Clinical evidence dossier
Semaglutide
Nonfatal stroke
Evidence signal
Authoritative evidence signal
strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 4
- Supporting studies available for review
- 4
- Randomized trials
- 4
- Reported effects
- 13
Clinical conclusion
Semaglutide does not show benefit for Nonfatal stroke in the available evidence and may be associated with worse results.
The conclusion and evidence-signal classification are distinct authoritative fields and are reproduced as published.
Observed effects
Observed study estimates; not a pooled treatment effect.
Between-group effect
Absolute change
38.2 to 51.8 %
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 0
- Magnitude-eligible effects
- 2
Consistency
Authoritative consistency classification
mixed
- Positive
- 0
- No effect
- 2
- Mixed
- 0
- Negative
- 2
Population and applicability
Structured population data were available for 4 of 4 supporting studies. 3 studies described participants with type 2 diabetes. 4 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Adults with type 2 diabetes.
- Patients at risk for cardiovascular events.
- Adults diagnosed with type 2 diabetes.
- Adults with overweight or obesity.
- Individuals with established cardiovascular disease without diabetes.
- Adults aged 18 and older with type 2 diabetes.
- Individuals at risk for cardiovascular events.
Limitations
- Upstream consistency scoring indicates mixed findings across the evidence.
- 1 supporting study does not have a displayable topic-matched quantitative effect.
- 2 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.