Resumen de Investigación
Dapagliflozin-linagliptin combo improves glycemic control and organ protection
Moderate confidence
Low bias
Última actualización 19 de junio de 2026Conclusión Clave:
This study evaluated the combination therapy of Dapagliflozin and Linagliptin in managing Type 2 Diabetes and hypertension, showing significant improvements in various health metrics.
Estudio de un Vistazo
Qué se estudió
Dapagliflozin-linagliptin combination therapy in adults with type 2 diabetes and hypertension.
Participantes
Middle Aged (40-64)
Male, Female
with T2 Diabetes
Intervención
Dapagliflozin
Resultados
Time in range, HbA1c, Fasting Plasma Glucose (FPG), Systolic blood pressure, Triglycerides, ALT, Urinary albumin-to-creatinine ratio, Estimated glomerular filtration rate
Financiamiento
No Patrocinado por la Industria
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Efectos Principales
Combination therapy achieved a time in range of 94.86%, significantly higher than ~80% in monotherapies (P<0.001).
HbA1c levels decreased to 5.52%, indicating improved glycemic control.
Systolic blood pressure reduced to 124 mmHg, demonstrating effective hypertension management.
Resumen de Evidencia
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Dapagliflozin (Medications) |  Alanine Aminotransferase (ALT) (Metabolic Health) | Decrease | Strong |
Dapagliflozin (Medications) |  Estimated glomerular filtration rate (Clinical Outcomes) | Increase | Strong |
Dapagliflozin (Medications) |  Fasting Plasma Glucose (FPG) (Glycemic Control) | Decrease | Strong |
Dapagliflozin (Medications) | HbA1c (Glycemic Control) | Decrease | Strong |
Dapagliflozin (Medications) | Systolic blood pressure (Metabolic Health) | Decrease | Strong |
Dapagliflozin (Medications) | Time in range (Glycemic Control) | Increase | Strong |
Dapagliflozin (Medications) | Triglycerides (Metabolic Health) | Decrease | Strong |
Dapagliflozin (Medications) | Urinary albumin-to-creatinine ratio (Clinical Outcomes) | Decrease | Strong |
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La Evidencia Sugiere
- Time in range improved to 94.86% with combination therapy (P<0.001).
- HbA1c reduced by 3.31% to 5.52% (P<0.001).
- Systolic blood pressure decreased by 27.2 mmHg to 124 mmHg (P<0.001).
A quién se aplica
- Adults diagnosed with Type 2 Diabetes.
- Patients also experiencing hypertension.
Tener en Cuenta
- The study's non-randomized design limits causal conclusions.
- Findings may not apply to younger populations or those with different comorbidities.
- Further research is needed to confirm long-term effects.
Entre Líneas
- Non-randomized design may introduce bias.
- Results may not be generalizable to all populations.
- Limited long-term follow-up data.
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Referencia de la Revista
WenXia L, RuRan L, ShanShan L, et al. Combination Therapy with Dapagliflozin and Linagliptin for Type 2 Diabetes and Hypertension. Frontiers in Endocrinology. 2026;17. doi:10.3389/fendo.2026.1802641
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on SGLT2 Inhibitors and Glycemic Control, SGLT2 Inhibitors and Alanine Aminotransferase (ALT).
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Incluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Glycemic Control Evidence Hub
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outcome_hubMeasures Glycemic Control as a key outcome.
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intervention_hubContributes to SGLT2 Inhibitors evidence base.
Blood Pressure Evidence Hub
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outcome_hubMeasures Blood Pressure as a key outcome.
Alanine Aminotransferase (ALT) Evidence Hub
All studies measuring Alanine Aminotransferase (ALT)
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outcome_hubMeasures Alanine Aminotransferase (ALT) as a key outcome.
Recent Diabetes Research
Latest published studies
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Published within the last 2 years.
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Preguntas que esta evidencia ayuda a responder
Key clinical and research questions this study contributes to.
Does dapagliflozin improve HbA1c?
Based on connected evidence for Dapagliflozin and HbA1c.
Does dapagliflozin affect Alanine Aminotransferase (ALT) in people with diabetes?
Exploring evidence on Dapagliflozin and Alanine Aminotransferase (ALT) outcomes.
What does the evidence say about dapagliflozin and Systolic blood pressure?
Review of studies examining Dapagliflozin and Systolic blood pressure.
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