Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
High-Dose Vitamin D3 Does Not Improve Glycaemic Control in Type 2 Diabetes
Última actualización 24 de agosto de 2026
Key finding
Serum 25-hydroxyvitamin D concentrations increased significantly from baseline.
This study evaluated the impact of high-dose Vitamin D3 supplementation on insulin resistance and glycaemic parameters in adult males with type 2 diabetes, finding no significant differences in most outcomes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of high-dose Vitamin D3 supplementation on insulin resistance and glycaemic parameters in adult males with type 2 diabetes, finding no significant differences in most outcomes.
Clinical relevance
Understanding the effects of Vitamin D3 on diabetes management is crucial, as many patients seek alternative therapies. This study suggests that high-dose Vitamin D3 may not be effective in improving key metabolic parameters in type 2 diabetes, guiding clinicians in treatment decisions and patient expectations.
Keep in mind
Limited to adult males, which may affect generalizability. Short duration of 24 weeks may not capture long-term effects. No significant clinical improvements observed despite increased vitamin D levels.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Muhammed HN, Bassam AH, Noordin O, et al. The Effect of High-Dose Vitamin D3 Supplementation on Insulin Resistance and Glycaemic Parameters in Adult Males with Type 2 Diabetes: A Double-Blind, Randomised, Placebo-Controlled Clinical Trial. Journal of Pharmaceutical Policy and Practice. 2026;19(1):2680824. doi:10.1080/20523211.2026.2680824
Efectos Principales
No significant differences in insulin resistance (HOMA-IR) between groups at 24 weeks.
No significant differences in fasting plasma glucose levels at 24 weeks.
Vitamin D3 supplementation significantly increased serum 25-hydroxyvitamin D concentrations by 14.73 ng/mL (p=0.00012).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and BMI, Fasting Plasma Glucose (FPG), Fasting insulin levels, and 4 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- BMI
- Fasting Plasma Glucose (FPG)
- Fasting insulin levels
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
6
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
6
Related topics
7
Evidence pairs
2979
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 6 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Insulin Resistance
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
Supplements and Nutraceuticals
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
Fasting insulin levels
Vitamin D supplementation → Fasting insulin levels
Vitamin D supplementation → Fasting insulin levels
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 75
- consistent
Estudios de apoyo: Basado en 4 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerInsulin resistance
Vitamin D supplementation → Insulin resistance
Vitamin D supplementation → Insulin resistance
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Add to Evidence TrackerSerum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Evidence Intelligence™
- EvidenceScore™
- 80
- Strong
- ImpactScore™
- 93
- Very Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 6 estudios
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
La Evidencia Sugiere
- Vitamin D3 significantly increased serum 25-hydroxyvitamin D concentrations.
- No improvement in insulin resistance or glycaemic control was found.
- Findings suggest limited effectiveness of high-dose Vitamin D3 in diabetes management.
A quién se aplica
- Adult males aged 18-65 with type 2 diabetes.
- Individuals seeking alternative treatments for diabetes management.
Tener en Cuenta
- Results may not apply to females or other age groups.
- Further research is needed to explore long-term effects of Vitamin D3.
- The study focused on a specific population, limiting broader applicability.
Entre Líneas
- Limited to adult males, which may affect generalizability.
- Short duration of 24 weeks may not capture long-term effects.
- No significant clinical improvements observed despite increased vitamin D levels.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Insulin Resistance, Vitamin D supplementation and Insulin Resistance.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 70
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
View evidenceSupplements
Vitamin D supplementation → lipid profiles
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
Insulin Resistance Evidence Hub
All studies measuring Insulin Resistance
5 studies
outcome_hubMeasures Insulin Resistance as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
5 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
lipid profiles Evidence Hub
All studies measuring lipid profiles
1 studies
outcome_hubMeasures lipid profiles as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Vitamin D supplementation and Fasting insulin levels
Intervention: Vitamin D supplementationOutcome: Fasting insulin levels
5 results
All studies on Vitamin D supplementation and Insulin resistance
Intervention: Vitamin D supplementationOutcome: Insulin resistance
5 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
5 results
All studies measuring Fasting insulin levels
Outcome: Fasting insulin levels
5 results
All studies measuring Insulin resistance
Outcome: Insulin resistance
5 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve fasting insulin levels?
Strong Evidence
Vitamin D supplementation may improve fasting insulin levels.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Fasting insulin levels
EvidenceScore™ Strong | EvidenceScore™ 83.8 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Vitamin D supplementation improve insulin resistance?
Strong Evidence
Vitamin D supplementation may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Strong | EvidenceScore™ 83.8 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Vitamin D supplementation lower HbA1c?
Strong Evidence
Vitamin D supplementation may lower HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Vitamin D supplementation improve serum 25-hydroxyvitamin d?
Strong Evidence
Vitamin D supplementation appears to improve serum 25-hydroxyvitamin d.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 80.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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