Research Summary

Analyzed using Evidence Intelligence™

Mobile health intervention improves kidney function in diabetes

Key finding

The primary outcome, change in UACR after 12 months, had a statistically and clinically significant between-group difference in change of -28.8% (P = 0.029).

This study evaluated the impact of the DialBetesPlus mobile health intervention on diabetic kidney disease, finding significant improvements in urinary albumin-to-creatinine ratio and HDL-C levels.

Evidence strength

Moderate confidence

Study type

RCTs

Follow-up

Long-Term (1–5 y)

High bias

Last updated July 7, 2026

Quick read

Study at a glance

The essential study design details in one scan.

Population

Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes

Intervention

DialBetesPlus mobile health intervention

Study type

RCTs

Follow-up

Long-Term (1–5 y)

Primary outcome

urinary albumin-to-creatinine ratio (UACR)

Comparator

Standard Care

Plain-language summary

What this paper says

A plain-language read of the study's main message and where it applies.

Study focus

This study evaluated the impact of the DialBetesPlus mobile health intervention on diabetic kidney disease, finding significant improvements in urinary albumin-to-creatinine ratio and HDL-C levels.

Clinical relevance

The findings suggest that mobile health interventions like DialBetesPlus can play a crucial role in managing diabetic kidney disease by improving key biomarkers. This could lead to better patient outcomes and reduced healthcare costs associated with kidney disease progression.

Keep in mind

The study had a limited sample size. Results may not be generalizable to all populations with diabetes. Some outcomes did not show statistically significant changes.

Published in

Journal Reference

Publication details and source links for this paper.

Kayo W, Mitsuhiko N, Syunpei E, et al. Effect of a Mobile Health Intervention on Diabetic Kidney Disease: A Randomized Controlled Trial. NPJ Digital Medicine. 2024;7:104. doi:10.1038/s41746-024-01114-8

View DOI View on PubMed View on PMC

Save this study and add notes to your research library.

Main Effects

Urinary albumin-to-creatinine ratio decreased by 28.8% (P = 0.029).

HbA1c percentage improved by 0.32 points (P = 0.041).

HDL-C increased by 2.8 mg/dL (P = 0.041).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to DialBetesPlus mobile health intervention and BMI, Diastolic blood pressure, Estimated glomerular filtration rate, and 5 more.

This study contributes evidence to

Intervention

DialBetesPlus mobile health intervention

Outcome

BMI

Evidence topic

HbA1c Reduction

Primary intervention

DialBetesPlus mobile health intervention

Primary outcomes

BMI
Diastolic blood pressure
Estimated glomerular filtration rate

Evidence topics

HbA1c Reduction Weight Loss

Primary intervention

DialBetesPlus mobile health intervention

Primary outcomes

BMI Diastolic blood pressure Estimated glomerular filtration rate

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 64

Why it is useful

Contributes to 8 evidence relationships
Includes primary outcome data
Linked to 2 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

DialBetesPlus mobile health intervention → Urinary albumin-to-creatinine ratio

Evidence profile

StrongDecreaseClinical Outcomes

Unlock full evidence details

Unlock full evidence analysis

Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.

Evidence Suggest

Significant reduction in urinary albumin-to-creatinine ratio by 28.8%.
Improvement in HbA1c levels by 0.32 percentage points.
Increase in HDL-C levels by 2.8 mg/dL.

Who this applies to

Adults with diabetic kidney disease.
Patients managing diabetes through mobile health interventions.

Keep in Mind

The intervention's effectiveness may vary by individual.
Long-term effects beyond 12 months are unknown.
Further studies are needed to confirm findings in diverse populations.

Between the Lines

The study had a limited sample size.
Results may not be generalizable to all populations with diabetes.
Some outcomes did not show statistically significant changes.

Unlock Full Analysis

Create a free account to unlock the bias score, detailed effectiveness analysis, and clinical outcomes for this study.

Already have an account?

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on DialBetesPlus mobile health intervention and HbA1c, DialBetesPlus mobile health intervention and Adipokine and Angiogenic Markers.

Related evidence relationships

Explore in Evidence Archive

This study contributes to the evidence on the following intervention-outcome relationships.

DialBetesPlus mobile health interventionHbA1c

Behavioral & Lifestyle

1 studies

Detailed evidence

DialBetesPlus mobile health interventionAdipokine and Angiogenic Markers

Behavioral & Lifestyle

Latest published studies

recency_collection

Published within the last 2 years.

Generated from the study's connected evidence using Evidence Intelligence™.

Does DialBetesPlus mobile health intervention improve hdl cholesterol?

Emerging Evidence

DialBetesPlus mobile health intervention appears to improve HDL cholesterol.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 50.3 | strong positive | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does DialBetesPlus mobile health intervention improve HbA1c?

Emerging Evidence

DialBetesPlus mobile health intervention appears to improve HbA1c.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 50.3 | strong positive | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does DialBetesPlus mobile health intervention improve urinary albumin-to-creatinine ratio?

Emerging Evidence

DialBetesPlus mobile health intervention appears to improve Urinary albumin-to-creatinine ratio.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Urinary albumin-to-creatinine ratio
EvidenceScore™ Emerging | EvidenceScore™ 50.3 | strong positive | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does DialBetesPlus mobile health intervention affect bmi?

Limited Evidence

Current evidence does not show a clear benefit of DialBetesPlus mobile health intervention for BMI.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
BMI
EvidenceScore™ Limited | EvidenceScore™ 32.8 | neutral | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Learn how Evidence Intelligence™ works

Next steps

Continue your research

Choose a next path through related evidence topics, archive views, and research summaries.

Evidence topics

Follow the topics this study contributes to.

HbA1c Reduction Evidence Hub Weight Loss Evidence Hub

Explore in archive

Open broader archive views for this relationship.

All studies on DialBetesPlus mobile health intervention and Urinary albumin-to-creatinine ratio All studies on DialBetesPlus mobile health intervention and HDL cholesterol All studies on DialBetesPlus mobile health intervention and HbA1c All studies on DialBetesPlus mobile health intervention and BMI

Related research

Read related research summaries.

Mediterranean ketogenic eating matched VLCKD for weight loss over 3 months Newer diabetes drugs show stronger weight and blood sugar benefits in prediabetes Canagliflozin with metformin reduces cardiovascular risk in T2DM Dapagliflozin may improve RAAS markers in diabetes patients GLP-1 agonists reduce heart fat thickness in diabetes.

No ads. No tracking.

Focused on evidence, not advertising.

Secure & private

Your data is always protected.

Always up to date

New studies added every day.