Última actualización 4 de septiembre de 2026
Key finding
Ingestion of the KEβHB beverage led to a significantly higher AUC for Apo C-II (p=0.023).
This study evaluated the effects of a ketone monoester beverage on apolipoproteins in adults with prediabetes, finding a significant increase in Apolipoprotein C-II levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of a ketone monoester beverage on apolipoproteins in adults with prediabetes, finding a significant increase in Apolipoprotein C-II levels.
Understanding how dietary supplements like ketone monoesters affect apolipoproteins is crucial for managing prediabetes. Elevated Apolipoprotein C-II may have implications for lipid metabolism and cardiovascular health, making this research relevant for dietary interventions in at-risk populations.
The study's sample size may limit the generalizability of the findings. Results may not apply to populations outside of prediabetic adults. The long-term effects of KEβHB on apolipoproteins remain unclear.
Published in
Publication details and source links for this paper.
Yutong L, Wandia K, Sakina HB, Maxim SP. Effects of a Ketone Monoester Beverage on Apolipoproteins in Adults with Prediabetes: A Randomized Placebo-Controlled Trial. Frontiers in Nutrition. 2026;12:1726174. doi:10.3389/fnut.2025.1726174
Ingestion of the KEβHB beverage led to a significantly higher AUC for Apolipoprotein C-II (p=0.023).
No statistically significant differences were found for Apolipoprotein A-I (p=0.410).
No statistically significant differences were found for Apolipoprotein B (p=0.258).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Exogenous ketone monoester (KE), Nutrient-depleted placebo beverage and Apolipoprotein B change, Apolipoprotein B-48, Apolipoprotein E, and 6 more.
This study contributes evidence to
Primary intervention
Exogenous ketone monoester (KE)
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
11
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Exogenous ketone monoester (KE) → Apolipoprotein B change
Exogenous ketone monoester (KE) → Apolipoprotein B change
Exogenous ketone monoester (KE) → Apolipoprotein B-48
Exogenous ketone monoester (KE) → Apolipoprotein B-48
Exogenous ketone monoester (KE) → Apolipoprotein E
Exogenous ketone monoester (KE) → Apolipoprotein E
Exogenous ketone monoester (KE) → Appetite Control
Exogenous ketone monoester (KE) → Appetite Control
Exogenous ketone monoester (KE) → lipoprotein(a)
Exogenous ketone monoester (KE) → lipoprotein(a)
Nutrient-depleted placebo beverage → Apolipoprotein A-I
Nutrient-depleted placebo beverage → Apolipoprotein A-I
Nutrient-depleted placebo beverage → Apolipoprotein B
Nutrient-depleted placebo beverage → Apolipoprotein B
Nutrient-depleted placebo beverage → Apolipoprotein B-48
Nutrient-depleted placebo beverage → Apolipoprotein B-48
Nutrient-depleted placebo beverage → Apolipoprotein C-II
Nutrient-depleted placebo beverage → Apolipoprotein C-II
Nutrient-depleted placebo beverage → Apolipoprotein C-III
Nutrient-depleted placebo beverage → Apolipoprotein C-III
Nutrient-depleted placebo beverage → Apolipoprotein E
Nutrient-depleted placebo beverage → Apolipoprotein E
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Exogenous ketone monoester (KE) and Apolipoprotein B-48, Exogenous ketone monoester (KE) and Apolipoprotein B change.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Apolipoprotein B change
Measures Apolipoprotein B change as a key outcome.
All studies measuring Apolipoprotein B-48
Measures Apolipoprotein B-48 as a key outcome.
All studies on Exogenous ketone monoester (KE)
Contributes to Exogenous ketone monoester (KE) evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Exogenous ketone monoester (KE) appears to improve appetite control.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Appetite Control
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Exogenous ketone monoester (KE) for apolipoprotein b change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Apolipoprotein B change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Exogenous ketone monoester (KE) for apolipoprotein b-48.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Apolipoprotein B-48
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Exogenous ketone monoester (KE) for apolipoprotein e.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Apolipoprotein E
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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