Última actualización 3 de julio de 2026
Key finding
FMD increased from 4.3% to 5.6% in the fasted state (p < 0.01).
L-Citrulline supplementation added to standard treatment in adults with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
L-Citrulline supplementation added to standard treatment in adults with type 2 diabetes.
This study evaluated L-Citrulline supplementation added to standard treatment in adults with type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Yejin K, Katherine ND, Danielle EL, Arturo F, Iván CR, Alicia S. Citrulline Supplementation Improves Vascular Function and Glycemic Control in Adults with Type 2 Diabetes. Nutrients. 2025;17(23):3739. doi:10.3390/nu17233739
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to L-citrulline supplementation (Phase 1) and Blood glucose, Brachial artery flow-mediated dilation (FMD), Femoral-ankle pulse wave velocity (faPWV), and 2 more.
This study contributes evidence to
Primary intervention
L-citrulline supplementation (Phase 1)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
5
Evidence pairs
292
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Evidencia relacionada
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
L-citrulline supplementation (Phase 1) → Blood glucose
L-citrulline supplementation (Phase 1) → Blood glucose
L-citrulline supplementation (Phase 1) → Brachial artery flow-mediated dilation (FMD)
L-citrulline supplementation (Phase 1) → Brachial artery flow-mediated dilation (FMD)
L-citrulline supplementation (Phase 1) → Femoral-ankle pulse wave velocity (faPWV)
L-citrulline supplementation (Phase 1) → Femoral-ankle pulse wave velocity (faPWV)
L-citrulline supplementation (Phase 1) → Femoral-ankle pulse wave velocity (faPWV) during acute hyperglycemia
L-citrulline supplementation (Phase 1) → Femoral-ankle pulse wave velocity (faPWV) during acute hyperglycemia
L-citrulline supplementation (Phase 1) → Systolic blood pressure
L-citrulline supplementation (Phase 1) → Systolic blood pressure
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on L-citrulline supplementation (Phase 1) and Fasting Glucose, L-citrulline supplementation (Phase 1) and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on L-citrulline supplementation (Phase 1)
Contributes to L-citrulline supplementation (Phase 1) evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
L-citrulline supplementation (Phase 1) appears to improve Blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
L-citrulline supplementation (Phase 1) appears to improve Brachial artery flow-mediated dilation (FMD).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Brachial artery flow-mediated dilation (FMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
L-citrulline supplementation (Phase 1) appears to improve Femoral-ankle pulse wave velocity (faPWV).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Femoral-ankle pulse wave velocity (faPWV)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
L-citrulline supplementation (Phase 1) appears to improve Femoral-ankle pulse wave velocity (faPWV) during acute hyperglycemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Femoral-ankle pulse wave velocity (faPWV) during acute hyperglycemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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