Última actualización 6 de julio de 2026
Key finding
A significant mean difference of -0.36% in HbA1c levels between the groups (95% CI: -0.54 – -0.19, P < 0.01)
This study evaluated the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes, finding significant improvements in HbA1c and LDL-C levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes, finding significant improvements in HbA1c and LDL-C levels.
These findings highlight the importance of multifactorial interventions in managing diabetes, particularly in reducing key risk factors like HbA1c and LDL-C. Effective management of these parameters can lead to better long-term health outcomes for patients with diabetes, potentially reducing the risk of complications associated with the disease.
Limited generalizability due to the specific population studied No significant changes in blood pressure outcomes Unclear effectiveness for some outcomes
Published in
Publication details and source links for this paper.
Marwan E, Luai A, Jeffrey K, et al. Effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes. PLOS One. 2025;20(7):e0327211. doi:10.1371/journal.pone.0327211
HbA1c levels decreased by -0.36% (P < 0.01)
LDL-C levels decreased by -0.14 mmol/L (P < 0.03)
eGFR levels increased by 3.93 mL/min/1.73 m² (P < 0.01)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Multifactorial interventions and Diastolic blood pressure, Estimated glomerular filtration rate, HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Multifactorial interventions
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
310
Related studies
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Core evidence
The primary outcomes reported in this study.
Multifactorial interventions → Diastolic blood pressure
Multifactorial interventions → Diastolic blood pressure
Multifactorial interventions → Estimated glomerular filtration rate
Multifactorial interventions → Estimated glomerular filtration rate
Multifactorial interventions → LDL cholesterol
Multifactorial interventions → LDL cholesterol
Multifactorial interventions → Percentage of participants achieving blood pressure target
Multifactorial interventions → Percentage of participants achieving blood pressure target
Multifactorial interventions → Systolic blood pressure
Multifactorial interventions → Systolic blood pressure
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Multifactorial interventions and Blood Pressure, Multifactorial interventions and Kidney Function.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Kidney Function
Measures Kidney Function as a key outcome.
All studies on Multifactorial interventions
Contributes to Multifactorial interventions evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Multifactorial interventions appears to improve Estimated glomerular filtration rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Multifactorial interventions appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Multifactorial interventions appears to improve LDL cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Multifactorial interventions appears to improve Percentage of participants achieving blood pressure target.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Percentage of participants achieving blood pressure target
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
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