Última actualización 4 de septiembre de 2026
Key finding
HbA1c decreased from 8.20 ± 0.64 to 7.09 ± 0.48 after 12 weeks.
This study investigated the effects of high-intensity interval training (HIIT) on patients with diabetic peripheral neuropathy, showing significant improvements in various metabolic markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of high-intensity interval training (HIIT) on patients with diabetic peripheral neuropathy, showing significant improvements in various metabolic markers.
The findings highlight the potential of high-intensity interval training as a viable exercise option for patients with diabetic peripheral neuropathy, a condition that often complicates diabetes management. Improved metabolic markers such as glycated hemoglobin and inflammatory cytokines can lead to better overall health outcomes, reducing the risk of complications associated with diabetes.
The study had a limited sample size, which may affect the generalizability of the findings. The duration of the intervention was relatively short, limiting long-term conclusions. Potential confounding factors were not fully controlled, which may influence the outcomes.
Published in
Publication details and source links for this paper.
Genchun G, Zhenhua Z, Xin S, et al. The Effects of High-Intensity Interval Training on Patients with Diabetic Peripheral Neuropathy: A Randomized Controlled Trial. Frontiers in Endocrinology. 2026;17:1879941. doi:10.3389/fendo.2026.1879941
Glycated Hemoglobin (HbA1c) decreased from 8.20 ± 0.64 to 7.09 ± 0.48 (p=0.001).
Fasting Plasma Glucose (FPG) decreased from 9.12 ± 1.21 to 6.82 ± 0.80 (p=0.001).
Tumor Necrosis Factor-alpha (TNF-α) decreased from 8.68 ± 1.54 to 3.68 ± 0.91 (p=0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to High-intensity interval exercise, Moderate continuous exercise and Berg Balance Scale, C-reactive protein, Change in motor nerve conduction velocity (MCV) from baseline, and 7 more.
This study contributes evidence to
Primary intervention
High-intensity interval exercise
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
6
Related topics
20
Evidence pairs
1681
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
Evidencia relacionada
Relación de evidencia
Guardar evidencia
Relación de evidencia
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Core evidence
The primary outcomes reported in this study.
High-intensity interval exercise → Berg Balance Scale
High-intensity interval exercise → Berg Balance Scale
High-intensity interval exercise → C-reactive protein
High-intensity interval exercise → C-reactive protein
High-intensity interval exercise → Change in motor nerve conduction velocity (MCV) from baseline
High-intensity interval exercise → Change in motor nerve conduction velocity (MCV) from baseline
High-intensity interval exercise → Change in sensory nerve conduction velocity from baseline
High-intensity interval exercise → Change in sensory nerve conduction velocity from baseline
High-intensity interval exercise → Fasting Plasma Glucose (FPG)
High-intensity interval exercise → Fasting Plasma Glucose (FPG)
High-intensity interval exercise → Insulin resistance
High-intensity interval exercise → Insulin resistance
High-intensity interval exercise → Interleukin-6 (IL-6)
High-intensity interval exercise → Interleukin-6 (IL-6)
High-intensity interval exercise → Toronto Clinical Scoring System (TCSS)
High-intensity interval exercise → Toronto Clinical Scoring System (TCSS)
High-intensity interval exercise → Tumor Necrosis Factor-alpha (TNF-α)
High-intensity interval exercise → Tumor Necrosis Factor-alpha (TNF-α)
Moderate continuous exercise → Berg Balance Scale
Moderate continuous exercise → Berg Balance Scale
Moderate continuous exercise → C-reactive protein
Moderate continuous exercise → C-reactive protein
Moderate continuous exercise → Change in motor nerve conduction velocity (MCV) from baseline
Moderate continuous exercise → Change in motor nerve conduction velocity (MCV) from baseline
Moderate continuous exercise → Change in sensory nerve conduction velocity from baseline
Moderate continuous exercise → Change in sensory nerve conduction velocity from baseline
Moderate continuous exercise → Fasting Plasma Glucose (FPG)
Moderate continuous exercise → Fasting Plasma Glucose (FPG)
Moderate continuous exercise → Insulin resistance
Moderate continuous exercise → Insulin resistance
Moderate continuous exercise → Interleukin-6 (IL-6)
Moderate continuous exercise → Interleukin-6 (IL-6)
Moderate continuous exercise → Toronto Clinical Scoring System (TCSS)
Moderate continuous exercise → Toronto Clinical Scoring System (TCSS)
Moderate continuous exercise → Tumor Necrosis Factor-alpha (TNF-α)
Moderate continuous exercise → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on High-intensity interval exercise and HbA1c, High-intensity interval exercise and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on High-intensity interval exercise
Contributes to High-intensity interval exercise evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
5 results
4 results
5 results
5 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Aerobic Exercise appears to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 78.7 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 11 supporting studies with consistent results and a positive effect signal.
Aerobic Exercise appears to improve fasting glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Aerobic Exercise may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Aerobic Exercise appears to improve inflammatory markers.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Interleukin-6 (IL-6)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Tumor Necrosis Factor-alpha (TNF-α)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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