Resumen de Investigación
Semaglutide with Insulin Improves Diabetes Control and Kidney Health
Moderate confidence
Low bias
Última actualización 17 de junio de 2026Conclusión Clave:
This study evaluated the effects of semaglutide combined with insulin therapy on glycemic control and renal function in elderly patients with type 2 diabetes, finding significant improvements in several metabolic parameters.
Estudio de un Vistazo
Participantes
Intervención
Semaglutide + Insulin Therapy
Resultados
Fasting Plasma Glucose (FPG), 2-Hour Postprandial Glucose (2hPG), HbA1c, Insulin resistance, VEGF, ET-1, 24-Hour Urinary Protein (24hUpr), Urinary Albumin-to-Creatinine Ratio (UACR), HOMA-β, Nitric Oxide (NO), Estimated Glomerular Filtration Rate (eGFR), Adverse Events
Financiamiento
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Efectos Principales
Fasting Plasma Glucose decreased by 2.31 mmol/L (p=0.001)
HbA1c decreased by 1.66% (p=0.001)
24-Hour Urinary Protein decreased significantly (p=0.001)
Resumen de Evidencia
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Insulin therapy (Medications) |  24-Hour Urinary Protein (24hUpr) (Clinical Outcomes) | Decrease | Strong |
Insulin therapy (Medications) |  Adverse events incidence (Safety) | No Change | Unclear |
Insulin therapy (Medications) |  Endothelin-1 (ET-1) (Metabolic Health) | Decrease | Strong |
Insulin therapy (Medications) | Estimated glomerular filtration rate (Clinical Outcomes) | Increase | Strong |
Insulin therapy (Medications) |  Fasting Plasma Glucose (FPG) (Glycemic Control) | Decrease | Strong |
Insulin therapy (Medications) | Glucose iAUC (OGTT) (Glycemic Control) | Decrease | Strong |
Insulin therapy (Medications) | HbA1c (Glycemic Control) | Decrease | Strong |
Insulin therapy (Medications) | Homeostatic Model Assessment of Beta-cell function (HOMA-β) (Glycemic Control) | Increase | Strong |
Insulin therapy (Medications) | Insulin resistance (Metabolic Health) | Decrease | Strong |
Insulin therapy (Medications) | Nitric Oxide (NO) (Metabolic Health) | Increase | Strong |
Insulin therapy (Medications) | Serum VEGF (Clinical Outcomes) | Decrease | Strong |
Insulin therapy (Medications) | Urinary albumin-to-creatinine ratio (Clinical Outcomes) | Decrease | Strong |
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La Evidencia Sugiere
- Fasting Plasma Glucose reduced by 2.31 mmol/L, indicating improved glycemic control.
- HbA1c decreased by 1.66%, suggesting better long-term blood sugar management.
- 24-Hour Urinary Protein levels decreased, indicating improved renal function.
A quién se aplica
- Elderly patients aged 65 and older with type 2 diabetes.
- Patients requiring insulin therapy for diabetes management.
Tener en Cuenta
- Results may not apply to younger populations or those without diabetes.
- Further studies are needed to confirm long-term benefits.
- The study's findings are based on a specific treatment regimen.
Entre Líneas
- Limited sample size may affect generalizability.
- Short duration of follow-up may not capture long-term effects.
- Unmeasured confounders could influence outcomes.
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Referencia de la Revista
Lan Y, Ying Y, Suraiya S. Semaglutide Combined with Insulin Therapy Improves Glycemic Control and Renal Function in Elderly Patients with Type 2 Diabetes. International Journal of Endocrinology. 2026;2026:1543983. doi:10.1155/ije/1543983
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Insulin Therapies and Kidney Function, Insulin Therapies and Vascular and Endothelial Function.
Relaciones de evidencia relacionadas
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
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