Evidence Question

Do SGLT2 inhibitors lower All-cause mortality?

Related to: Cardiometabolic Risk

Short answer

SGLT2 inhibitors may lower All-cause mortality.

How the evidence connects

Each connection shows the published evidence classification for that intervention and outcome relationship.

Intervention

SGLT2 inhibitors

Intervention

Moderate
Positive
Mixed

2 studies · 2 RCTs

Outcome

All-cause mortality

Outcome

Why do we say this?

Some supporting studies report the observed direction, while others do not show the same pattern.

Explore the evidence