StrongDecrease
Fasting Plasma Glucose (FPG)
Zinc supplementation → Fasting Plasma Glucose (FPG)
Zinc supplementation → Fasting Plasma Glucose (FPG)
Evidence profile
StrongDecreaseGlycemic Control
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Research Summary
Analyzed using Evidence Intelligence™
Zinc supplementation improves glycemic control in newly diagnosed T2DM patients
Key finding
The mean FBG in the intervention group decreased by 21.52 mg/dL.
This study examined the effects of zinc supplementation on glycemic control and lipid profiles in newly diagnosed type 2 diabetes patients, finding significant reductions in fasting plasma glucose and cholesterol levels.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Some Concerns bias
Last updated July 6, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Zinc supplementation, Placebo
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Primary outcome
Fasting Plasma Glucose (FPG)
Comparator
Placebo Group
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study examined the effects of zinc supplementation on glycemic control and lipid profiles in newly diagnosed type 2 diabetes patients, finding significant reductions in fasting plasma glucose and cholesterol levels.
Clinical relevance
These findings suggest that zinc supplementation could be a beneficial adjunct therapy for managing glycemic control and lipid profiles in patients with newly diagnosed type 2 diabetes. Improved management of these parameters is crucial for reducing the risk of complications associated with diabetes, such as cardiovascular disease.
Keep in mind
The study did not assess long-term effects of zinc supplementation. Sample size and demographic diversity may limit generalizability. No significant changes were observed in HDL, VLDL, or ESR.
Published in
Journal Reference
Publication details and source links for this paper.
Alexander M, John RA, Gurpreet SC, et al. The Impact of Zinc Supplementation on Glycemic Control and Lipid Profiles in Newly Diagnosed Type 2 Diabetes Patients. Cureus. 2024;16(9):e69180. doi:10.7759/cureus.69180
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Main Effects
Fasting Plasma Glucose decreased by 21.52 mg/dL
Postprandial blood glucose decreased by 47.53 mg/dL
LDL cholesterol decreased by 25.06 mg/dL
Triglycerides decreased by 22.2 mg/dL
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Zinc supplementation and Fasting Plasma Glucose (FPG), Glucose iAUC (OGTT), HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Zinc supplementation
Primary outcomes
- Fasting Plasma Glucose (FPG)
- Glucose iAUC (OGTT)
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
6
Evidence pairs
270
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Glucose iAUC (OGTT)
Zinc supplementation → Glucose iAUC (OGTT)
Zinc supplementation → Glucose iAUC (OGTT)
Evidence profile
StrongDecreaseGlycemic Control
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StrongDecrease
HbA1c
Zinc supplementation → HbA1c
Zinc supplementation → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
Unlock full evidence details
StrongDecrease
LDL cholesterol
Zinc supplementation → LDL cholesterol
Zinc supplementation → LDL cholesterol
Evidence profile
StrongDecreaseMetabolic Health
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StrongDecrease
Total cholesterol
Zinc supplementation → Total cholesterol
Zinc supplementation → Total cholesterol
Evidence profile
StrongDecreaseMetabolic Health
Unlock full evidence details
StrongDecrease
Triglycerides
Zinc supplementation → Triglycerides
Zinc supplementation → Triglycerides
Evidence profile
StrongDecreaseMetabolic Health
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Unlock full evidence analysis
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Evidence Suggest
- Fasting Plasma Glucose reduced by 21.52 mg/dL with zinc.
- LDL cholesterol decreased by 25.06 mg/dL.
- Triglycerides lowered by 22.2 mg/dL.
Who this applies to
- Adults newly diagnosed with type 2 diabetes.
- Patients seeking adjunct therapies for glycemic control.
Keep in Mind
- Results may not apply to long-term supplementation.
- Findings are based on a specific population and may not generalize.
- Further research is needed to confirm these effects.
Between the Lines
- The study did not assess long-term effects of zinc supplementation.
- Sample size and demographic diversity may limit generalizability.
- No significant changes were observed in HDL, VLDL, or ESR.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Zinc supplementation and Fasting Glucose, Zinc supplementation and Postprandial and OGTT Glucose.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Postprandial and OGTT Glucose Evidence Hub
All studies measuring Postprandial and OGTT Glucose
1 studies
outcome_hubMeasures Postprandial and OGTT Glucose as a key outcome.
Zinc supplementation Evidence Hub
All studies on Zinc supplementation
1 studies
intervention_hubContributes to Zinc supplementation evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Zinc supplementation and Fasting Plasma Glucose (FPG)
Intervention: Zinc supplementationOutcome: Fasting Plasma Glucose (FPG)
1 results
All studies on Zinc supplementation and Glucose iAUC (OGTT)
Intervention: Zinc supplementationOutcome: Glucose iAUC (OGTT)
1 results
All studies on Zinc supplementation
Intervention: Zinc supplementation
1 results
All studies measuring Fasting Plasma Glucose (FPG)
Outcome: Fasting Plasma Glucose (FPG)
1 results
All studies measuring Glucose iAUC (OGTT)
Outcome: Glucose iAUC (OGTT)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Zinc supplementation improve fasting plasma glucose (fpg)?
Emerging Evidence
Zinc supplementation appears to improve Fasting Plasma Glucose (FPG).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Zinc supplementation improve glucose iauc (ogtt)?
Emerging Evidence
Zinc supplementation appears to improve Glucose iAUC (OGTT).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Glucose iAUC (OGTT)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Zinc supplementation improve HbA1c?
Emerging Evidence
Zinc supplementation appears to improve HbA1c.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Zinc supplementation improve ldl cholesterol?
Emerging Evidence
Zinc supplementation appears to improve LDL cholesterol.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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