Exercise TherapyPrediabetes
Resumen de Investigación
Analyzed using Evidence Intelligence™

Resistance training improves 2-hour glucose tolerance in older adults with prediabetes, depending on phenotype

Última actualización 15 de junio de 2026

Key finding

Chest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both<0.05).

This study tested whether prediabetes type affects how well resistance training improves blood sugar handling. 159 older adults with prediabetes did supervised strength training twice weekly for 12 weeks. 2-hour glucose tolerance improved in those with impaired glucose tolerance, but not in those with isolated impaired fasting glucose.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

non_randomized_trial

Follow-up

Short-Term (≤3 mo)

Risk of bias

High Risk

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study tested whether prediabetes type affects how well resistance training improves blood sugar handling. 159 older adults with prediabetes did supervised strength training twice weekly for 12 weeks. 2-hour glucose tolerance improved in those with impaired glucose tolerance, but not in those with isolated impaired fasting glucose.

Clinical relevance

Not everyone with prediabetes responds the same way to exercise. This study suggests that measuring 2-hour glucose tolerance could help identify who will benefit most from resistance training as part of a personalized diabetes prevention strategy.

Keep in mind

No control group (single-arm pre-post design) No HbA1c measurement, potentially missing a prediabetes phenotype Indirect measure of insulin sensitivity (Matsuda index) may not detect small changes No imaging-based measurement of visceral fat changes

Efectos Principales

↑ Muscular strength (chest press +27%, leg press +18%)

↓ Waist circumference (-1.0%) and body fat (-0.6%)

↑ Lean body mass (+1.3%)

↓ 2-hour glucose in IGT and IFG/IGT subgroups

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Resistance training and 2-hour plasma glucose, Body fat mass, Fasting blood sugar (FBS), and 5 more.

Primary intervention

Resistance training

Primary outcomes

  • 2-hour plasma glucose
  • Body fat mass
  • Fasting blood sugar (FBS)

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

8
Evidence pairs
8
Relationships
5
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

5

Related topics

8

Evidence pairs

893

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 8 evidence relationships
  • Includes primary outcome data
  • Linked to 5 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

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Evidencia principal

Tema de evidencia

Diabetic Neuropathy

matched_intervention_and_outcome

Evidencia relacionada

Tema de evidencia

Insulin Resistance

Guardar evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

2-hour plasma glucose

Resistance training → 2-hour plasma glucose

Resistance training → 2-hour plasma glucose

Evidence Intelligence™
EvidenceScore™
75
Moderate
ImpactScore™
50
Neutral
ConsistencyScore™
35
mixed
Estudios de apoyo: Basado en 3 estudios
Add to Evidence Tracker

Body fat mass

Resistance training → Body fat mass

Resistance training → Body fat mass

Evidence Intelligence™
EvidenceScore™
66
Moderate
ImpactScore™
100
Very Positive
ConsistencyScore™
35
mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Fasting blood sugar (FBS)

Resistance training → Fasting blood sugar (FBS)

Resistance training → Fasting blood sugar (FBS)

Evidence Intelligence™
EvidenceScore™
68
Moderate
ImpactScore™
55
Slightly Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Glucose iAUC (OGTT)

Resistance training → Glucose iAUC (OGTT)

Resistance training → Glucose iAUC (OGTT)

Evidence Intelligence™
EvidenceScore™
53
Emerging
ImpactScore™
55
Slightly Positive
ConsistencyScore™
unclear
Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence Tracker

Insulin sensitivity

Resistance training → Insulin sensitivity

Resistance training → Insulin sensitivity

Evidence Intelligence™
EvidenceScore™
67
Moderate
ImpactScore™
79
Positive
ConsistencyScore™
35
mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Lean body mass

Resistance training → Lean body mass

Resistance training → Lean body mass

Evidence Intelligence™
EvidenceScore™
74
Moderate
ImpactScore™
82
Positive
ConsistencyScore™
67
generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence Tracker

Muscular strength

Resistance training → Muscular strength

Resistance training → Muscular strength

Evidence Intelligence™
EvidenceScore™
76
Strong
ImpactScore™
100
Very Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence Tracker

Waist circumference

Resistance training → Waist circumference

Resistance training → Waist circumference

Evidence Intelligence™
EvidenceScore™
68
Moderate
ImpactScore™
73
Positive
ConsistencyScore™
100
consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Tracker

Evidence Library

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keep in mind

Tener en Cuenta

  • No control group (single-arm pre-post design) No HbA1c measurement, potentially missing a prediabetes phenotype Indirect measure of insulin sensitivity (Matsuda index) may not detect small changes No imaging-based measurement of visceral fat changes
between the lines

Entre Líneas

  • No control group (single-arm pre-post design) No HbA1c measurement, potentially missing a prediabetes phenotype Indirect measure of insulin sensitivity (Matsuda index) may not detect small changes No imaging-based measurement of visceral fat changes

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Resistance training and Muscular Strength, Resistance training and Postprandial and OGTT Glucose.

Relaciones de evidencia relacionadas

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Resistance training improve muscular strength?

Strong Evidence

Resistance training appears to improve Muscular strength.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Muscular strength

    EvidenceScore™ Strong | EvidenceScore™ 76.3 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Resistance training improve 2-hour plasma glucose?

Moderate Evidence

Current evidence does not show a clear benefit of Resistance training for 2-hour plasma glucose.

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    2-hour plasma glucose

    EvidenceScore™ Moderate | EvidenceScore™ 75.0 | neutral | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Resistance training affect lean body mass?

Moderate Evidence

Resistance training may improve Lean body mass.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    Lean body mass

    EvidenceScore™ Moderate | EvidenceScore™ 73.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Resistance training affect waist circumference?

Moderate Evidence

Resistance training may improve Waist circumference.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Waist circumference

    EvidenceScore™ Moderate | EvidenceScore™ 68.2 | moderate positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
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