Clinical evidence dossier
Very-low-calorie ketogenic diet
Body weight
Evidence signal
Authoritative evidence signal
strong
This is an authoritative evidence signal supplied by Clinical Reference. It is not a formal clinical grade, treatment recommendation, or pooled effect estimate.
Evidence snapshot
- Authoritative support records
- 3
- Supporting studies available for review
- 3
- Randomized trials
- 1
- Reported effects
- 5
Clinical conclusion
Very-low-calorie ketogenic diet shows a strong positive evidence signal for improving Body weight across the studied comparisons.
Observed effects
Observed study estimates; not a pooled treatment effect.
Change from baseline
Absolute change
-3.5 to -3.5 %
Evidence composition
- Non-randomized studies
- 0
- Other designs
- 0
- Unresolved designs
- 2
- Magnitude-eligible effects
- 1
Consistency
Authoritative consistency classification
consistent
- Positive
- 3
- No effect
- 0
- Mixed
- 0
- Negative
- 0
Population and applicability
Structured population data were available for 3 of 3 supporting studies. 3 studies described participants with type 2 diabetes. 2 studies described adult participants.
This population information refers to the materialized supporting studies available for review. Omitted support records remain part of the authoritative support accounting and are available through the audit experience.
View reported population descriptions
These descriptions are reported across the supporting studies; they are not a single synthesized population.
- Obese individuals aged 18 and older.
- Individuals diagnosed with prediabetes or early onset type 2 diabetes.
- Adults with type 2 diabetes
- Individuals seeking dietary interventions for metabolic control
- Adults newly diagnosed with type 2 diabetes.
- Patients seeking dietary interventions for diabetes management.
Limitations
- 2 relevant studies have unresolved authoritative design evidence and do not contribute to design-specific or RoB-specific claims.
- Evidence uses heterogeneous comparison contexts: baseline_within_group, usual_care.
- 2 supporting studies have high, serious, critical, unclear, or unavailable risk-of-bias information.
- 2 of 3 studies with duration data have follow-up of 12 weeks or less.
Supporting evidence
Inspect the authoritative studies and omitted support records for this dossier.