Key finding
Prebiotic group 11.0% vs. control group 21.8%; adjusted relative risk 0.50; 95% CI 0.28 to 0.89.
This study investigated how pre-pregnancy BMI influences the effect of prebiotic supplementation on gestational diabetes mellitus (GDM) rates.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Prebiotic supplementation
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Gestational diabetes mellitus (GDM) incidence in overweight/obese women
Comparator
Placebo group
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated how pre-pregnancy BMI influences the effect of prebiotic supplementation on gestational diabetes mellitus (GDM) rates.
Understanding how prebiotic supplementation interacts with pre-pregnancy BMI is crucial for developing targeted dietary recommendations for pregnant women. The findings suggest that while prebiotics may benefit overweight and obese women by lowering GDM risk, they could pose risks for normal weight women, indicating the need for personalized nutritional strategies during pregnancy.
The study may not be generalizable to all populations due to specific inclusion criteria. Sample size may limit the robustness of the findings. Unmeasured confounders could influence the outcomes.
Published in
Publication details and source links for this paper.
Rachelle AP, Thomas RS, Summer VMW, et al. Pre-pregnancy BMI modifies the effect of prebiotic supplementation on gestational diabetes mellitus rates: a randomized controlled trial. Nutrition Journal. 2026;25:62. doi:10.1186/s12937-026-01323-9
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Prebiotic supplementation reduced GDM incidence in overweight/obese women (11.0% vs. 21.8%; adjusted RR 0.50).
Normal weight women on prebiotics had higher GDM incidence compared to controls (7.7% vs. 4.4%; adjusted RR 1.72).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Prebiotic supplementation and Gestational diabetes mellitus incidence.
This study contributes evidence to
Primary intervention
Prebiotic supplementation
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
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Core evidence
The primary outcomes reported in this study.
Prebiotic supplementation → Gestational diabetes mellitus incidence
Prebiotic supplementation → Gestational diabetes mellitus incidence
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Prebiotic supplementation and Diabetes Incidence and Prevention.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Diabetes Incidence and Prevention
Measures Diabetes Incidence and Prevention as a key outcome.
All studies on Prebiotic supplementation
Contributes to Prebiotic supplementation evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Prebiotic supplementation appears to improve Gestational diabetes mellitus incidence.
ConsensusScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Gestational diabetes mellitus incidence
EvidenceScore™ Emerging | EvidenceScore™ 53.0 | strong positive | ConsensusScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
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