Última actualización 2 de julio de 2026
Key finding
Alpha diversity was analyzed with mixed-effects models, and no significant differences were observed (p > 0.05).
This study investigated the effects of Limosilactobacillus reuteri supplementation on the subgingival microbiome in diabetic patients, finding no significant alterations.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of Limosilactobacillus reuteri supplementation on the subgingival microbiome in diabetic patients, finding no significant alterations.
Understanding the effects of probiotics like Limosilactobacillus reuteri on the microbiome is crucial for managing oral health in diabetic patients. The lack of significant changes suggests that while probiotics may not directly influence the subgingival microbiome, other factors may contribute to improvements in periodontal health.
Limited sample size may affect the generalizability of findings. Short duration of the study may not capture long-term effects. Lack of significant findings limits conclusions about effectiveness.
Published in
Publication details and source links for this paper.
Rocío B, Eduardo M, Cristina C, et al. Adjunctive Limosilactobacillus reuteri Supplementation Does Not Alter Subgingival Microbiome in Diabetic Patients. Journal of Oral Microbiology. 2026;18(1):2624894. doi:10.1080/20002297.2026.2624894
No significant differences in gut microbiota alpha diversity (p > 0.05).
No significant differences in beta diversity (p > 0.05).
L. reuteri was undetectable in 10 participants across all time points.
Significant reduction in probing depth observed in both groups.
Evidence network
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This study contributes evidence to Limosilactobacillus reuteri lozenges and Beta diversity, Gut microbiota diversity, Periodontal probing depth, and 1 more.
This study contributes evidence to
Primary intervention
Limosilactobacillus reuteri lozenges
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
4
Evidence pairs
16
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Evidence topic
Contributes evidence
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Evidencia principal
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Tema de evidencia
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Intervención
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Core evidence
The primary outcomes reported in this study.
Limosilactobacillus reuteri lozenges → Beta diversity
Limosilactobacillus reuteri lozenges → Beta diversity
Limosilactobacillus reuteri lozenges → Gut microbiota diversity
Limosilactobacillus reuteri lozenges → Gut microbiota diversity
Limosilactobacillus reuteri lozenges → Periodontal probing depth
Limosilactobacillus reuteri lozenges → Periodontal probing depth
Limosilactobacillus reuteri lozenges → Relative abundance of L. reuteri
Limosilactobacillus reuteri lozenges → Relative abundance of L. reuteri
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12 tracked topics
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48 studies
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Gut Microbiota Diversity, Probiotics and Synbiotics and Gut Microbiota Diversity.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Gut Microbiota Diversity
Measures Gut Microbiota Diversity as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Gut Microbiota Diversity.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Beta diversity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Gut microbiota diversity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
Limosilactobacillus reuteri lozenges appears to improve Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Limosilactobacillus reuteri lozenges for Relative abundance of L. reuteri.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Relative abundance of L. reuteri
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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