Última actualización 6 de julio de 2026
Key finding
Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)
The study evaluated the effects of curcumin-piperine supplementation on oxidative stress and kidney function in diabetic retinopathy patients, finding significant improvements in antioxidant capacity and creatinine levels.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
The study evaluated the effects of curcumin-piperine supplementation on oxidative stress and kidney function in diabetic retinopathy patients, finding significant improvements in antioxidant capacity and creatinine levels.
These findings are significant as they highlight a potential therapeutic role for curcumin-piperine in reducing oxidative stress and improving kidney function in patients with diabetic retinopathy. Given the increasing prevalence of diabetes and its complications, such as retinopathy, identifying effective dietary supplements could enhance patient care and outcomes.
Limited sample size may affect generalizability. Short duration of the intervention might not capture long-term effects. No significant effects observed on several other health markers.
Published in
Publication details and source links for this paper.
Sepide A, Alireza D, Amirhossein S, et al. Curcumin-Piperine Supplementation Improves Oxidative Stress and Reduces Creatinine in Diabetic Retinopathy. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2024;29:64. doi:10.4103/jrms.jrms_174_24
Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)
Curcumin-piperine significantly increased superoxide dismutase levels (0.77 ± 2.11 vs. -0.45 ± 3.08; P = 0.031)
Curcumin-piperine decreased serum creatinine levels (-0.04 ± 0.16 vs. 0.03 ± 0.05; P = 0.042)
Evidence network
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This study contributes evidence to Curcumin plus piperine and Blood urea nitrogen (BUN), C-reactive protein, Fasting Plasma Glucose (FPG), and 7 more.
This study contributes evidence to
Primary intervention
Curcumin plus piperine
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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10
Evidence pairs
390
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Core evidence
The primary outcomes reported in this study.
Curcumin plus piperine → Blood urea nitrogen (BUN)
Curcumin plus piperine → Blood urea nitrogen (BUN)
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → Fasting Plasma Glucose (FPG)
Curcumin plus piperine → Fasting Plasma Glucose (FPG)
Curcumin plus piperine → Malondialdehyde (MDA)
Curcumin plus piperine → Malondialdehyde (MDA)
Curcumin plus piperine → Optical coherence tomography
Curcumin plus piperine → Optical coherence tomography
Curcumin plus piperine → Optical coherence tomography angiography
Curcumin plus piperine → Optical coherence tomography angiography
Curcumin plus piperine → Superoxide Dismutase (SOD)
Curcumin plus piperine → Superoxide Dismutase (SOD)
Curcumin plus piperine → Total Antioxidant Capacity (TAC)
Curcumin plus piperine → Total Antioxidant Capacity (TAC)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Blood urea nitrogen (BUN), Curcumin Supplements and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Blood urea nitrogen (BUN)
Measures Blood urea nitrogen (BUN) as a key outcome.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
Curcumin Supplements may improve Inflammatory Markers.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Curcumin Supplements appears to improve Oxidative Stress Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Total Antioxidant Capacity (TAC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
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