Última actualización 1 de septiembre de 2026
Key finding
There were no significant changes in fasting plasma TMAO concentrations following inulin supplementation.
This study investigated the effects of inulin supplementation on fasting and postprandial plasma TMAO levels in participants with type 2 diabetes, finding no significant changes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of inulin supplementation on fasting and postprandial plasma TMAO levels in participants with type 2 diabetes, finding no significant changes.
Understanding the effects of dietary interventions like inulin on metabolic markers such as TMAO is crucial for developing effective dietary strategies for managing type 2 diabetes. Since TMAO has been linked to cardiovascular risk, knowing that inulin supplementation does not alter its levels can help guide dietary recommendations for patients.
The study may have limited generalizability due to a specific participant population. The sample size was not specified, which may affect the robustness of the findings. The duration of supplementation and follow-up was not detailed, which could impact results.
Published in
Publication details and source links for this paper.
Mary EB, Cortney NS, Christopher JA, et al. Trimethylamine N-Oxide (TMAO) and Type 2 Diabetes: Effects of Inulin Supplementation. Nutrients. 2018;10(6):793. doi:10.3390/nu10060793
Fasting plasma TMAO concentrations showed no significant changes following inulin supplementation.
Fasting plasma TMAO concentrations showed no significant changes following placebo.
Postprandial plasma TMAO concentrations showed no significant changes following inulin supplementation.
Postprandial plasma TMAO concentrations showed no significant changes following placebo.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Inulin supplementation, Maltodextrin placebo and Fasting plasma TMAO, Postprandial plasma TMAO.
This study contributes evidence to
Primary intervention
Inulin supplementation
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
4
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Inulin supplementation → Fasting plasma TMAO
Inulin supplementation → Fasting plasma TMAO
Inulin supplementation → Postprandial plasma TMAO
Inulin supplementation → Postprandial plasma TMAO
Maltodextrin placebo → Fasting plasma TMAO
Maltodextrin placebo → Fasting plasma TMAO
Maltodextrin placebo → Postprandial plasma TMAO
Maltodextrin placebo → Postprandial plasma TMAO
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Inulin supplementation and Fasting plasma TMAO, Inulin supplementation and Postprandial plasma TMAO.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting plasma TMAO
Measures Fasting plasma TMAO as a key outcome.
All studies on Inulin supplementation
Contributes to Inulin supplementation evidence base.
All studies measuring Postprandial plasma TMAO
Measures Postprandial plasma TMAO as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Inulin supplementation for fasting plasma tmao.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting plasma TMAO
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Inulin supplementation for postprandial plasma tmao.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Postprandial plasma TMAO
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Maltodextrin placebo for fasting plasma tmao.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting plasma TMAO
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Maltodextrin placebo for postprandial plasma tmao.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Postprandial plasma TMAO
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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