Última actualización 4 de julio de 2026
Key finding
Mean HbA1c levels decreased to 6.21 ± 0.62% in the test arm and 6.26 ± 0.64% in the reference arm, with a mean reduction of -2.20 ± 0.91%.
This study evaluated the efficacy and safety of generic semaglutide compared to innovator semaglutide in Indian adults with type 2 diabetes inadequately controlled on metformin, finding non-inferior results.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy and safety of generic semaglutide compared to innovator semaglutide in Indian adults with type 2 diabetes inadequately controlled on metformin, finding non-inferior results.
This study highlights the potential of generic semaglutide as an effective alternative to innovator semaglutide for managing type 2 diabetes, which could improve access to treatment for patients in India. With a significant proportion of participants achieving target HbA1c levels, it emphasizes the importance of affordable options in diabetes care.
The study was limited to Indian adults, which may affect generalizability to other populations. Sample size and duration may not capture long-term effects or rare adverse events. The study did not assess the cost-effectiveness of generic versus innovator semaglutide.
Published in
Publication details and source links for this paper.
Nitin K, Shehla S, Saptarshi B, et al. Generic semaglutide demonstrated non-inferior efficacy and comparable safety to innovator Semaglutide in Indian adults with T2DM inadequately controlled on metformin. Cardiovascular diabetology. Endocrinology reports. 2026;12:21. doi:10.1186/s40842-026-00290-8
Mean HbA1c levels decreased to 6.21 ± 0.62% in the test arm and 6.26 ± 0.64% in the reference arm, with a mean reduction of -2.20 ± 0.91%.
A total of 86.62% of participants achieved HbA1c < 7.0%.
Safety profiles were comparable, with predominantly mild-to-moderate adverse events.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Semaglutide and Adverse events incidence, Body weight, Fasting Plasma Glucose (FPG), and 3 more.
This study contributes evidence to
Primary intervention
Semaglutide
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
7
Related topics
6
Evidence pairs
1915
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Contributes evidence
Evidence topic
Contributes evidence
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Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
Evidencia relacionada
Relación de evidencia
Guardar evidencia
Relación de evidencia
Guardar evidencia
Core evidence
The primary outcomes reported in this study.
Semaglutide → Adverse events incidence
Semaglutide → Adverse events incidence
Semaglutide → Fasting Plasma Glucose (FPG)
Semaglutide → Fasting Plasma Glucose (FPG)
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Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and HbA1c, GLP-1 Receptor Agonists and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies on GLP-1 Receptor Agonists
Contributes to GLP-1 Receptor Agonists evidence base.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
12 results
9 results
12 results
12 results
9 results
Generated from the study's connected evidence using Evidence Intelligence™.
GLP-1 Receptor Agonists appear to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.6 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 33 supporting studies with consistent results and a positive effect signal.
GLP-1 Receptor Agonists may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.5 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 33 supporting studies with consistent results and a positive effect signal.
GLP-1 Receptor Agonists may improve fasting glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 14 supporting studies with generally consistent results and a positive effect signal.
GLP-1 Receptor Agonists may affect hypoglycemia.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Hypoglycemia events
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
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