Última actualización 8 de julio de 2026
Key finding
The primary end point occurred in 175 participants (35%) in the active OMVM group and 175 (35%) in the placebo group (hazard ratio [HR], 0.99 [95% CI, 0.80-1.22]; P = .92).
This study evaluated the effects of oral multivitamins and multiminerals (OMVM) in patients with diabetes and a history of myocardial infarction. The findings indicated no significant differences in major cardiovascular outcomes between the OMVM and placebo groups.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of oral multivitamins and multiminerals (OMVM) in patients with diabetes and a history of myocardial infarction. The findings indicated no significant differences in major cardiovascular outcomes between the OMVM and placebo groups.
These findings are important for clinicians treating diabetic patients with a history of myocardial infarction, as they suggest that routine supplementation with multivitamins and minerals may not provide additional cardiovascular protection. This can help guide treatment decisions and resource allocation in managing these patients.
No significant differences in outcomes may limit the perceived effectiveness of OMVM. The study population may not be generalizable to all diabetic patients. Potential unmeasured confounders could influence the results.
Published in
Publication details and source links for this paper.
Francisco U, Gervasio AL, Kevin JA, et al. Oral Multivitamins and Multiminerals in Patients with Diabetes and Prior Myocardial Infarction. JAMA Internal Medicine. 2025;185(5):540-548. doi:10.1001/jamainternmed.2024.8408
The primary composite outcome occurred in 35% of both the OMVM and placebo groups (HR, 0.99; P = .92).
Myocardial infarction incidence was 10.8% in the OMVM group versus 9.6% in the placebo group.
Stroke incidence was higher in the OMVM group (4.0%) compared to the placebo group (2.0%).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Oral multivitamins and multiminerals (OMVM) and Adverse events incidence, All-cause mortality, Composite of CV death, non-fatal myocardial infarction, or non-fatal stroke, and 3 more.
This study contributes evidence to
Primary intervention
Oral multivitamins and multiminerals (OMVM)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
47
Related studies
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
Core evidence
The primary outcomes reported in this study.
Oral multivitamins and multiminerals (OMVM) → Adverse events incidence
Oral multivitamins and multiminerals (OMVM) → Adverse events incidence
Oral multivitamins and multiminerals (OMVM) → All-cause mortality
Oral multivitamins and multiminerals (OMVM) → All-cause mortality
Oral multivitamins and multiminerals (OMVM) → Composite of CV death, non-fatal myocardial infarction, or non-fatal stroke
Oral multivitamins and multiminerals (OMVM) → Composite of CV death, non-fatal myocardial infarction, or non-fatal stroke
Oral multivitamins and multiminerals (OMVM) → Coronary revascularization
Oral multivitamins and multiminerals (OMVM) → Coronary revascularization
Oral multivitamins and multiminerals (OMVM) → Hospitalization for unstable angina
Oral multivitamins and multiminerals (OMVM) → Hospitalization for unstable angina
Oral multivitamins and multiminerals (OMVM) → Incidence of stroke
Oral multivitamins and multiminerals (OMVM) → Incidence of stroke
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Oral multivitamins and multiminerals (OMVM) and Adverse events incidence, Oral multivitamins and multiminerals (OMVM) and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies on Oral multivitamins and multiminerals (OMVM)
Contributes to Oral multivitamins and multiminerals (OMVM) evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Oral multivitamins and multiminerals (OMVM) for Adverse events incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Oral multivitamins and multiminerals (OMVM) for All-cause mortality.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
All-cause mortality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Oral multivitamins and multiminerals (OMVM) for Composite of CV death, non-fatal myocardial infarction, or non-fatal stroke.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Composite of CV death, non-fatal myocardial infarction, or non-fatal stroke
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Oral multivitamins and multiminerals (OMVM) for Coronary revascularization.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Coronary revascularization
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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