Key finding
The intervention group demonstrated a significant improvement in MARS-5 scores (24.23 ± 1.34) compared to the control group (19.00 ± 3.20) (P = 0.000).
Telehealth through SMS reminders significantly improved statin adherence and reduced cholesterol levels in patients with diabetes.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Telehealth through SMS reminders
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Adherence rate (MARS-5)
Comparator
Health education without SMS reminders
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
Telehealth through SMS reminders significantly improved statin adherence and reduced cholesterol levels in patients with diabetes.
Improving medication adherence is crucial for managing diabetes and preventing cardiovascular diseases. The findings suggest that simple, low-cost interventions like SMS reminders can lead to better health outcomes for patients, potentially reducing the burden of chronic diseases and healthcare costs.
The study did not measure long-term adherence beyond the intervention period. Results may not be generalizable to all diabetic populations. The impact of SMS reminders on clinical outcomes like heart events was not significant.
Published in
Publication details and source links for this paper.
Amna AD, Neama MM, Mohammad HA, Eman MH. Telehealth through SMS improves statin adherence in patients with diabetes. BMC Health Services Research. 2025;25:1150. doi:10.1186/s12913-025-13295-3
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Adherence rate improved significantly in the intervention group (MARS-5: 24.23 ± 1.34 vs. 19.00 ± 3.20, P = 0.000).
Pill count adherence increased significantly in the intervention group (99.07 ± 2.75 vs. 90.41 ± 7.68, P = 0.000).
Total cholesterol decreased significantly in the intervention group (135.26 ± 52.62 vs. 186.85 ± 54.89, P = 0.000).
LDL-c levels decreased significantly in the intervention group (71.09 ± 46.66 vs. 108.42 ± 51.93, P = 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to SMS text messaging behavioral intervention for health promotion and Adherence rate (MARS-5), All-cause mortality, Cardiovascular events, and 3 more.
This study contributes evidence to
Primary intervention
SMS text messaging behavioral intervention for health promotion
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
6
Evidence pairs
143
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
SMS text messaging behavioral intervention for health promotion → Adherence rate (MARS-5)
SMS text messaging behavioral intervention for health promotion → Adherence rate (MARS-5)
Evidence profile
SMS text messaging behavioral intervention for health promotion → All-cause mortality
SMS text messaging behavioral intervention for health promotion → All-cause mortality
Evidence profile
SMS text messaging behavioral intervention for health promotion → Cardiovascular events
SMS text messaging behavioral intervention for health promotion → Cardiovascular events
Evidence profile
SMS text messaging behavioral intervention for health promotion → LDL cholesterol
SMS text messaging behavioral intervention for health promotion → LDL cholesterol
Evidence profile
SMS text messaging behavioral intervention for health promotion → Pill count adherence
SMS text messaging behavioral intervention for health promotion → Pill count adherence
Evidence profile
SMS text messaging behavioral intervention for health promotion → Total cholesterol
SMS text messaging behavioral intervention for health promotion → Total cholesterol
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and Adherence rate (MARS-5), Diabetes Self-Management Education and Support (DSMES) Programs and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Adherence rate (MARS-5)
Measures Adherence rate (MARS-5) as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in the evidence archive.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Diabetes Self-Management Education and Support (DSMES) Programs for Cardiovascular Outcomes.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
All-cause mortality
EvidenceScore™ Limited | EvidenceScore™ 37.0 | neutral | ConsensusScore™ Unclear | 1 study
Cardiovascular events
EvidenceScore™ Limited | EvidenceScore™ 37.0 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies and existing graph evidence signals.
Limitations
Diabetes Self-Management Education and Support (DSMES) Programs appears to improve Adipokine and Angiogenic Markers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Total cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 7 supporting studies and existing graph evidence signals.
Limitations
SMS text messaging behavioral intervention for health promotion appears to improve Adherence rate (MARS-5).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adherence rate (MARS-5)
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
SMS text messaging behavioral intervention for health promotion appears to improve Pill count adherence.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Pill count adherence
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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