PrediabetesPreventionNutrition & Diet
Resumen de Investigación

Intensive lifestyle programme cuts type 2 diabetes risk by 57% in European prediabetes trial

High confidence
Low bias
Última actualización 11 de junio de 2026

Conclusión Clave:

This study combined data from three European trials of lifestyle programmes for people with prediabetes. The lifestyle programme cut diabetes risk by 57% overall, and those who lost 5% or more of their body weight in the first year had a 65% lower risk. Keeping the weight off for longer led to even greater protection.

Estudio de un Vistazo

Qué se estudió

Effectiveness of lifestyle intervention and weight loss maintenance for T2D prevention across European EDIPS trials

Participantes

Middle Aged (40-64), Older Adults (65+)

Male, Female

with Prediabeteswith Obesity

Intervención

Lifestyle intervention for prediabetes

Resultados

Type 2 diabetes incidence, Body weight

Financiamiento

No Patrocinado por la Industria

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Efectos Principales

↓ T2D incidence by 57% in lifestyle intervention vs control (HR 0.42, 95% CI 0.29–0.60, p<0.001)

↓ T2D incidence by 65% in those with ≥5% weight loss at 1 year (HR 0.35, 95% CI 0.22–0.56, p<0.001)

Sustained ≥5% weight loss at 2–3 years associated with further risk reduction

Resumen de Evidencia

InterventionOutcomeMeasured ChangeStudy Effect
Behavioral & Lifestyle
Lifestyle intervention for prediabetes
(Behavioral & Lifestyle)
Weight & Anthropometrics
Body weight
(Weight & Anthropometrics)
Decrease
Strong
Behavioral & Lifestyle
Lifestyle intervention for prediabetes
(Behavioral & Lifestyle)
Clinical Outcomes
Type 2 diabetes incidence
(Clinical Outcomes)
Decrease
Strong

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keep in mind

Tener en Cuenta

  • Pooled analysis combines trials with some variability in intervention delivery across sites Weight loss analysis is per-protocol, not ITT — people who lost weight may have differed in other ways Limited to three European populations — may not generalise to other regions or ethnic groups Follow-up limited to mean 3.1 years
between the lines

Entre Líneas

  • Pooled analysis combines trials with some variability in intervention delivery across sites Weight loss analysis is per-protocol, not ITT — people who lost weight may have differed in other ways Limited to three European populations — may not generalise to other regions or ethnic groups Follow-up limited to mean 3.1 years

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Connected Evidence

Discover how this study fits into the broader diabetes evidence landscape.

This study contributes to evidence on Lifestyle Programs and Body Weight, Lifestyle Programs and Diabetes Incidence and Prevention.

Relaciones de evidencia relacionadas

Explore in Evidence Archive

This study contributes to the evidence on the following intervention–outcome relationships.

Preguntas que esta evidencia ayuda a responder

Key clinical and research questions this study contributes to.

Does lifestyle intervention for prediabetes improve Body weight?

Based on connected evidence for Lifestyle intervention for prediabetes and Body weight.

Does lifestyle intervention for prediabetes affect Type 2 diabetes incidence in people with diabetes?

Exploring evidence on Lifestyle intervention for prediabetes and Type 2 diabetes incidence outcomes.

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