Metabolic Health

Evidence Snapshot

Evidence relationships

Studies reviewed

Interventions evaluated

Strongest evidence area

Pioglitazone

Top Evidence Areas

Rank	Intervention	Outcome	Effectiveness	Strength	Consistency	Studies
#1	Behavioral lifestyle interventions	Beta Cell function	Moderate Positive	Limited	Unclear	1
#2	Behavioral lifestyle interventions	Fasting insulin levels	Moderate Positive	Limited	Unclear	1
#3	Behavioral lifestyle interventions	Insulin resistance	Moderate Positive	Limited	Unclear	1
#4	Aerobic exercise	GLP 1	Moderate Positive	Limited	Unclear	1
#5	Aerobic exercise	MicroRNA 192	Moderate Positive	Limited	Unclear	1
#6	Aerobic exercise	VO2 max	Moderate Positive	Limited	Unclear	1
#7	Akkermansia muciniphila	Gut microbiota diversity	Moderate Positive	Limited	Consistent	1
#8	Allium hookeri extract	Fasting insulin levels	Neutral	Weak	Unclear	1
#9	Allium hookeri extract	HDL cholesterol	Neutral	Weak	Unclear	1
#10	Allium hookeri extract	LDL cholesterol	Neutral	Weak	Unclear	1

Rank #1

Beta Cell function

Behavioral lifestyle interventions

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #2

Fasting insulin levels

Behavioral lifestyle interventions

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #3

Insulin resistance

Behavioral lifestyle interventions

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #4

GLP 1

Aerobic exercise

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #5

MicroRNA 192

Aerobic exercise

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #6

VO2 max

Aerobic exercise

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Rank #7

Gut microbiota diversity

Akkermansia muciniphila

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Consistent

Studies

Rank #8

Fasting insulin levels

Allium hookeri extract

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Rank #9

HDL cholesterol

Allium hookeri extract

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Rank #10

LDL cholesterol

Allium hookeri extract

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Practical Questions

Which interventions are most often studied for Metabolic Health?

most studied

Based on 17 evidence relationships across 18 studies

Outcomes:

Fasting insulin levelsHDL cholesterolLDL cholesterolTotal cholesterolTriglycerides+7 more

Interventions:

Allium hookeri extractMultidisciplinary lifestyle intervention for type 2 diabetes remissionPioglitazone

Where are results mixed or inconsistent for Metabolic Health?

consistency issues

Based on 2 evidence relationships across 4 studies

Outcomes:

Diastolic blood pressureFasting insulin levels

Interventions:

Exercise therapyMultidisciplinary lifestyle intervention for type 2 diabetes remission

Which interventions need more research for Metabolic Health?

research gaps

Based on 3 evidence relationships across 6 studies

Outcomes:

Diastolic blood pressureSystolic blood pressureFasting insulin levels

Interventions:

Exercise therapyMultidisciplinary lifestyle intervention for type 2 diabetes remission

How does Pioglitazone compare with Tirzepatide for Metabolic Health?

compare

Based on 2 evidence relationships across 2 studies

Outcomes:

TriglyceridesTotal cholesterol

Interventions:

PioglitazoneTirzepatide

Evidence Landscape

Evidence landscape

Each bubble represents an evidence relationship. Position shows effectiveness and strength; size reflects study volume.

Limited evidence

Promising

Reliable

High impact

Lower Evidence Strength→Higher Evidence Strength

Lower Effectiveness→Higher Effectiveness

Explore by Intervention

Intervention	Pairs	Research	Avg Strength
Probiotics	4	3	46
Exercise therapy	2	2	48
Multidisciplinary lifestyle intervention for type 2 diabetes remission	6	2	42
Pioglitazone	6	2	46
Aerobic exercise	3	1	44
Akkermansia muciniphila	1	1	45
Allium hookeri extract	5	1	33
American ginseng	1	1	50
Basal insulin	1	1	47
Behavioral lifestyle interventions	3	1	45
Dapagliflozin plus linagliptin combination therapy	3	1	40
Del Immune V Extra bacterial lysate	2	1	38
Digital physician Pharmacist collaborative care	5	1	47
GLP 1 receptor agonists	1	1	47
High Intensity interval training (HIIT)	1	1	33
Integrated multidisciplinary diabetes and kidney care program	5	1	38
Mediterranean ketogenic diet	5	1	41
Resistance training	4	1	44
Systemic steroid therapy	1	1	29
Telemonitoring	2	1	46
Teplizumab	1	1	39
Tirzepatide	1	1	53
Ursodeoxycholic acid (UDCA)	3	1	42
Very Low Calorie ketogenic diet	5	1	41

Latest Research

Dapagliflozin plus linagliptin may improve time in range in T2D

Study Type: cohortPublished: 30 de mayo de 2026

int-dapagliflozin-linagliptin-combination

out-liver-to-spleen-attenuation-ratioout-systolic-blood-pressure

L. rhamnosus bacterial lysate may improve HbA1c in type 2 diabetes

Study Type: randomized-controlled-trials-rctsPublished: 30 de mayo de 2026

int-del-immune-v-extra-bacterial-lysate

out-beta-cell-functionout-insulin-sensitivity

Elderly patient with long-standing diabetes achieved sustained insulin independence through lifestyle intervention

Study Type: non-randomized-clinical-trial-non-rctPublished: 29 de mayo de 2026

int-multidisciplinary-lifestyle-intervention-for-type-2-diabetes

out-c-reactive-proteinout-fasting-insulin-levels

Intensive lifestyle program was linked to diabetes remission in Indian adults

Study Type: non-randomized-clinical-trial-non-rctPublished: 29 de mayo de 2026

int-multidisciplinary-lifestyle-intervention-for-type-2-diabetes

out-fasting-insulin-levelsout-insulin-resistance

Team-based diabetes care may improve blood sugar, blood pressure, and albuminuria

Study Type: non-randomized-clinical-trial-non-rctPublished: 29 de mayo de 2026

int-integrated-multidisciplinary-diabetes-kidney-care

out-diastolic-blood-pressureout-hdl-cholesterol

Digital pharmacist-physician care improves HbA1c in type 2 diabetes

Study Type: randomized-controlled-trials-rctsPublished: 29 de mayo de 2026

int-digital-physician-pharmacist-collaborative-care

out-10-year-ascvd-riskout-diastolic-blood-pressure

Mediterranean ketogenic eating matched VLCKD for weight loss over 3 months

Study Type: non-randomized-clinical-trial-non-rctPublished: 27 de mayo de 2026

int-mediterranean-ketogenic-dietint-very-low-calorie-ketogenic-diet

out-hdl-cholesterolout-insulin-resistance

Gut microbiota interventions may improve glucose and cardiometabolic markers in type 2 diabetes

Study Type: systematic-reviewPublished: 26 de mayo de 2026

int-probiotics

out-insulin-resistanceout-ldl-cholesterol

Natural products may improve blood sugar and cardiovascular risk markers in type 2 diabetes

Study Type: systematic-reviewPublished: 26 de mayo de 2026

int-american-ginseng

out-systolic-blood-pressure

Lifestyle changes plus probiotic use were linked with better HbA1c in one man with type 2 diabetes

Study Type: non-randomized-clinical-trial-non-rctPublished: 26 de mayo de 2026

int-probiotics

out-triglycerides

Full Evidence Table

Showing 71 of 71 evidence pairs

Intervention	Outcome	Effectiveness	Strength	Consistency	Studies
Behavioral lifestyle interventions	Beta Cell function	Moderate Positive	Limited	Unclear	1
Behavioral lifestyle interventions	Fasting insulin levels	Moderate Positive	Limited	Unclear	1
Behavioral lifestyle interventions	Insulin resistance	Moderate Positive	Limited	Unclear	1
Aerobic exercise	GLP 1	Moderate Positive	Limited	Unclear	1
Aerobic exercise	MicroRNA 192	Moderate Positive	Limited	Unclear	1
Aerobic exercise	VO2 max	Moderate Positive	Limited	Unclear	1
Akkermansia muciniphila	Gut microbiota diversity	Moderate Positive	Limited	Consistent	1
Allium hookeri extract	Fasting insulin levels	Neutral	Weak	Unclear	1
Allium hookeri extract	HDL cholesterol	Neutral	Weak	Unclear	1
Allium hookeri extract	LDL cholesterol	Neutral	Weak	Unclear	1
Allium hookeri extract	Total cholesterol	Neutral	Weak	Unclear	1
Allium hookeri extract	Triglycerides	Neutral	Weak	Unclear	1
American ginseng	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Basal insulin	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Dapagliflozin plus linagliptin combination therapy	Liver To Spleen attenuation ratio	Moderate Positive	Limited	Unclear	1
Dapagliflozin plus linagliptin combination therapy	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Dapagliflozin plus linagliptin combination therapy	Triglycerides	Moderate Positive	Limited	Unclear	1
Del Immune V Extra bacterial lysate	Beta Cell function	Neutral	Weak	Unclear	1
Del Immune V Extra bacterial lysate	Insulin sensitivity	Moderate Positive	Limited	Unclear	1
Digital physician Pharmacist collaborative care	10 Year ASCVD risk	Moderate Positive	Limited	Unclear	1
Digital physician Pharmacist collaborative care	Diastolic blood pressure	Moderate Positive	Limited	Unclear	1
Digital physician Pharmacist collaborative care	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Digital physician Pharmacist collaborative care	Total cholesterol	Moderate Positive	Limited	Unclear	1
Digital physician Pharmacist collaborative care	Triglycerides	Moderate Positive	Limited	Unclear	1
Exercise therapy	Diastolic blood pressure	Weak Positive	Limited	Mixed	2
Exercise therapy	Systolic blood pressure	Moderate Positive	Limited	Consistent	2
GLP 1 receptor agonists	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
High Intensity interval training (HIIT)	Blood lactate	Neutral	Weak	Unclear	1
Integrated multidisciplinary diabetes and kidney care program	Diastolic blood pressure	Moderate Positive	Limited	Unclear	1
Integrated multidisciplinary diabetes and kidney care program	HDL cholesterol	Moderate Negative	Weak	Unclear	1
Integrated multidisciplinary diabetes and kidney care program	LDL cholesterol	Moderate Positive	Limited	Unclear	1
Integrated multidisciplinary diabetes and kidney care program	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Integrated multidisciplinary diabetes and kidney care program	Total cholesterol	Moderate Positive	Limited	Unclear	1
Mediterranean ketogenic diet	HDL cholesterol	Neutral	Weak	Unclear	1
Mediterranean ketogenic diet	Insulin resistance	Moderate Positive	Limited	Unclear	1
Mediterranean ketogenic diet	LDL cholesterol	Moderate Positive	Limited	Unclear	1
Mediterranean ketogenic diet	Total cholesterol	Moderate Positive	Limited	Unclear	1
Mediterranean ketogenic diet	Triglycerides	Moderate Positive	Limited	Unclear	1
Multidisciplinary lifestyle intervention for type 2 diabetes remission	C Reactive protein	Moderate Positive	Limited	Unclear	1
Multidisciplinary lifestyle intervention for type 2 diabetes remission	Fasting insulin levels	Weak Positive	Limited	Mixed	2
Multidisciplinary lifestyle intervention for type 2 diabetes remission	HDL cholesterol	Moderate Positive	Limited	Unclear	1
Multidisciplinary lifestyle intervention for type 2 diabetes remission	Insulin resistance	Moderate Positive	Limited	Unclear	1
Multidisciplinary lifestyle intervention for type 2 diabetes remission	Insulin sensitivity	Moderate Positive	Limited	Unclear	1
Multidisciplinary lifestyle intervention for type 2 diabetes remission	Triglycerides	Moderate Positive	Limited	Unclear	1
Pioglitazone	Adipose tissue elastin content	Moderate Positive	Limited	Unclear	1
Pioglitazone	Adipose tissue macrophage count	Moderate Positive	Limited	Unclear	1
Pioglitazone	Adipose tissue mast cell count	Moderate Positive	Limited	Unclear	1
Pioglitazone	Capillary density	Moderate Positive	Limited	Unclear	1
Pioglitazone	Insulin sensitivity	Moderate Positive	Limited	Unclear	1
Pioglitazone	Triglycerides	Moderate Positive	Limited	Unclear	1
Probiotics	Gut microbiota diversity	Moderate Positive	Limited	Unclear	1
Probiotics	Insulin resistance	Moderate Positive	Limited	Consistent	2
Probiotics	LDL cholesterol	Moderate Positive	Limited	Unclear	1
Probiotics	Triglycerides	Moderate Positive	Limited	Consistent	2
Resistance training	Fasting insulin levels	Moderate Positive	Limited	Unclear	1
Resistance training	GLP 1	Moderate Positive	Limited	Unclear	1
Resistance training	MicroRNA 192	Moderate Positive	Limited	Unclear	1
Resistance training	VO2 max	Moderate Positive	Limited	Unclear	1
Systemic steroid therapy	Beta Cell function	Neutral	Weak	Unclear	1
Telemonitoring	Diastolic blood pressure	Moderate Positive	Limited	Unclear	1
Telemonitoring	Systolic blood pressure	Moderate Positive	Limited	Unclear	1
Teplizumab	Beta Cell function	Moderate Positive	Weak	Unclear	1
Tirzepatide	Total cholesterol	Moderate Positive	Limited	Unclear	1
Ursodeoxycholic acid (UDCA)	Left atrial contractile strain (echocardiography)	Moderate Positive	Limited	Unclear	1
Ursodeoxycholic acid (UDCA)	Left atrial reservoir strain (echocardiography)	Moderate Positive	Limited	Unclear	1
Ursodeoxycholic acid (UDCA)	Left ventricular ejection fraction (LVEF)	Neutral	Weak	Unclear	1
Very Low Calorie ketogenic diet	HDL cholesterol	Neutral	Weak	Unclear	1
Very Low Calorie ketogenic diet	Insulin resistance	Moderate Positive	Limited	Unclear	1
Very Low Calorie ketogenic diet	LDL cholesterol	Moderate Positive	Limited	Unclear	1
Very Low Calorie ketogenic diet	Total cholesterol	Moderate Positive	Limited	Unclear	1
Very Low Calorie ketogenic diet	Triglycerides	Moderate Positive	Limited	Unclear	1

Intervention → Outcome

Behavioral lifestyle interventions → Beta Cell function

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Behavioral lifestyle interventions → Fasting insulin levels

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Behavioral lifestyle interventions → Insulin resistance

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Aerobic exercise → GLP 1

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Aerobic exercise → MicroRNA 192

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Aerobic exercise → VO2 max

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Akkermansia muciniphila → Gut microbiota diversity

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Consistent

Studies

Intervention → Outcome

Allium hookeri extract → Fasting insulin levels

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Allium hookeri extract → HDL cholesterol

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Allium hookeri extract → LDL cholesterol

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Allium hookeri extract → Total cholesterol

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Allium hookeri extract → Triglycerides

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

American ginseng → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Basal insulin → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Dapagliflozin plus linagliptin combination therapy → Liver To Spleen attenuation ratio

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Dapagliflozin plus linagliptin combination therapy → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Dapagliflozin plus linagliptin combination therapy → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Del Immune V Extra bacterial lysate → Beta Cell function

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Del Immune V Extra bacterial lysate → Insulin sensitivity

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Digital physician Pharmacist collaborative care → 10 Year ASCVD risk

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Digital physician Pharmacist collaborative care → Diastolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Digital physician Pharmacist collaborative care → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Digital physician Pharmacist collaborative care → Total cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Digital physician Pharmacist collaborative care → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Exercise therapy → Diastolic blood pressure

Effectiveness

Weak Positive

Strength

Limited

Consistency

Mixed

Studies

Intervention → Outcome

Exercise therapy → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Consistent

Studies

Intervention → Outcome

GLP 1 receptor agonists → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

High Intensity interval training (HIIT) → Blood lactate

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Integrated multidisciplinary diabetes and kidney care program → Diastolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Integrated multidisciplinary diabetes and kidney care program → HDL cholesterol

Effectiveness

Moderate Negative

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Integrated multidisciplinary diabetes and kidney care program → LDL cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Integrated multidisciplinary diabetes and kidney care program → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Integrated multidisciplinary diabetes and kidney care program → Total cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Mediterranean ketogenic diet → HDL cholesterol

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Mediterranean ketogenic diet → Insulin resistance

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Mediterranean ketogenic diet → LDL cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Mediterranean ketogenic diet → Total cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Mediterranean ketogenic diet → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → C Reactive protein

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → Fasting insulin levels

Effectiveness

Weak Positive

Strength

Limited

Consistency

Mixed

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → HDL cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → Insulin resistance

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → Insulin sensitivity

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Multidisciplinary lifestyle intervention for type 2 diabetes remission → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Adipose tissue elastin content

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Adipose tissue macrophage count

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Adipose tissue mast cell count

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Capillary density

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Insulin sensitivity

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Pioglitazone → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Probiotics → Gut microbiota diversity

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Probiotics → Insulin resistance

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Consistent

Studies

Intervention → Outcome

Probiotics → LDL cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Probiotics → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Consistent

Studies

Intervention → Outcome

Resistance training → Fasting insulin levels

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Resistance training → GLP 1

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Resistance training → MicroRNA 192

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Resistance training → VO2 max

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Systemic steroid therapy → Beta Cell function

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Telemonitoring → Diastolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Telemonitoring → Systolic blood pressure

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Teplizumab → Beta Cell function

Effectiveness

Moderate Positive

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Tirzepatide → Total cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Ursodeoxycholic acid (UDCA) → Left atrial contractile strain (echocardiography)

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Ursodeoxycholic acid (UDCA) → Left atrial reservoir strain (echocardiography)

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Ursodeoxycholic acid (UDCA) → Left ventricular ejection fraction (LVEF)

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Very Low Calorie ketogenic diet → HDL cholesterol

Effectiveness

Neutral

Strength

Weak

Consistency

Unclear

Studies

Intervention → Outcome

Very Low Calorie ketogenic diet → Insulin resistance

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Very Low Calorie ketogenic diet → LDL cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Very Low Calorie ketogenic diet → Total cholesterol

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies

Intervention → Outcome

Very Low Calorie ketogenic diet → Triglycerides

Effectiveness

Moderate Positive

Strength

Limited

Consistency

Unclear

Studies