Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
High-dose vitamin D3 does not improve insulin resistance in type 2 diabetes
Última actualización 19 de junio de 2026
Key finding
Serum 25-hydroxyvitamin D concentrations increased from 14.55 ± 5.70 ng/mL to 29.28 ± 12.20 ng/mL.
This study investigated the effects of high-dose Vitamin D3 supplementation on insulin resistance and glycaemic control in adult males with type 2 diabetes. It found no significant differences in key metabolic outcomes between the intervention and placebo groups.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
Guarda investigacion, organiza estudios y vuelve a encontrar evidencia importante rapidamente.
Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of high-dose Vitamin D3 supplementation on insulin resistance and glycaemic control in adult males with type 2 diabetes. It found no significant differences in key metabolic outcomes between the intervention and placebo groups.
Clinical relevance
Understanding the role of Vitamin D3 in diabetes management is crucial, as many patients seek supplements for better metabolic health. This study suggests that high-dose Vitamin D3 may not provide the expected benefits for insulin resistance or glycaemic control, which can guide clinicians in making informed recommendations about supplementation for their patients with type 2 diabetes.
Keep in mind
The study focused only on adult males, limiting generalizability to other populations. No significant changes were observed in primary metabolic outcomes, raising questions about the intervention's effectiveness. The duration of the study may not have been sufficient to observe long-term effects.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Muhammed HN, Bassam AH, Noordin O, et al. The Effect of High-Dose Vitamin D3 Supplementation on Insulin Resistance and Glycaemic Control in Adult Males with Type 2 Diabetes: A Double-Blind, Randomised, Placebo-Controlled Clinical Trial. Journal of Pharmaceutical Policy and Practice. 2026;19(1):2680824. doi:10.1080/20523211.2026.2680824
Efectos Principales
No statistically significant difference in insulin resistance (HOMA-IR) between groups at 24 weeks.
No significant difference in fasting plasma glucose levels at 24 weeks.
Vitamin D3 supplementation significantly increased serum 25-hydroxyvitamin D concentrations by 14.73 ng/mL (p=0.00012).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and BMI, Fasting Plasma Glucose (FPG), Fasting insulin levels, and 4 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- BMI
- Fasting Plasma Glucose (FPG)
- Fasting insulin levels
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
5
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
5
Related topics
7
Evidence pairs
1295
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 5 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Agrega evidencia relacionada a tu Evidence Tracker
Guarda estudios y paginas de evidencia, organiza tu Evidence Tracker y manten en un solo lugar la investigacion que te importa.
Evidencia principal
Tema de evidencia
Insulin Resistance
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
Supplements and Nutraceuticals
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Fasting insulin levels
Vitamin D supplementation → Fasting insulin levels
Vitamin D supplementation → Fasting insulin levels
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 75
- consistent
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerInsulin resistance
Vitamin D supplementation → Insulin resistance
Vitamin D supplementation → Insulin resistance
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerSerum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Evidence Intelligence™
- EvidenceScore™
- 80
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 6 estudios
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Vitamin D3 supplementation increased serum 25-hydroxyvitamin D levels significantly.
- No significant changes were found in insulin resistance or glycaemic control.
- The study's findings suggest limited effectiveness of high-dose Vitamin D3 for diabetes management.
A quién se aplica
- Adult males diagnosed with type 2 diabetes.
- Patients seeking to manage diabetes through supplementation.
Tener en Cuenta
- Results may not apply to women or younger populations.
- The study did not measure long-term effects beyond 24 weeks.
- Further research is needed to explore different dosages or combinations with other treatments.
Entre Líneas
- The study focused only on adult males, limiting generalizability to other populations.
- No significant changes were observed in primary metabolic outcomes, raising questions about the intervention's effectiveness.
- The duration of the study may not have been sufficient to observe long-term effects.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and HbA1c, Vitamin D supplementation and Adipokine and Angiogenic Markers.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Vitamin D supplementation → HbA1c
Supplements
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- 80
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 6 estudios
View evidenceSupplements
Vitamin D supplementation → lipid profiles
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
6 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
5 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
lipid profiles Evidence Hub
All studies measuring lipid profiles
1 studies
outcome_hubMeasures lipid profiles as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Vitamin D supplementation and HbA1c
Intervention: Vitamin D supplementationOutcome: HbA1c
5 results
All studies on Vitamin D supplementation and Serum 25-hydroxyvitamin D
Intervention: Vitamin D supplementationOutcome: Serum 25-hydroxyvitamin D
6 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
5 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
All studies measuring Serum 25-hydroxyvitamin D
Outcome: Serum 25-hydroxyvitamin D
6 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve HbA1c?
Strong Evidence
Vitamin D supplementation may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve serum 25-hydroxyvitamin d?
Strong Evidence
Vitamin D supplementation appears to improve Serum 25-hydroxyvitamin D.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 80.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve fasting insulin levels?
Strong Evidence
Vitamin D supplementation may improve Fasting insulin levels.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Fasting insulin levels
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve insulin resistance?
Strong Evidence
Vitamin D supplementation may improve Insulin resistance.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Next steps
Continue your research
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Evidence topics
Follow the topics this study contributes to.
Explore in Evidence Explorer
Open broader Evidence Explorer views for this relationship.
Related research
Read related research summaries.
Vitamin D may reduce inflammation in type 2 diabetesVitamin D supplementation may improve musculoskeletal pain in pregnant womenDietary supplements may lower diabetes risk in prediabetesHIIT and Aerobic-Resistance Training Improve Diabetes OutcomesHRS-7535 improves glycemic control in adults with type 2 diabetes
Sin anuncios. Sin rastreo.
Centrada en la evidencia, no en la publicidad.
Segura y privada
Tus datos siempre están protegidos.
Siempre al día
Se agregan nuevos estudios todos los días.