Última actualización 21 de agosto de 2026
Key finding
Glycerol 3-phosphate showed a significant decrease (log2FC = -2.05) at 12 months compared to baseline.
This study investigated the impact of metformin on gut microbiota in prediabetic patients, revealing significant decreases in various metabolites over 12 months.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
Guarda investigacion, organiza estudios y vuelve a encontrar evidencia importante rapidamente.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of metformin on gut microbiota in prediabetic patients, revealing significant decreases in various metabolites over 12 months.
Understanding how metformin affects gut microbiota is crucial for optimizing treatment strategies in prediabetic patients. Since gut health is linked to metabolic disorders, these findings could lead to improved management of prediabetes and potentially reduce the risk of progression to type 2 diabetes.
The study had a limited sample size, which may affect the generalizability of the findings. Only one arm was defined, limiting comparisons with control groups. The long-term effects beyond 12 months were not assessed.
Published in
Publication details and source links for this paper.
Juan JO, Cristian P, Jorge EA, et al. Genome-scale community metabolic modeling reveals dietary modulation of gut microbiota in prediabetic patients treated with metformin. Computational and Structural Biotechnology Journal. 2026;31:250-262. doi:10.1016/j.csbj.2025.12.034
Glycerol 3-phosphate showed a significant decrease (log2FC = -2.05) at 12 months compared to baseline.
Hydrogen phosphate showed a significant decrease (log2FC = -4.83) at 12 months compared to baseline.
Indole showed a significant decrease (log2FC = -0.88) at 12 months compared to baseline.
Ornithine was the only metabolite with a significantly higher predicted exchange flux at 12 months (log2FC = +2.09).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Metformin and Changes in gut microbiota metabolic activity, Decrease in Indole Levels, Decrease in predicted exchange flux of L-asparagine, and 5 more.
This study contributes evidence to
Primary intervention
Metformin
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
8
Evidence pairs
29
Related studies
Evidence topic
Contributes evidence
Guarda estudios y paginas de evidencia, organiza tu Evidence Tracker y manten en un solo lugar la investigacion que te importa.
Evidencia principal
Tema de evidencia
matched_intervention
Core evidence
The primary outcomes reported in this study.
Metformin → Changes in gut microbiota metabolic activity
Metformin → Changes in gut microbiota metabolic activity
Metformin → Decrease in predicted exchange flux of L-asparagine
Metformin → Decrease in predicted exchange flux of L-asparagine
Metformin → Predicted exchange flux of glycerol 3-phosphate
Metformin → Predicted exchange flux of glycerol 3-phosphate
Metformin → Predicted exchange flux of hydrogen phosphate
Metformin → Predicted exchange flux of hydrogen phosphate
Metformin → Predicted exchange flux of L-tryptophan
Metformin → Predicted exchange flux of L-tryptophan
Metformin → Predicted exchange flux of N-acetyl-D-glucosamine
Metformin → Predicted exchange flux of N-acetyl-D-glucosamine
Metformin → Predicted Exchange Flux of Ornithine
Metformin → Predicted Exchange Flux of Ornithine
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Metformin Therapies and Predicted exchange flux of glycerol 3-phosphate, Metformin Therapies and Changes in gut microbiota metabolic activity.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Changes in gut microbiota metabolic activity
Measures Changes in gut microbiota metabolic activity as a key outcome.
All studies on Metformin Therapies
Contributes to Metformin Therapies evidence base.
All studies measuring Predicted exchange flux of glycerol 3-phosphate
Measures Predicted exchange flux of glycerol 3-phosphate as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Metformin appears to improve Changes in gut microbiota metabolic activity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Changes in gut microbiota metabolic activity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Metformin appears to improve Decrease in Indole Levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Decrease in Indole Levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Metformin appears to improve Decrease in predicted exchange flux of L-asparagine.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Decrease in predicted exchange flux of L-asparagine
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Metformin appears to improve Predicted Exchange Flux of Ornithine.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Predicted Exchange Flux of Ornithine
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Centrada en la evidencia, no en la publicidad.
Tus datos siempre están protegidos.
Se agregan nuevos estudios todos los días.
