Última actualización 11 de septiembre de 2026
Key finding
Participants considered the DiRECT intervention an acceptable approach to weight loss.
The Diabetes Remission Clinical Trial (DiRECT) evaluated a dietitian-supported low-energy total diet replacement intervention for participants with diabetes, focusing on weight loss and dietary changes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The Diabetes Remission Clinical Trial (DiRECT) evaluated a dietitian-supported low-energy total diet replacement intervention for participants with diabetes, focusing on weight loss and dietary changes.
The findings highlight the potential of structured dietary interventions in managing diabetes, emphasizing the role of personalized dietetic support. This approach may improve patient outcomes and promote sustainable weight loss, which is critical for diabetes management.
The effectiveness of the intervention remains unclear due to limited quantitative data. Findings may not be generalizable beyond the study population. Challenges during food reintroduction were noted but not quantitatively assessed.
Published in
Publication details and source links for this paper.
Kate C, Meredith P, Natalie A, et al. The Diabetes Remission Clinical Trial (DiRECT): A Pilot Randomised Controlled Trial of a Dietitian-Supported Low-Energy Total Diet Replacement Intervention. Nutrients. 2024;16(12):1853. doi:10.3390/nu16121853
Participants found the DiRECT intervention acceptable for weight loss.
Rapid improvements in weight were reported during the total diet replacement phase.
Individualized dietetic support was crucial for success.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to DiRECT intervention, Usual care and Acceptability of mHealth intervention, Challenges during food reintroduction, Patient-reported outcomes, and 3 more.
This study contributes evidence to
Primary intervention
DiRECT intervention
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
152
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
DiRECT intervention → Acceptability of mHealth intervention
DiRECT intervention → Acceptability of mHealth intervention
DiRECT intervention → Challenges during food reintroduction
DiRECT intervention → Challenges during food reintroduction
DiRECT intervention → Patient-reported outcomes
DiRECT intervention → Patient-reported outcomes
DiRECT intervention → Weight loss dependent effect on HbA1c
DiRECT intervention → Weight loss dependent effect on HbA1c
Usual care → Nutrition education effectiveness
Usual care → Nutrition education effectiveness
Usual care → Physical activity level (MET-minutes per week)
Usual care → Physical activity level (MET-minutes per week)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on DiRECT intervention and Acceptability of mHealth intervention, DiRECT intervention and Challenges during food reintroduction.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Acceptability of mHealth intervention
Measures Acceptability of mHealth intervention as a key outcome.
All studies measuring Challenges during food reintroduction
Measures Challenges during food reintroduction as a key outcome.
All studies on DiRECT intervention
Contributes to DiRECT intervention evidence base.
All studies measuring Weight loss dependent effect on HbA1c
Measures Weight loss dependent effect on HbA1c as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
DiRECT intervention appears to improve acceptability of mhealth intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Acceptability of mHealth intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Usual care appears to improve nutrition education effectiveness.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Nutrition education effectiveness
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of DiRECT intervention for challenges during food reintroduction.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Challenges during food reintroduction
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of DiRECT intervention for patient-reported outcomes.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Patient-reported outcomes
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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