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Research Summary
Analyzed using Evidence Intelligence™

Mobile health intervention improves kidney function in diabetes

Powered by the Dediabetes Evidence Intelligence™ framework

Last updated July 7, 2026

Key finding

The primary outcome, change in UACR after 12 months, had a statistically and clinically significant between-group difference in change of -28.8% (P = 0.029).

This study evaluated the impact of the DialBetesPlus mobile health intervention on diabetic kidney disease, finding significant improvements in urinary albumin-to-creatinine ratio and HDL-C levels.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Long-Term (1–5 y)

Risk of bias

High Risk

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study evaluated the impact of the DialBetesPlus mobile health intervention on diabetic kidney disease, finding significant improvements in urinary albumin-to-creatinine ratio and HDL-C levels.

Clinical relevance

The findings suggest that mobile health interventions like DialBetesPlus can play a crucial role in managing diabetic kidney disease by improving key biomarkers. This could lead to better patient outcomes and reduced healthcare costs associated with kidney disease progression.

Keep in mind

The study had a limited sample size. Results may not be generalizable to all populations with diabetes. Some outcomes did not show statistically significant changes.

Published in

Journal Reference

Publication details and source links for this paper.

Kayo W, Mitsuhiko N, Syunpei E, et al. Effect of a Mobile Health Intervention on Diabetic Kidney Disease: A Randomized Controlled Trial. NPJ Digital Medicine. 2024;7:104. doi:10.1038/s41746-024-01114-8

View DOIView on PubMedView on PMC

Main Effects

Urinary albumin-to-creatinine ratio decreased by 28.8% (P = 0.029).

HbA1c percentage improved by 0.32 points (P = 0.041).

HDL-C increased by 2.8 mg/dL (P = 0.041).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to DialBetesPlus mobile health intervention and BMI, Diastolic blood pressure, Estimated glomerular filtration rate, and 5 more.

This study contributes evidence to

Intervention

DialBetesPlus mobile health intervention

Outcome

BMI

Evidence topic

Blood Pressure

Primary intervention

DialBetesPlus mobile health intervention

Primary outcomes

  • BMI
  • Diastolic blood pressure
  • Estimated glomerular filtration rate

Evidence topics

Blood PressureHbA1c ReductionWeight Loss

Primary intervention

DialBetesPlus mobile health intervention

Primary outcomes

BMIDiastolic blood pressureEstimated glomerular filtration rate

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

8
Evidence pairs
8
Relationships
3
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

3

Related topics

8

Evidence pairs

963

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 8 evidence relationships
  • Includes primary outcome data
  • Linked to 3 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Add related evidence to your Evidence Tracker

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Primary evidence

Evidence topic

Blood Pressure

matched_outcome

Related evidence

Evidence topic

HbA1c Reduction

Save evidence

Core evidence

Study findings

The primary outcomes reported in this study.

BMI

DialBetesPlus mobile health intervention → BMI

DialBetesPlus mobile health intervention → BMI

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Diastolic blood pressure

DialBetesPlus mobile health intervention → Diastolic blood pressure

DialBetesPlus mobile health intervention → Diastolic blood pressure

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Estimated glomerular filtration rate

DialBetesPlus mobile health intervention → Estimated glomerular filtration rate

DialBetesPlus mobile health intervention → Estimated glomerular filtration rate

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

HbA1c

DialBetesPlus mobile health intervention → HbA1c

DialBetesPlus mobile health intervention → HbA1c

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

HDL cholesterol

DialBetesPlus mobile health intervention → HDL cholesterol

DialBetesPlus mobile health intervention → HDL cholesterol

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Systolic blood pressure

DialBetesPlus mobile health intervention → Systolic blood pressure

DialBetesPlus mobile health intervention → Systolic blood pressure

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Triglycerides

DialBetesPlus mobile health intervention → Triglycerides

DialBetesPlus mobile health intervention → Triglycerides

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Urinary albumin-to-creatinine ratio

DialBetesPlus mobile health intervention → Urinary albumin-to-creatinine ratio

DialBetesPlus mobile health intervention → Urinary albumin-to-creatinine ratio

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Evidence Library

Build your evidence library

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evidence suggest

Evidence Suggest

  • Significant reduction in urinary albumin-to-creatinine ratio by 28.8%.
  • Improvement in HbA1c levels by 0.32 percentage points.
  • Increase in HDL-C levels by 2.8 mg/dL.
who this applies

Who this applies to

  • Adults with diabetic kidney disease.
  • Patients managing diabetes through mobile health interventions.
keep in mind

Keep in Mind

  • The intervention's effectiveness may vary by individual.
  • Long-term effects beyond 12 months are unknown.
  • Further studies are needed to confirm findings in diverse populations.
between the lines

Between the Lines

  • The study had a limited sample size.
  • Results may not be generalizable to all populations with diabetes.
  • Some outcomes did not show statistically significant changes.

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Powered by the Dediabetes Evidence Intelligence™ framework

This study contributes to evidence on DialBetesPlus mobile health intervention and Body Mass Index, DialBetesPlus mobile health intervention and Blood Pressure.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

Adipokine and Angiogenic Markers Evidence Hub

All studies measuring Adipokine and Angiogenic Markers

1 studies
outcome_hub

Measures Adipokine and Angiogenic Markers as a key outcome.

Blood Pressure Evidence Hub

All studies measuring Blood Pressure

1 studies
outcome_hub

Measures Blood Pressure as a key outcome.

Body Mass Index Evidence Hub

All studies measuring Body Mass Index

1 studies
outcome_hub

Measures Body Mass Index as a key outcome.

DialBetesPlus mobile health intervention Evidence Hub

All studies on DialBetesPlus mobile health intervention

1 studies
intervention_hub

Contributes to DialBetesPlus mobile health intervention evidence base.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does DialBetesPlus mobile health intervention improve hdl cholesterol?

Emerging Evidence

DialBetesPlus mobile health intervention appears to improve hdl cholesterol.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    HDL cholesterol

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does DialBetesPlus mobile health intervention lower HbA1c?

Emerging Evidence

DialBetesPlus mobile health intervention appears to lower HbA1c.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    HbA1c

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does DialBetesPlus mobile health intervention improve urinary albumin-to-creatinine ratio?

Emerging Evidence

DialBetesPlus mobile health intervention appears to improve urinary albumin-to-creatinine ratio.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Urinary albumin-to-creatinine ratio

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does DialBetesPlus mobile health intervention affect BMI?

Emerging Evidence

Current evidence does not show a clear effect of DialBetesPlus mobile health intervention on BMI.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    BMI

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence
Learn how Evidence Intelligence™ works

Next steps

Continue your research

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Evidence topics

Follow the topics this study contributes to.

Blood Pressure Evidence HubHbA1c Reduction Evidence HubWeight Loss Evidence Hub

Explore in Evidence Explorer

Open broader Evidence Explorer views for this relationship.

All studies on DialBetesPlus mobile health intervention and Urinary albumin-to-creatinine ratioAll studies on DialBetesPlus mobile health intervention and BMIAll studies on DialBetesPlus mobile health intervention and Diastolic blood pressureAll studies on DialBetesPlus mobile health intervention and Estimated glomerular filtration rate

Related research

Read related research summaries.

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