Última actualización 22 de agosto de 2026
Key finding
A marked increase in meal-stimulated insulin secretion was observed in the intervention group compared with controls (interaction between group and time, Gxt, p < 0.001).
This study examined the impact of a low-fat plant-based diet on beta-cell function in overweight adults without diabetes, finding significant improvements in several metabolic markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study examined the impact of a low-fat plant-based diet on beta-cell function in overweight adults without diabetes, finding significant improvements in several metabolic markers.
These findings highlight the potential of dietary interventions in improving metabolic health, particularly for overweight individuals at risk of developing diabetes. By enhancing beta-cell function and reducing insulin resistance, such dietary changes could play a crucial role in preventing diabetes and related complications.
Limited generalizability due to specific population characteristics. Short duration of the intervention may not reflect long-term effects. Potential confounding factors not fully controlled.
Published in
Publication details and source links for this paper.
Hana K, Andrea T, Martin H, Richard H, Neal DB. The Effect of a Plant-Based Dietary Intervention on Beta-Cell Function in Overweight Adults with No History of Diabetes. Nutrients. 2018;10(2):189. doi:10.3390/nu10020189
Beta-cell function increased significantly (p < 0.001).
HOMA-IR index decreased by 1.0 (p < 0.001).
Fasting plasma glucose concentrations decreased significantly (p < 0.001).
Evidence network
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This study contributes evidence to Low-fat plant-based diet and BMI, Beta-cell function, Fasting Plasma Glucose (FPG), and 3 more.
This study contributes evidence to
Primary intervention
Low-fat plant-based diet
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
944
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Evidencia principal
Tema de evidencia
matched_outcome
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Core evidence
The primary outcomes reported in this study.
Low-fat plant-based diet → Beta-cell function
Low-fat plant-based diet → Beta-cell function
Low-fat plant-based diet → Fasting insulin levels
Low-fat plant-based diet → Fasting insulin levels
Low-fat plant-based diet → Fasting Plasma Glucose (FPG)
Low-fat plant-based diet → Fasting Plasma Glucose (FPG)
Low-fat plant-based diet → Visceral Fat Reduction
Low-fat plant-based diet → Visceral Fat Reduction
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-fat plant-based diet and Beta-cell Function, Low-fat plant-based diet and Body Mass Index.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Beta-cell Function
Measures Beta-cell Function as a key outcome.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies on Low-fat plant-based diet
Contributes to Low-fat plant-based diet evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-fat plant-based diet appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low-fat plant-based diet appears to improve Beta-cell function.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Beta-cell function
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low-fat plant-based diet appears to improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Low-fat plant-based diet appears to improve HOMA-IR Index.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HOMA-IR Index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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