherence to diabetes management strategies.
The sample size and demographic characteristics may limit generalizability. The study did not assess long-term effects of carnosine supplementation. Potential confounding factors were not fully controlled for.
Published in
Publication details and source links for this paper.
Robel HK, Jack F, Aya M, et al. Carnosine supplementation may improve depressive symptoms in individuals with prediabetes and well-controlled type 2 diabetes. Food Science & Nutrition. 2026;14(3):e71514. doi:10.1002/fsn3.71514
Carnosine supplementation improved depressive symptoms with a mean difference of -2.0 in total PHQ-8 score (p = 0.03).
No significant changes in total PHQ-8 score were observed in the placebo group (p > 0.05).
Health-related quality of life scores showed no significant changes in either group (p > 0.05).
Evidence network
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This study contributes evidence to Curcumin supplementation and Health-related quality of life, Total PHQ-8 score.
This study contributes evidence to
Primary intervention
Curcumin supplementation
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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Evidence pairs
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Evidencia principal
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Intervención
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Resultado
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Core evidence
The primary outcomes reported in this study.
Curcumin supplementation → Health-related quality of life
Curcumin supplementation → Health-related quality of life
Curcumin supplementation → Total PHQ-8 score
Curcumin supplementation → Total PHQ-8 score
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Quality of Life Outcomes, Curcumin Supplements and Total PHQ-8 score.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
All studies measuring Total PHQ-8 score
Measures Total PHQ-8 score as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements may improve Quality of Life Outcomes.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Health-related quality of life
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Curcumin supplementation appears to improve Total PHQ-8 score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Total PHQ-8 score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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