Última actualización 29 de agosto de 2026
Key finding
Mean serum 25(OH)D concentration increased from 48 to 95 nmol/L in the treatment group.
Combined vitamin D and calcium supplementation in adults at risk for type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Combined vitamin D and calcium supplementation in adults at risk for type 2 diabetes.
This study evaluated Combined vitamin D and calcium supplementation in adults at risk for type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Claudia G, Robin MD, André C, et al. Daily calcium and vitamin D supplementation may improve insulin sensitivity in adults with prediabetes. PLoS ONE. 2014;9(10):e109607. doi:10.1371/journal.pone.0109607
Evidence network
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This study contributes evidence to Calcium carbonate and cholecalciferol supplementation and Body weight, C-reactive protein, Change in insulinogenic index from baseline to week 12, and 12 more.
This study contributes evidence to
Primary intervention
Calcium carbonate and cholecalciferol supplementation
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
15
Evidence pairs
565
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
Calcium carbonate and cholecalciferol supplementation → Body weight
Calcium carbonate and cholecalciferol supplementation → Body weight
Calcium carbonate and cholecalciferol supplementation → C-reactive protein
Calcium carbonate and cholecalciferol supplementation → C-reactive protein
Calcium carbonate and cholecalciferol supplementation → Change in insulinogenic index from baseline to week 12
Calcium carbonate and cholecalciferol supplementation → Change in insulinogenic index from baseline to week 12
Calcium carbonate and cholecalciferol supplementation → Diastolic blood pressure
Calcium carbonate and cholecalciferol supplementation → Diastolic blood pressure
Calcium carbonate and cholecalciferol supplementation → High-density lipoprotein
Calcium carbonate and cholecalciferol supplementation → High-density lipoprotein
Calcium carbonate and cholecalciferol supplementation → Insulin sensitivity
Calcium carbonate and cholecalciferol supplementation → Insulin sensitivity
Calcium carbonate and cholecalciferol supplementation → Interleukin-6 (IL-6)
Calcium carbonate and cholecalciferol supplementation → Interleukin-6 (IL-6)
Calcium carbonate and cholecalciferol supplementation → Low-density lipoprotein
Calcium carbonate and cholecalciferol supplementation → Low-density lipoprotein
Calcium carbonate and cholecalciferol supplementation → Matsuda index improvement
Calcium carbonate and cholecalciferol supplementation → Matsuda index improvement
Calcium carbonate and cholecalciferol supplementation → Serum 25-hydroxyvitamin D
Calcium carbonate and cholecalciferol supplementation → Serum 25-hydroxyvitamin D
Calcium carbonate and cholecalciferol supplementation → Systolic blood pressure
Calcium carbonate and cholecalciferol supplementation → Systolic blood pressure
Calcium carbonate and cholecalciferol supplementation → Total cholesterol
Calcium carbonate and cholecalciferol supplementation → Total cholesterol
Calcium carbonate and cholecalciferol supplementation → Triglycerides
Calcium carbonate and cholecalciferol supplementation → Triglycerides
Calcium carbonate and cholecalciferol supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Calcium carbonate and cholecalciferol supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Calcium carbonate and cholecalciferol supplementation → Waist circumference
Calcium carbonate and cholecalciferol supplementation → Waist circumference
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Calcium carbonate and cholecalciferol supplementation and Body Weight, Calcium carbonate and cholecalciferol supplementation and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on Calcium carbonate and cholecalciferol supplementation
Contributes to Calcium carbonate and cholecalciferol supplementation evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Calcium carbonate and cholecalciferol supplementation appears to improve Serum 25-hydroxyvitamin D.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum 25-hydroxyvitamin D
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Calcium carbonate and cholecalciferol supplementation for Body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Calcium carbonate and cholecalciferol supplementation for C-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Calcium carbonate and cholecalciferol supplementation for Change in insulinogenic index from baseline to week 12.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in insulinogenic index from baseline to week 12
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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