Última actualización 6 de julio de 2026
Key finding
Hazard ratio 0.87, 95% confidence interval 0.67 to 1.17; P=0.39
This study evaluated the effectiveness of eldecalcitol in preventing type 2 diabetes in adults with impaired glucose tolerance. It found no significant difference in diabetes incidence between eldecalcitol and placebo groups.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effectiveness of eldecalcitol in preventing type 2 diabetes in adults with impaired glucose tolerance. It found no significant difference in diabetes incidence between eldecalcitol and placebo groups.
Understanding whether eldecalcitol can prevent type 2 diabetes is crucial, especially for individuals with impaired glucose tolerance who are at higher risk. The findings suggest that while eldecalcitol may improve bone health, it may not be effective for diabetes prevention, highlighting the need for alternative strategies in managing diabetes risk.
The study's follow-up duration may not capture long-term effects. Results may not be generalizable to populations outside the study sample. Effectiveness of eldecalcitol for diabetes prevention remains unclear.
Published in
Publication details and source links for this paper.
Tetsuya K, Gen S, Shoichi M, et al. Eldecalcitol for the prevention of type 2 diabetes in adults with impaired glucose tolerance: a randomized controlled trial. The BMJ. 2022;377:e066222. doi:10.1136/bmj-2021-066222
Eldecalcitol group had a 12.5% incidence of type 2 diabetes compared to 14.2% in the placebo group (hazard ratio 0.87).
23.0% of eldecalcitol participants achieved regression to normoglycaemia versus 20.1% in the placebo group (hazard ratio 1.15).
Bone mineral density of lumbar spine and femoral neck significantly increased with eldecalcitol (P<0.001).
Evidence network
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This study contributes evidence to Eldecalcitol and Bone mineral density (BMD), Regression to normoglycaemia, Serum osteocalcin, and 1 more.
This study contributes evidence to
Primary intervention
Eldecalcitol
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
18
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
Eldecalcitol → Bone mineral density (BMD)
Eldecalcitol → Bone mineral density (BMD)
Eldecalcitol → Regression to normoglycaemia
Eldecalcitol → Regression to normoglycaemia
Eldecalcitol → Type 2 diabetes incidence
Eldecalcitol → Type 2 diabetes incidence
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Eldecalcitol and Bone Mineral Density, Eldecalcitol and Regression to normoglycaemia.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Bone Mineral Density
Measures Bone Mineral Density as a key outcome.
All studies on Eldecalcitol
Contributes to Eldecalcitol evidence base.
All studies measuring Regression to normoglycaemia
Measures Regression to normoglycaemia as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Eldecalcitol appears to improve Bone mineral density (BMD).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bone mineral density (BMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Eldecalcitol appears to improve Serum osteocalcin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum osteocalcin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Eldecalcitol for Regression to normoglycaemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Regression to normoglycaemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Eldecalcitol for Type 2 diabetes incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Type 2 diabetes incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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