Última actualización 5 de julio de 2026
Key finding
Omega-3FAs-treated group recorded a more statistically significant improvement in clinical parameters compared to the control group.
This study examined the effects of omega-3 fatty acids as an adjunct to nonsurgical periodontal therapy in periodontitis patients with type II diabetes, finding significant improvements in various clinical parameters.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study examined the effects of omega-3 fatty acids as an adjunct to nonsurgical periodontal therapy in periodontitis patients with type II diabetes, finding significant improvements in various clinical parameters.
The findings suggest that incorporating omega-3 fatty acids into the treatment regimen for periodontitis in diabetic patients could enhance both periodontal and metabolic outcomes, potentially leading to improved overall health and reduced complications associated with diabetes.
The study's sample size may limit the generalizability of the findings. The duration of the study may not capture long-term effects. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Dalia G, Ahmed A, Ahmed H, Ayman E. The adjunctive use of omega-3 fatty acids with nonsurgical periodontal therapy in periodontitis patients with type II diabetes. International Journal of Dentistry. 2025;2025:7927250. doi:10.1155/ijod/7927250
Omega-3FAs treatment led to a significant decrease in HbA1c levels by 2.1% (p=0.001).
The omega-3FAs group showed a reduction in probing depth by 1.67 mm (p=0.001).
Clinical attachment loss improved significantly by 3 mm in the omega-3FAs group (p=0.001).
Evidence network
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This study contributes evidence to Omega-3 Fatty Acid Supplementation and Clinical attachment level, GCF Chemerin, Gingival Index (GI), and 4 more.
This study contributes evidence to
Primary intervention
Omega-3 Fatty Acid Supplementation
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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7
Evidence pairs
189
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Evidencia principal
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Tema de evidencia
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Intervención
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Core evidence
The primary outcomes reported in this study.
Omega-3 Fatty Acid Supplementation → Clinical attachment level
Omega-3 Fatty Acid Supplementation → Clinical attachment level
Omega-3 Fatty Acid Supplementation → GCF Chemerin
Omega-3 Fatty Acid Supplementation → GCF Chemerin
Omega-3 Fatty Acid Supplementation → Gingival Index (GI)
Omega-3 Fatty Acid Supplementation → Gingival Index (GI)
Omega-3 Fatty Acid Supplementation → Periodontal probing depth
Omega-3 Fatty Acid Supplementation → Periodontal probing depth
Omega-3 Fatty Acid Supplementation → Plaque Index (PI)
Omega-3 Fatty Acid Supplementation → Plaque Index (PI)
Omega-3 Fatty Acid Supplementation → Serum Chemerin
Omega-3 Fatty Acid Supplementation → Serum Chemerin
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This study contributes to evidence on Omega-3 Fatty Acid Supplements and Clinical attachment level, Omega-3 Fatty Acid Supplements and GCF Chemerin.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring GCF Chemerin
Measures GCF Chemerin as a key outcome.
All studies on Omega-3 Fatty Acid Supplements
Contributes to Omega-3 Fatty Acid Supplements evidence base.
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1 results
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1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Omega-3 Fatty Acid Supplements appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Omega-3 Fatty Acid Supplementation appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Omega-3 Fatty Acid Supplementation appears to improve GCF Chemerin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
GCF Chemerin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Omega-3 Fatty Acid Supplementation appears to improve Gingival Index (GI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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