Evidence Intelligence™
- EvidenceScore™
- 79
- Strong
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Dapagliflozin improves diabetes remission rates with calorie restriction
Última actualización 12 de septiembre de 2026
Key finding
Remission of diabetes was achieved in 44% (73/165) of patients in the dapagliflozin group and 28% (46/163) of patients in the placebo group (risk ratio 1.56, 95% CI 1.17 to 2.09; P=0.002).
This study evaluated the effectiveness of dapagliflozin combined with calorie restriction for achieving remission in type 2 diabetes. The dapagliflozin group showed a higher remission rate compared to the placebo group.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effectiveness of dapagliflozin combined with calorie restriction for achieving remission in type 2 diabetes. The dapagliflozin group showed a higher remission rate compared to the placebo group.
Clinical relevance
These findings are significant as they suggest that dapagliflozin, when used with calorie restriction, can effectively help individuals with type 2 diabetes achieve remission. This could lead to better long-term health outcomes and reduced reliance on diabetes medications, highlighting the importance of combined lifestyle and pharmacological interventions in diabetes management.
Keep in mind
The study's sample size may limit the generalizability of the findings. The change in waist circumference was not statistically significant. Long-term effects and sustainability of remission were not assessed.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Yuejun L, Ying C, Jianhua M, et al. Dapagliflozin plus calorie restriction for remission of type 2 diabetes: a multicentre, double blind, randomised, placebo controlled trial. The BMJ. 2025;388:e081820. doi:10.1136/bmj-2024-081820
Efectos Principales
Dapagliflozin group achieved a diabetes remission rate of 44% compared to 28% in the placebo group (risk ratio 1.56, p=0.002).
The dapagliflozin group experienced a significant weight loss of -1.3 kg compared to placebo (p=0.001).
Fasting plasma glucose levels decreased by -9.2 mg/dL in the dapagliflozin group, significantly more than in the placebo group.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Calorie restriction and Body fat mass, Body weight, Diabetes remission, and 6 more.
This study contributes evidence to
Primary intervention
Calorie restriction
Primary outcomes
- Body fat mass
- Body weight
- Diabetes remission
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
10
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
10
Related topics
9
Evidence pairs
3765
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 10 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Dietary Patterns
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
Insulin Resistance
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 6 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Calorie restriction → Fasting Plasma Glucose (FPG)
Calorie restriction → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 90
- Very Positive
- ConsistencyScore™
- 80
- consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerSystolic blood pressure
Calorie restriction → Systolic blood pressure
Calorie restriction → Systolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerWaist circumference
Calorie restriction → Waist circumference
Calorie restriction → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Dapagliflozin led to a 44% remission rate in diabetes compared to 28% in placebo.
- Participants on dapagliflozin lost an average of 1.3 kg more than those on placebo.
- Fasting plasma glucose levels improved significantly more in the dapagliflozin group.
A quién se aplica
- Adults diagnosed with type 2 diabetes.
- Individuals seeking weight loss and improved blood sugar control.
Tener en Cuenta
- Results may not be applicable to all populations due to sample characteristics.
- The study did not evaluate the long-term sustainability of diabetes remission.
- Participants' adherence to calorie restriction may vary, affecting outcomes.
Entre Líneas
- The study's sample size may limit the generalizability of the findings.
- The change in waist circumference was not statistically significant.
- Long-term effects and sustainability of remission were not assessed.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Calorie restriction and HbA1c, Calorie restriction and Body Weight.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Calorie restriction → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 90
- Very Positive
- ConsistencyScore™
- 80
- consistent
Estudios de apoyo: Basado en 5 estudios
View evidenceDiet and Nutrition
Calorie restriction → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 6 estudios
View evidenceDiet and Nutrition
Calorie restriction → Blood Pressure
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
6 studies
outcome_hubMeasures Body Weight as a key outcome.
Calorie restriction Evidence Hub
All studies on Calorie restriction
5 studies
intervention_hubContributes to Calorie restriction evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Blood Pressure Evidence Hub
All studies measuring Blood Pressure
2 studies
outcome_hubMeasures Blood Pressure as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Calorie restriction and HbA1c
Intervention: Calorie restrictionOutcome: HbA1c
5 results
All studies on Calorie restriction and Body weight
Intervention: Calorie restrictionOutcome: Body weight
6 results
All studies on Calorie restriction
Intervention: Calorie restriction
5 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
All studies measuring Body weight
Outcome: Body weight
6 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Calorie restriction lower HbA1c?
Strong Evidence
Calorie restriction appears to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Calorie restriction affect body weight?
Strong Evidence
Calorie restriction may affect body weight.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 82.3 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
Does Calorie restriction affect waist circumference?
Strong Evidence
Calorie restriction appears to affect waist circumference.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Waist circumference
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Calorie restriction improve body fat mass?
Strong Evidence
Calorie restriction may improve body fat mass.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Body fat mass
EvidenceScore™ Strong | EvidenceScore™ 78.5 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Evidence topics
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