Última actualización 29 de agosto de 2026
Key finding
10 kHz SCS reduced pain by a mean of 79.9% compared to baseline.
High-frequency (10 kHz) spinal cord stimulation added to conventional medical management in patients with painful diabetic neuropathy.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
High-frequency (10 kHz) spinal cord stimulation added to conventional medical management in patients with painful diabetic neuropathy.
This study evaluated High-frequency (10 kHz) spinal cord stimulation added to conventional medical management in patients with painful diabetic neuropathy.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Erika AP, Thomas GS, James AS, et al. Long-term Efficacy of High-Frequency Spinal Cord Stimulation for Treating Refractory Painful Diabetic Neuropathy: Results from the SENZA-PDN Study. Diabetes research and clinical practice. 2023;203:110865-110865. doi:10.1016/j.diabres.2023.110865
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to 10 kHz Spinal Cord Stimulation (SCS), Standard treatment and Clinically Meaningful Neurological Improvement, Health-related quality of life, Pain Intensity Score, and 1 more.
This study contributes evidence to
Primary intervention
10 kHz Spinal Cord Stimulation (SCS)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
5
Evidence pairs
105
Related studies
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Core evidence
The primary outcomes reported in this study.
10 kHz Spinal Cord Stimulation (SCS) → Clinically Meaningful Neurological Improvement
10 kHz Spinal Cord Stimulation (SCS) → Clinically Meaningful Neurological Improvement
10 kHz Spinal Cord Stimulation (SCS) → Health-related quality of life
10 kHz Spinal Cord Stimulation (SCS) → Health-related quality of life
10 kHz Spinal Cord Stimulation (SCS) → Pain Intensity Score
10 kHz Spinal Cord Stimulation (SCS) → Pain Intensity Score
10 kHz Spinal Cord Stimulation (SCS) → Sleep quality
10 kHz Spinal Cord Stimulation (SCS) → Sleep quality
Standard treatment → Pain Intensity Score
Standard treatment → Pain Intensity Score
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on 10 kHz Spinal Cord Stimulation (SCS) and Pain Intensity Score, 10 kHz Spinal Cord Stimulation (SCS) and Quality of Life Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies on 10 kHz Spinal Cord Stimulation (SCS)
Contributes to 10 kHz Spinal Cord Stimulation (SCS) evidence base.
All studies measuring Pain Intensity Score
Measures Pain Intensity Score as a key outcome.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
10 kHz Spinal Cord Stimulation (SCS) appears to improve Pain Intensity Score.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Pain Intensity Score
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
10 kHz Spinal Cord Stimulation (SCS) appears to improve Clinically Meaningful Neurological Improvement.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinically Meaningful Neurological Improvement
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
10 kHz Spinal Cord Stimulation (SCS) appears to improve Health-related quality of life.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Health-related quality of life
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Standard treatment for Pain Intensity Score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Pain Intensity Score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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