Última actualización 5 de julio de 2026
Key finding
CLE supplementation resulted in a significant reduction in neuropathy symptom score compared with placebo (P = 0.048).
This study evaluated the effects of Curcuma longa extract on neuropathy symptoms and vascular biomarkers in adults with type 2 diabetes, finding significant improvements in several measures.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the effects of Curcuma longa extract on neuropathy symptoms and vascular biomarkers in adults with type 2 diabetes, finding significant improvements in several measures.
These findings suggest that Curcuma longa extract could be a beneficial supplement for adults with type 2 diabetes, potentially improving their quality of life by alleviating neuropathy symptoms and reducing inflammation, which are common complications of the disease.
The study may have limited generalizability due to a specific participant demographic. The sample size and duration of the study may not capture long-term effects. Potential biases in self-reported outcomes could affect the reliability of symptom scores.
Published in
Publication details and source links for this paper.
Drielly RV, Alanna RM, Cristina AS, Maria DCF. Effects of Curcuma longa extract supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus: A randomized double-blind placebo-controlled trial. European Journal of Nutrition. 2026;65(3):116. doi:10.1007/s00394-026-03963-3
Curcuma longa extract reduced neuropathy symptom score by 1.5 points (P = 0.048).
Curcuma longa extract significantly decreased Syndecan-1 levels by 46.5 ng/mL (P = 0.001).
Curcuma longa extract significantly reduced Hyaluronic acid levels by 68.1 ng/mL (P = 0.002).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Curcuma longa extract (CLE) and Hyaluronic acid (HA), Matrix metalloproteinase-2 (MMP-2), Matrix metalloproteinase-9 (MMP-9), and 8 more.
This study contributes evidence to
Primary intervention
Curcuma longa extract (CLE)
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
11
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Curcuma longa extract (CLE) → Hyaluronic acid (HA)
Curcuma longa extract (CLE) → Hyaluronic acid (HA)
Curcuma longa extract (CLE) → Matrix metalloproteinase-2 (MMP-2)
Curcuma longa extract (CLE) → Matrix metalloproteinase-2 (MMP-2)
Curcuma longa extract (CLE) → Matrix metalloproteinase-9 (MMP-9)
Curcuma longa extract (CLE) → Matrix metalloproteinase-9 (MMP-9)
Curcuma longa extract (CLE) → Neuropathy symptom score
Curcuma longa extract (CLE) → Neuropathy symptom score
Curcuma longa extract (CLE) → Nuclear factor erythroid 2-related factor 2 (Nrf2)
Curcuma longa extract (CLE) → Nuclear factor erythroid 2-related factor 2 (Nrf2)
Curcuma longa extract (CLE) → Nuclear factor kappa B (NF-κB p65)
Curcuma longa extract (CLE) → Nuclear factor kappa B (NF-κB p65)
Curcuma longa extract (CLE) → Sirtuin-1 (SIRT1)
Curcuma longa extract (CLE) → Sirtuin-1 (SIRT1)
Curcuma longa extract (CLE) → Syndecan-1 (SDC1)
Curcuma longa extract (CLE) → Syndecan-1 (SDC1)
Curcuma longa extract (CLE) → Syndecan-4 (SDC4)
Curcuma longa extract (CLE) → Syndecan-4 (SDC4)
Curcuma longa extract (CLE) → Thioredoxin-1 (Trx1)
Curcuma longa extract (CLE) → Thioredoxin-1 (Trx1)
Curcuma longa extract (CLE) → Thioredoxin-binding protein-2 (TBP2)
Curcuma longa extract (CLE) → Thioredoxin-binding protein-2 (TBP2)
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Saved this study
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Evidence Tracker
12 tracked topics
Saved Studies
48 studies
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcuma longa extract (CLE) and Hyaluronic acid (HA), Curcuma longa extract (CLE) and Matrix metalloproteinase-2 (MMP-2).
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Curcuma longa extract (CLE)
Contributes to Curcuma longa extract (CLE) evidence base.
All studies measuring Hyaluronic acid (HA)
Measures Hyaluronic acid (HA) as a key outcome.
All studies measuring Matrix metalloproteinase-2 (MMP-2)
Measures Matrix metalloproteinase-2 (MMP-2) as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcuma longa extract (CLE) appears to improve Hyaluronic acid (HA).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Hyaluronic acid (HA)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Curcuma longa extract (CLE) appears to improve Matrix metalloproteinase-2 (MMP-2).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Matrix metalloproteinase-2 (MMP-2)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Curcuma longa extract (CLE) appears to improve Matrix metalloproteinase-9 (MMP-9).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Matrix metalloproteinase-9 (MMP-9)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Curcuma longa extract (CLE) appears to improve Neuropathy symptom score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Neuropathy symptom score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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