Resumen de Investigación
Analyzed using Evidence Intelligence™

Intensive lifestyle intervention improves diabetes remission in India

Última actualización 18 de agosto de 2026

Key finding

Weight decreased by 8.5% in the remission group compared to 5.2% in the non-remission group.

BL21 probiotic added to metformin in adults with type 2 diabetes.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Short-Term (≤3 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

BL21 probiotic added to metformin in adults with type 2 diabetes.

Clinical relevance

This study evaluated BL21 probiotic added to metformin in adults with type 2 diabetes.

Keep in mind

Limitations were not clearly described in the extracted text.

Published in

Referencia de la Revista

Publication details and source links for this paper.

Pramod T, Nidhi K, Thejas K, et al. Predictors of type 2 diabetes remission following intensive lifestyle intervention in an Indian population. PLOS One. 2025;20(10):e0333114. doi:10.1371/journal.pone.0333114

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Lifestyle intervention for prediabetes and BMI, Body weight, Fasting insulin levels, and 3 more.

Primary intervention

Lifestyle intervention for prediabetes

Primary outcomes

  • BMI
  • Body weight
  • Fasting insulin levels

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

6
Evidence pairs
6
Relationships
3
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 72

3

Related topics

6

Evidence pairs

836

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 6 evidence relationships
  • Includes primary outcome data
  • Linked to 3 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

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Evidencia principal

Tema de evidencia

Prediabetes

matched_intervention_and_outcome

Evidencia relacionada

Tema de evidencia

Weight Loss

Guardar evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

BMI

Lifestyle intervention for prediabetes → BMI

Lifestyle intervention for prediabetes → BMI

Evidence Intelligence™
EvidenceScore™
Strong
Score 79 · Based on 3 studies
ImpactScore™
67
Slightly Positive
ConsistencyScore™
67
generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence Tracker

Body weight

Lifestyle intervention for prediabetes → Body weight

Lifestyle intervention for prediabetes → Body weight

Evidence Intelligence™
EvidenceScore™
84
Strong
ImpactScore™
67
Slightly Positive
ConsistencyScore™
78
consistent
Estudios de apoyo: Basado en 9 estudios
Add to Evidence Tracker

Fasting insulin levels

Lifestyle intervention for prediabetes → Fasting insulin levels

Lifestyle intervention for prediabetes → Fasting insulin levels

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
75
Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

HbA1c

Lifestyle intervention for prediabetes → HbA1c

Lifestyle intervention for prediabetes → HbA1c

Evidence Intelligence™
EvidenceScore™
85
Strong
ImpactScore™
83
Positive
ConsistencyScore™
78
consistent
Estudios de apoyo: Basado en 9 estudios
Add to Evidence Tracker

Homeostatic Model Assessment of Beta-cell function (HOMA-β)

Lifestyle intervention for prediabetes → Homeostatic Model Assessment of Beta-cell function (HOMA-β)

Lifestyle intervention for prediabetes → Homeostatic Model Assessment of Beta-cell function (HOMA-β)

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Insulin resistance

Lifestyle intervention for prediabetes → Insulin resistance

Lifestyle intervention for prediabetes → Insulin resistance

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Lifestyle intervention for prediabetes and HbA1c, Lifestyle intervention for prediabetes and Body Weight.

Relaciones de evidencia relacionadas

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Lifestyle intervention for prediabetes improve HbA1c?

Strong Evidence

Lifestyle intervention for prediabetes may improve HbA1c.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    HbA1c

    EvidenceScore™ Strong | EvidenceScore™ 85.2 | moderate positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Lifestyle intervention for prediabetes affect body weight?

Strong Evidence

Lifestyle intervention for prediabetes may improve Body weight.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Body weight

    EvidenceScore™ Strong | EvidenceScore™ 83.6 | weak positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Lifestyle intervention for prediabetes affect bmi?

Strong Evidence

Lifestyle intervention for prediabetes may improve BMI.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    BMI

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Lifestyle intervention for prediabetes improve fasting insulin levels?

Moderate Evidence

Lifestyle intervention for prediabetes may improve Fasting insulin levels.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Fasting insulin levels

    EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026
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