Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Low-Calorie Diet Improves Metabolic Control in Obese T2 Diabetes Patients
Última actualización 16 de agosto de 2026
Key finding
Significant loss of body weight was observed (P < 0.05).
This study investigated the effects of a low-calorie diet on metabolic control and gut microbiota in type 2 diabetes patients, finding significant weight loss and changes in gut bacteria diversity.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of a low-calorie diet on metabolic control and gut microbiota in type 2 diabetes patients, finding significant weight loss and changes in gut bacteria diversity.
Clinical relevance
These findings suggest that dietary interventions, such as a low-calorie diet, may be effective strategies for managing weight and potentially improving metabolic health in patients with type 2 diabetes, highlighting the importance of nutrition in diabetes care.
Keep in mind
Non-significant trends in some metabolic outcomes Lack of experimental validation for microbial biomarkers Results may not be generalizable to all diabetes populations
Published in
Referencia de la Revista
Publication details and source links for this paper.
Mongkontida U, Pornsawan P, Thanya C, Naraporn S. Dietary interventions can modulate the gut bacteria community and offer a complementary strategy for improving metabolic control in type 2 diabetes. Computational and Structural Biotechnology Journal. 2025;27:5307-5317. doi:10.1016/j.csbj.2025.11.043
Efectos Principales
Significant loss of body weight (-5.2 kg, p < 0.05)
Significant reduction in BMI (-1.8 kg/m², p < 0.05)
Significant loss of body fat mass (-3.5 %, p < 0.05)
Significant alterations in gut microbiota alpha diversity (p = 0.025)
Significant alterations in gut microbiota beta diversity (p = 0.002)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Very-low-calorie ketogenic diet and BMI, Body fat mass, Body weight, and 8 more.
This study contributes evidence to
Primary intervention
Very-low-calorie ketogenic diet
Primary outcomes
- BMI
- Body fat mass
- Body weight
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
11
Evidence pairs
11
Relationships
5
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
5
Related topics
11
Evidence pairs
1468
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 11 evidence relationships
- Includes primary outcome data
- Linked to 5 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Relación de evidencia
Ketogenic Diets and Body Composition
Evidencia relacionada
Relación de evidencia
Ketogenic Diets and Body Weight
Guardar evidencia
Relación de evidencia
Ketogenic Diets and Fasting Glucose
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Body fat mass
Very-low-calorie ketogenic diet → Body fat mass
Very-low-calorie ketogenic diet → Body fat mass
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerBody weight
Very-low-calorie ketogenic diet → Body weight
Very-low-calorie ketogenic diet → Body weight
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Very-low-calorie ketogenic diet → Fasting Plasma Glucose (FPG)
Very-low-calorie ketogenic diet → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerGut microbiota diversity
Very-low-calorie ketogenic diet → Gut microbiota diversity
Very-low-calorie ketogenic diet → Gut microbiota diversity
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 79
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerHospitalization rate
Very-low-calorie ketogenic diet → Hospitalization rate
Very-low-calorie ketogenic diet → Hospitalization rate
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerInferred activity in metabolic pathways
Very-low-calorie ketogenic diet → Inferred activity in metabolic pathways
Very-low-calorie ketogenic diet → Inferred activity in metabolic pathways
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerLDL cholesterol
Very-low-calorie ketogenic diet → LDL cholesterol
Very-low-calorie ketogenic diet → LDL cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerMicrobial biomarkers
Very-low-calorie ketogenic diet → Microbial biomarkers
Very-low-calorie ketogenic diet → Microbial biomarkers
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerUrinary tract infection rate
Very-low-calorie ketogenic diet → Urinary tract infection rate
Very-low-calorie ketogenic diet → Urinary tract infection rate
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Body weight decreased by 5.2 kg (p < 0.05)
- BMI reduced by 1.8 kg/m² (p < 0.05)
- Gut microbiota beta diversity increased significantly (p = 0.002)
A quién se aplica
- Adults with type 2 diabetes
- Individuals seeking dietary interventions for metabolic control
Tener en Cuenta
- The study's findings are based on a specific dietary intervention
- Results may not apply to all types of diabetes or different age groups
- Further research is needed to validate microbial biomarkers and metabolic outcomes
Entre Líneas
- Non-significant trends in some metabolic outcomes
- Lack of experimental validation for microbial biomarkers
- Results may not be generalizable to all diabetes populations
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ketogenic Diets and Body Weight, Ketogenic Diets and Fasting Glucose.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Ketogenic Diets → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
View evidenceDiet and Nutrition
Ketogenic Diets → Fasting Glucose
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
View evidenceDiet and Nutrition
Ketogenic Diets → Adipokine and Angiogenic Markers
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
3 studies
outcome_hubMeasures Body Weight as a key outcome.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
3 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Ketogenic Diets Evidence Hub
All studies on Ketogenic Diets
3 studies
intervention_hubContributes to Ketogenic Diets evidence base.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Very-low-calorie ketogenic diet and Body weight
Intervention: Very-low-calorie ketogenic dietOutcome: Body weight
3 results
All studies on Very-low-calorie ketogenic diet and Fasting Plasma Glucose (FPG)
Intervention: Very-low-calorie ketogenic dietOutcome: Fasting Plasma Glucose (FPG)
3 results
All studies on Very-low-calorie ketogenic diet
Intervention: Very-low-calorie ketogenic diet
3 results
All studies measuring Body weight
Outcome: Body weight
3 results
All studies measuring Fasting Plasma Glucose (FPG)
Outcome: Fasting Plasma Glucose (FPG)
3 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Ketogenic Diets improve body composition?
Strong Evidence
Ketogenic Diets may improve Body Composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body fat mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Ketogenic Diets affect body weight?
Strong Evidence
Ketogenic Diets appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Ketogenic Diets improve fasting glucose?
Strong Evidence
Ketogenic Diets may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Ketogenic Diets improve HbA1c?
Strong Evidence
Ketogenic Diets may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 78.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Next steps
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