Última actualización 6 de julio de 2026
Key finding
Fasting insulin levels improved compared to the placebo group.
This study investigated the effects of magnesium-containing deep seawater mineral extracts on insulin resistance in patients with impaired glucose tolerance, showing improvements in several insulin-related markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of magnesium-containing deep seawater mineral extracts on insulin resistance in patients with impaired glucose tolerance, showing improvements in several insulin-related markers.
Improving insulin sensitivity is crucial for managing conditions like prediabetes and type 2 diabetes. This study suggests that magnesium from deep seawater may be a beneficial supplement for individuals with impaired glucose tolerance, potentially aiding in the prevention of diabetes progression.
The effectiveness of the intervention remains unclear due to lack of significant findings in some glucose measures. The study's sample size and demographic may limit generalizability. No long-term effects were assessed beyond the intervention period.
Published in
Publication details and source links for this paper.
Ji YH, You KJ, Byong YJ, Yun HS, Åke S. Effects of Magnesium-Containing Deep Seawater Mineral Extracts on Insulin Resistance in Patients with Impaired Glucose Tolerance. Medicina. 2024;60(8):1265. doi:10.3390/medicina60081265
Fasting insulin levels improved compared to the placebo group.
C-peptide levels improved compared to the placebo group.
HOMA-IR values improved compared to the placebo group.
QUICKI values improved compared to the placebo group.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Deep seawater mineral extracts containing Mg 2+ and C-peptide, C-peptide incremental area under the curve (iAUC), Fasting Plasma Glucose (FPG), and 7 more.
This study contributes evidence to
Primary intervention
Deep seawater mineral extracts containing Mg 2+
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
6
Related topics
10
Evidence pairs
1247
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
Guardar evidencia
Core evidence
The primary outcomes reported in this study.
Deep seawater mineral extracts containing Mg 2+ → C-peptide
Deep seawater mineral extracts containing Mg 2+ → C-peptide
Deep seawater mineral extracts containing Mg 2+ → C-peptide incremental area under the curve (iAUC)
Deep seawater mineral extracts containing Mg 2+ → C-peptide incremental area under the curve (iAUC)
Deep seawater mineral extracts containing Mg 2+ → Fasting insulin levels
Deep seawater mineral extracts containing Mg 2+ → Fasting insulin levels
Deep seawater mineral extracts containing Mg 2+ → Fasting Plasma Glucose (FPG)
Deep seawater mineral extracts containing Mg 2+ → Fasting Plasma Glucose (FPG)
Deep seawater mineral extracts containing Mg 2+ → Glucose iAUC (OGTT)
Deep seawater mineral extracts containing Mg 2+ → Glucose iAUC (OGTT)
Deep seawater mineral extracts containing Mg 2+ → HbA1c
Deep seawater mineral extracts containing Mg 2+ → HbA1c
Deep seawater mineral extracts containing Mg 2+ → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Deep seawater mineral extracts containing Mg 2+ → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Deep seawater mineral extracts containing Mg 2+ → Insulin resistance
Deep seawater mineral extracts containing Mg 2+ → Insulin resistance
Deep seawater mineral extracts containing Mg 2+ → Insulin sensitivity
Deep seawater mineral extracts containing Mg 2+ → Insulin sensitivity
Deep seawater mineral extracts containing Mg 2+ → Stumvoll insulin sensitivity index
Deep seawater mineral extracts containing Mg 2+ → Stumvoll insulin sensitivity index
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Deep seawater mineral extracts containing Mg 2+ and C-peptide, Deep seawater mineral extracts containing Mg 2+ and Insulin Resistance.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring C-peptide
Measures C-peptide as a key outcome.
All studies on Deep seawater mineral extracts containing Mg 2+
Contributes to Deep seawater mineral extracts containing Mg 2+ evidence base.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Deep seawater mineral extracts containing Mg 2+ appears to improve Fasting insulin levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Deep seawater mineral extracts containing Mg 2+ appears to improve Insulin resistance.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Deep seawater mineral extracts containing Mg 2+ for C-peptide incremental area under the curve (iAUC).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-peptide incremental area under the curve (iAUC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Deep seawater mineral extracts containing Mg 2+ for Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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