Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Pioglitazone may reduce liver fat more in women than men
Última actualización 22 de julio de 2026
Key finding
Liver fat content decreased by 15.24% ± 14.54% in women (p = 0.025).
This study investigated the efficacy of pioglitazone in treating NAFLD patients with abnormal glucose metabolism, revealing significant liver fat content reduction in women compared to men.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
High Risk
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the efficacy of pioglitazone in treating NAFLD patients with abnormal glucose metabolism, revealing significant liver fat content reduction in women compared to men.
Clinical relevance
Understanding the gender differences in treatment response is crucial for optimizing therapeutic strategies for NAFLD patients. The significant reduction in liver fat content in women suggests that pioglitazone may be particularly effective for this group, potentially leading to better management of NAFLD and associated metabolic conditions.
Keep in mind
Limited sample size may affect generalizability. The study did not explore long-term effects of pioglitazone. Potential confounding factors were not fully controlled.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Hongmei Y, Weiyun W, Xinxia C, et al. Gender Differences in the Efficacy of Pioglitazone in Treating NAFLD Patients with Abnormal Glucose Metabolism. Biology of Sex Differences. 2021;12:1. doi:10.1186/s13293-020-00344-1
Efectos Principales
Liver fat content decreased by 15.24% ± 14.54% in women (p = 0.025).
Liver fat content decreased by 9.95% ± 15.18% in men (p = 0.046).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Pioglitazone and Liver fat content.
This study contributes evidence to
Primary intervention
Pioglitazone
Primary outcomes
- Liver fat content
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
1
Evidence pairs
1
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Limited contributionModerate confidenceNetwork score: 43
1
Related topics
1
Evidence pairs
9
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 1 evidence relationship
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Thiazolidinediones
matched_intervention
Core evidence
Study findings
The primary outcomes reported in this study.
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La Evidencia Sugiere
- Women showed a 15.24% decrease in liver fat (p = 0.025).
- Men showed a 9.95% decrease in liver fat (p = 0.046).
A quién se aplica
- Adults diagnosed with NAFLD.
- Patients with abnormal glucose metabolism.
Tener en Cuenta
- Results may not apply to populations outside the study sample.
- Further research is needed to confirm long-term efficacy.
- Gender differences in treatment response should be considered in clinical practice.
Entre Líneas
- Limited sample size may affect generalizability.
- The study did not explore long-term effects of pioglitazone.
- Potential confounding factors were not fully controlled.
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Connected Evidence
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Thiazolidinediones and Liver fat content.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
Thiazolidinediones → Liver fat content
Medications
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
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Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Pioglitazone improve liver fat content?
Moderate Evidence
Pioglitazone may improve Liver fat content.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Liver fat content
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Next steps
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Related research
Read related research summaries.
Saroglitazar improves liver health and glycemic control in type 2 diabetesEmpagliflozin and Pioglitazone improve heart function in diabetes patientsHealthy Nordic Diet Improves Liver Fat in Type 2 DiabetesLobeglitazone improves glycaemic control in type 2 diabetes patientsMK-3655 shows modest reduction in liver fat for pre-cirrhotic MASH
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