Resumen de Investigación
Analyzed using Evidence Intelligence™

Vitamin D supplementation may improve musculoskeletal pain in pregnant women

Última actualización 6 de julio de 2026

Key finding

There was a statistically significant difference in serum vitamin D level (P=0.016)

This study investigated the impact of vitamin D supplementation on fasting blood glucose levels in pregnant women with gestational diabetes, finding no significant effect on glucose levels.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

Guarda este estudio en tu Evidence Tracker para encontrarlo facilmente cuando lo necesites.

Plain-language summary

What this paper says

A plain-language read of the study's main message and where it applies.

Study focus

This study investigated the impact of vitamin D supplementation on fasting blood glucose levels in pregnant women with gestational diabetes, finding no significant effect on glucose levels.

Clinical relevance

Understanding the effects of vitamin D supplementation in pregnant women with gestational diabetes is crucial for developing effective management strategies. Although vitamin D improved serum levels, the lack of impact on fasting blood glucose suggests that additional interventions may be necessary to manage this condition effectively.

Keep in mind

Limited sample size may affect generalizability Short duration of supplementation could limit long-term effects Potential unmeasured confounders not accounted for

Published in

Referencia de la Revista

Publication details and source links for this paper.

Zahra M, Sakineh M, Elnaz S, Shamsi A, Mojgan M. The effect of vitamin D supplementation on fasting blood glucose levels in pregnant women with gestational diabetes. BMC Endocrine Disorders. 2022;22:254. doi:10.1186/s12902-022-01159-4

Efectos Principales

No significant change in fasting blood glucose (P=0.850)

Significant increase in serum vitamin D levels (P=0.016)

Significant differences in knee pain (P=0.025) and ankle pain (P<0.001)

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Vitamin D supplementation and Ankle pain, Blood glucose, Depression score, and 7 more.

Primary intervention

Vitamin D supplementation

Primary outcomes

  • Ankle pain
  • Blood glucose
  • Depression score

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

10
Evidence pairs
10
Relationships
3
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

3

Related topics

10

Evidence pairs

489

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 10 evidence relationships
  • Includes primary outcome data
  • Linked to 3 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Agrega evidencia relacionada a tu Evidence Tracker

Guarda estudios y paginas de evidencia, organiza tu Evidence Tracker y manten en un solo lugar la investigacion que te importa.

Evidencia principal

Tema de evidencia

Insulin Resistance

matched_intervention_and_outcome

Evidencia relacionada

Tema de evidencia

Supplements and Nutraceuticals

Seguir evidencia

Core evidence

Study findings

The primary outcomes reported in this study.

Ankle pain

Vitamin D supplementation → Ankle pain

Vitamin D supplementation → Ankle pain

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Blood glucose

Vitamin D supplementation → Blood glucose

Vitamin D supplementation → Blood glucose

Evidence Intelligence™
ImpactScore™
67
Slightly Positive
EvidenceScore™
Strong
Score 79 · Based on 3 studies
ConsistencyScore™
67
generally_consistent
Supporting studies: Based on 3 studies
Add to Evidence Tracker

Depression score

Vitamin D supplementation → Depression score

Vitamin D supplementation → Depression score

Evidence Intelligence™
ImpactScore™
75
Positive
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ConsistencyScore™
35
mixed
Supporting studies: Based on 2 studies
Add to Evidence Tracker

Fasting insulin levels

Vitamin D supplementation → Fasting insulin levels

Vitamin D supplementation → Fasting insulin levels

Evidence Intelligence™
ImpactScore™
63
Slightly Positive
EvidenceScore™
Strong
Score 79 · Based on 4 studies
ConsistencyScore™
75
consistent
Supporting studies: Based on 4 studies
Add to Evidence Tracker

Frequency of abortion

Vitamin D supplementation → Frequency of abortion

Vitamin D supplementation → Frequency of abortion

Evidence Intelligence™
ImpactScore™
50
Neutral
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Gestational diabetes mellitus incidence

Vitamin D supplementation → Gestational diabetes mellitus incidence

Vitamin D supplementation → Gestational diabetes mellitus incidence

Evidence Intelligence™
ImpactScore™
50
Neutral
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Insulin resistance

Vitamin D supplementation → Insulin resistance

Vitamin D supplementation → Insulin resistance

Evidence Intelligence™
ImpactScore™
63
Slightly Positive
EvidenceScore™
Strong
Score 79 · Based on 4 studies
ConsistencyScore™
35
mixed
Supporting studies: Based on 4 studies
Add to Evidence Tracker

Knee pain

Vitamin D supplementation → Knee pain

Vitamin D supplementation → Knee pain

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Leg pain

Vitamin D supplementation → Leg pain

Vitamin D supplementation → Leg pain

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Serum concentration of vitamin D

Vitamin D supplementation → Serum concentration of vitamin D

Vitamin D supplementation → Serum concentration of vitamin D

Evidence Intelligence™
ImpactScore™
100
Very Positive
EvidenceScore™
Strong
Score 79 · Based on 4 studies
ConsistencyScore™
100
consistent
Supporting studies: Based on 4 studies
Add to Evidence Tracker

Build your personal Evidence Workspace

Create a free account to save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.

Today's Activity

Your Evidence Workspace

Free account

Saved this study

Your free account becomes your personal diabetes evidence workspace.

Evidence Tracker

12 tracked topics

Saved Studies

48 studies

Research Notes

Coming Soon

Weekly Evidence Digest

Coming Soon

evidence suggest

La Evidencia Sugiere

  • No change in fasting blood glucose levels (P=0.850)
  • Significant increase in serum vitamin D levels (P=0.016)
  • Significant reduction in knee and ankle pain
who this applies

A quién se aplica

  • Pregnant women diagnosed with gestational diabetes
  • Women in their second or third trimester of pregnancy
keep in mind

Tener en Cuenta

  • Results may not apply to populations outside the study demographics
  • The study did not assess long-term effects of vitamin D supplementation
  • Findings should be interpreted with caution due to the lack of significant changes in key metabolic outcomes
between the lines

Entre Líneas

  • Limited sample size may affect generalizability
  • Short duration of supplementation could limit long-term effects
  • Potential unmeasured confounders not accounted for

Save this study

Keep this study in your Evidence Tracker so you can easily find it again whenever you need it.

Today's Activity

Your Evidence Workspace

Free account

Saved this study

Your free account becomes your personal diabetes evidence workspace.

Evidence Tracker

12 tracked topics

Saved Studies

48 studies

Research Notes

Coming Soon

Weekly Evidence Digest

Coming Soon

Already have an account?

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Vitamin D supplementation and Insulin Resistance, Vitamin D supplementation and Insulin Resistance.

Relaciones de evidencia relacionadas

Explore in Evidence Archive

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Vitamin D supplementation improve serum concentration of vitamin d?

Strong Evidence

Vitamin D supplementation appears to improve Serum concentration of vitamin D.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Serum concentration of vitamin D

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Vitamin D supplementation improve fasting insulin levels?

Strong Evidence

Vitamin D supplementation may improve Fasting insulin levels.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

  1. 1

    Fasting insulin levels

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Vitamin D supplementation improve blood glucose?

Strong Evidence

Vitamin D supplementation may improve Blood glucose.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    Blood glucose

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Vitamin D supplementation improve insulin resistance?

Strong Evidence

Vitamin D supplementation may improve Insulin resistance.

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    Insulin resistance

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
Learn how Evidence Intelligence™ works

Next steps

Continue your research

Choose a next path through related evidence topics, archive views, and research summaries.

No ads. No tracking.

Focused on evidence, not advertising.

Secure & private

Your data is always protected.

Always up to date

New studies added every day.