Resumen de Investigación
Probiotics reduce GI side effects of metformin without improving metabolic efficacy
Moderate confidence
Low bias
Última actualización 19 de junio de 2026Conclusión Clave:
This study investigated whether multi-strain probiotic supplementation enhances the metabolic effects of metformin in women with elevated HOMA-IR, finding no significant improvements.
Estudio de un Vistazo
Qué se estudió
Multi-strain probiotic added to metformin in adults with type 2 diabetes.
Participantes
Young Adult (19–39), Middle Aged (40-64)
Male, Female
with T2 Diabetes
Intervención
Metformin + Multi-strain Probiotic
Resultados
Gastrointestinal symptoms frequency, Abnormal stool frequency, Hard or lumpy stools, Fasting Plasma Glucose (FPG), Insulin resistance, RBP4, Total cholesterol
Financiamiento
No Patrocinado por la Industria
Guarda este estudio y agrega notas a tu biblioteca de investigación.
Efectos Principales
Probiotic group reported 26% gastrointestinal symptoms vs. 52% in placebo (p < 0.05).
Probiotic group reported 18% abnormal stool frequency vs. 51% in placebo (p < 0.05).
No significant differences in fasting plasma glucose or insulin resistance between groups.
Resumen de Evidencia
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) |  Abnormal stool frequency (Safety) | Decrease | Strong |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) |  Fasting Plasma Glucose (FPG) (Glycemic Control) | No Change | Unclear |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) | Gastrointestinal symptoms frequency (Safety) | Decrease | Strong |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) | Hard or lumpy stools (Safety) | Decrease | Strong |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) |  Insulin resistance (Metabolic Health) | No Change | Unclear |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) | Retinol-Binding Protein 4 (RBP4) (Metabolic Health) | No Change | Unclear |
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) (Supplements) | Total cholesterol (Metabolic Health) | No Change | Unclear |
Unlock Full Evidence Analysis
Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
La Evidencia Sugiere
- Probiotic supplementation reduced gastrointestinal symptoms by 26%.
- Abnormal stool frequency decreased by 33% in the probiotic group.
- No significant changes in metabolic markers like fasting plasma glucose.
A quién se aplica
- Women diagnosed with insulin resistance or elevated HOMA-IR.
- Patients currently prescribed metformin for diabetes management.
Tener en Cuenta
- Results may not apply to men or other populations.
- The study did not assess long-term effects of probiotic use.
- Further research is needed to explore different probiotic strains or dosages.
Entre Líneas
- Limited to women with elevated HOMA-IR, affecting generalizability.
- Small sample size may limit the robustness of findings.
- Short duration of the study may not capture long-term effects.
Unlock Full Analysis
Create a free account to unlock the bias score, detailed effectiveness analysis, and clinical outcomes for this study.
Already have an account?
Referencia de la Revista
Marzena R, Agnieszka B, Katarzyna M, et al. Multi-strain Probiotic Supplementation Does Not Enhance Metabolic Efficacy of Metformin in Women with Elevated HOMA-IR. Frontiers in Endocrinology. 2026;17:1765741. doi:10.3389/fendo.2026.1765741
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Probiotics and Synbiotics and Adverse Events, Probiotics and Synbiotics and Adverse Events.
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Incluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Adverse Events Evidence Hub
All studies measuring Adverse Events
1 studies
outcome_hubMeasures Adverse Events as a key outcome.
Probiotics and Synbiotics Evidence Hub
All studies on Probiotics and Synbiotics
1 studies
intervention_hubContributes to Probiotics and Synbiotics evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en el archivo de evidencia
Jump to pre-filtered views in the evidence archive.
All studies on Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and Abnormal stool frequency
Intervention: Multi-species synbiotic (12 probiotic strains + FOS prebiotic)Outcome: Abnormal stool frequency
1 results
All studies on Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and Gastrointestinal symptoms frequency
Intervention: Multi-species synbiotic (12 probiotic strains + FOS prebiotic)Outcome: Gastrointestinal symptoms frequency
1 results
All studies on Multi-species synbiotic (12 probiotic strains + FOS prebiotic)
Intervention: Multi-species synbiotic (12 probiotic strains + FOS prebiotic)
1 results
All studies measuring Abnormal stool frequency
Outcome: Abnormal stool frequency
1 results
All studies measuring Gastrointestinal symptoms frequency
Outcome: Gastrointestinal symptoms frequency
1 results
Preguntas que esta evidencia ayuda a responder
Key clinical and research questions this study contributes to.
Does multi-species synbiotic (12 probiotic strains + fos prebiotic) improve Abnormal stool frequency?
Based on connected evidence for Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and Abnormal stool frequency.
Does multi-species synbiotic (12 probiotic strains + fos prebiotic) affect Gastrointestinal symptoms frequency in people with diabetes?
Exploring evidence on Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and Gastrointestinal symptoms frequency outcomes.
No ads. No tracking.
Focused on evidence, not advertising.
Secure & private
Your data is always protected.
Always up to date
New studies added every day.