Última actualización 4 de julio de 2026
Key finding
HbA1c decreased from 8.36 % to 6.81 % in the test group.
This Phase 3 trial evaluated a novel semaglutide injection in Indian adults with Type 2 diabetes, showing significant reductions in HbA1c and body weight.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This Phase 3 trial evaluated a novel semaglutide injection in Indian adults with Type 2 diabetes, showing significant reductions in HbA1c and body weight.
These findings are significant as they suggest that the novel semaglutide injection could be an effective treatment option for managing Type 2 diabetes in Indian adults. By improving blood sugar control and reducing body weight, this treatment may help lower the risk of diabetes-related complications, enhancing the quality of life for patients.
The study's generalizability may be limited to the Indian population. Potential biases in self-reported outcomes were not addressed. The long-term effects of the treatment were not evaluated.
Published in
Publication details and source links for this paper.
Prabhat KS, V. V, Animesh C, et al. A Phase 3 Trial of a Novel Semaglutide Injection in Indian Adults with Type 2 Diabetes. Metabolism Open. 2026;30:100476. doi:10.1016/j.metop.2026.100476
HbA1c decreased by 1.55% in the test group (p=0.001).
Fasting plasma glucose decreased by 37.5 mg/dL in the test group.
Body weight decreased by 4.59 kg in the test group.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Semaglutide and Adverse events incidence, BMI, Body weight, and 6 more.
This study contributes evidence to
Primary intervention
Semaglutide
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
5
Related topics
9
Evidence pairs
559
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Evidencia principal
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Relación de evidencia
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Relación de evidencia
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Core evidence
The primary outcomes reported in this study.
Semaglutide → Adverse events incidence
Semaglutide → Adverse events incidence
Semaglutide → Diastolic blood pressure
Semaglutide → Diastolic blood pressure
Semaglutide → Fasting Plasma Glucose (FPG)
Semaglutide → Fasting Plasma Glucose (FPG)
Semaglutide → Postprandial hypoglycemia incidence
Semaglutide → Postprandial hypoglycemia incidence
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12 tracked topics
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Today's Activity
Saved this study
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Evidence Tracker
12 tracked topics
Saved Studies
48 studies
Research Notes
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and Body Weight, GLP-1 Receptor Agonists and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on GLP-1 Receptor Agonists
Contributes to GLP-1 Receptor Agonists evidence base.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
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Published within the last 2 years.
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11 results
12 results
11 results
11 results
12 results
Generated from the study's connected evidence using Evidence Intelligence™.
GLP-1 Receptor Agonists may improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 87.5 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 26 supporting studies with consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 87.5 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 26 supporting studies with consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 8 supporting studies with generally consistent results and a positive effect signal.
Limitations
GLP-1 Receptor Agonists may improve Hypoglycemia.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Postprandial hypoglycemia incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
Limitations
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