Resumen de Investigación

Curcumin-Piperine Improves Mental Health and Sleep in Diabetic Retinopathy

Moderate confidence
Low bias
Última actualización 19 de junio de 2026

Conclusión Clave:

The study evaluated the effects of a curcumin-piperine combination on mental health and physical factors in diabetic retinopathy patients, showing significant improvements in various outcomes.

Estudio de un Vistazo

Qué se estudió

Curcumin-piperine combination on mental health status and anthropometric indices in patients with diabetic retinopathy.

Participantes

Young Adult (19–39), Middle Aged (40-64)

Male, Female

with T2 Diabetes

Intervención

Curcumin-piperine combination, Placebo

Resultados

Quality of sleep, Depression, Anxiety, Stress, Body Mass Index (BMI), Waist Circumference (WC), Quality of sleep (Placebo), Depression (Placebo), Anxiety (Placebo), Stress (Placebo), Body Mass Index (BMI) (Placebo), Waist Circumference (WC) (Placebo)

Financiamiento

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Efectos Principales

Quality of sleep improved, decreasing by 0.91 ± 1.28 (p=0.025)

Depression decreased by 1.61 ± 2.23 (p=0.001)

Anxiety decreased by 1.31 ± 2.23 (p=0.005)

Body Mass Index (BMI) decreased by 0.08 ± 0.15 (p=0.003)

Resumen de Evidencia

InterventionOutcomeMeasured ChangeStudy Effect
Supplements
Curcumin plus piperine
(Supplements)
Patient-Reported
Anxiety score
(Patient-Reported)
Decrease
Strong
Supplements
Curcumin plus piperine
(Supplements)
Weight & Anthropometrics
BMI
(Weight & Anthropometrics)
Decrease
Strong
Supplements
Curcumin plus piperine
(Supplements)
Patient-Reported
Depression score
(Patient-Reported)
Decrease
Strong
Supplements
Curcumin plus piperine
(Supplements)
Patient-Reported
Sleep quality
(Patient-Reported)
Decrease
Strong
Supplements
Curcumin plus piperine
(Supplements)
Patient-Reported
Stress score
(Patient-Reported)
Decrease
Strong
Supplements
Curcumin plus piperine
(Supplements)
Weight & Anthropometrics
Waist circumference
(Weight & Anthropometrics)
Decrease
Strong
Medications
Placebo
(Medications)
Patient-Reported
Anxiety (Placebo)
(Patient-Reported)
No Change
Unclear
Medications
Placebo
(Medications)
Weight & Anthropometrics
BMI
(Weight & Anthropometrics)
No Change
Unclear
Medications
Placebo
(Medications)
Patient-Reported
Depression (Placebo)
(Patient-Reported)
No Change
Unclear
Medications
Placebo
(Medications)
Patient-Reported
Sleep quality
(Patient-Reported)
No Change
Unclear
Medications
Placebo
(Medications)
Patient-Reported
Stress (Placebo)
(Patient-Reported)
No Change
Unclear
Medications
Placebo
(Medications)
Weight & Anthropometrics
Waist circumference
(Weight & Anthropometrics)
No Change
Unclear

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evidence suggest

La Evidencia Sugiere

  • Quality of sleep improved significantly with a decrease of 0.91 points.
  • Depression levels decreased significantly by 1.61 points.
  • Anxiety levels decreased significantly by 1.31 points.
who this applies

A quién se aplica

  • Adults diagnosed with diabetic retinopathy
  • Patients experiencing mental health issues such as depression and anxiety
keep in mind

Tener en Cuenta

  • Results may not be applicable to all diabetic retinopathy patients.
  • Further research is needed to confirm long-term effects.
  • The study did not assess other potential confounding factors.
between the lines

Entre Líneas

  • Limited sample size may affect generalizability
  • Short duration of the study may not capture long-term effects
  • Potential for unmeasured confounders impacting results

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Referencia de la Revista

Sepide A, Alireza D, Amirhossein S, et al. The Effect of Curcumin-Piperine Combination on Mental Health and Anthropometric Indices in Patients with Diabetic Retinopathy: A Randomized Controlled Trial. International Journal of Preventive Medicine. 2026;17:14. doi:10.4103/ijpvm.ijpvm_276_23

View DOIView on PubMedView on PMC

Connected Evidence

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This study contributes to evidence on Botanical Supplements and Mental Health, Botanical Supplements and Body Weight.

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This study contributes to the evidence on the following intervention–outcome relationships.

Preguntas que esta evidencia ayuda a responder

Key clinical and research questions this study contributes to.

Does curcumin plus piperine improve Anxiety score?

Based on connected evidence for Curcumin plus piperine and Anxiety score.

Does curcumin plus piperine affect BMI in people with diabetes?

Exploring evidence on Curcumin plus piperine and BMI outcomes.

What does the evidence say about curcumin plus piperine and Sleep quality?

Review of studies examining Curcumin plus piperine and Sleep quality.

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